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fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1

Stable Identifier
R-HSA-158795
Type
Reaction
Species
Homo sapiens
Compartment
Summation

Plasminogen activator inhibitor 1, a serpin, binds to fibrin-associated tissue plasminogen activator. The resulting stable complex remains associated with fibrin but cannot activate plasminogen (Wagner et al. 1989). The importance of this step in the regulation of clot dissolution in vivo is indicated by the occurence of thrombosis in individuals with abnormally little tissue plasminogen activator or abnormally much plasminogen activator inhibitor (Juhan-Vague et al. 1987).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase inhibitor activity of SERPINE1-like proteins [extracellular region]
Physical Entity
Activity
Orthologous Events