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SERPINE1 [extracellular region]
Stable Identifier
R-HSA-158797
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Plasminogen activator inhibitor-1, PAI1
Icon
Locations in the PathwayBrowser for interactor UniProt:P78337 PITX1
Expand all
Circadian Clock (Homo sapiens)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (Homo sapiens)
Expression of SERPINE1 (PAI-1) (Homo sapiens)
SERPINE1 [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)
SERPINE1 [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Dissolution of Fibrin Clot (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Homo sapiens)
SERPINE1 [extracellular region] (Homo sapiens)
fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Homo sapiens)
SERPINE1 [extracellular region] (Homo sapiens)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)
SERPINE1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P05121 SERPINE1
Gene Names
SERPINE1, PAI1, PLANH1
Chain
signal peptide:1-23, chain:24-402
Reference Genes
BioGPS Gene:5054 SERPINE1
COSMIC (genes):SERPINE1 SERPINE1
CTD Gene:5054 SERPINE1
dbSNP Gene:5054 SERPINE1
ENSEMBL:ENSG00000106366 SERPINE1
HGNC:8583 SERPINE1
KEGG Gene (Homo sapiens):5054 SERPINE1
Monarch:5054 SERPINE1
NCBI Gene:5054 SERPINE1
OMIM:173360 SERPINE1
UCSC:P05121 SERPINE1
Reference Transcript
RefSeq:NM_000602.4 SERPINE1
Other Identifiers
0006840139
11715636_a_at
11746856_a_at
11757312_x_at
17049676
202627_s_at
202628_s_at
3016149
3016150
3016153
3016154
3016158
3016161
3016163
3016166
3016168
3016170
3016172
38125_at
5054
672_at
8135069
A_14_P105272
A_14_P119092
A_24_P158089
GE57824
GO:0001300
GO:0001525
GO:0002020
GO:0002376
GO:0002576
GO:0003674
GO:0004867
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005886
GO:0006810
GO:0006950
GO:0007155
GO:0007165
GO:0007568
GO:0007623
GO:0008150
GO:0008219
GO:0009058
GO:0010466
GO:0010469
GO:0010757
GO:0010951
GO:0014912
GO:0016192
GO:0019899
GO:0030154
GO:0030194
GO:0030195
GO:0030198
GO:0030234
GO:0030336
GO:0030414
GO:0031012
GO:0031093
GO:0031410
GO:0032757
GO:0033629
GO:0034641
GO:0035491
GO:0040011
GO:0042730
GO:0043226
GO:0045766
GO:0045944
GO:0048260
GO:0048646
GO:0048856
GO:0048870
GO:0050729
GO:0050829
GO:0051604
GO:0051918
GO:0061044
GO:0061045
GO:0062023
GO:0070062
GO:0071222
GO:0090026
GO:0090399
GO:0097187
GO:1901331
GO:1902042
GO:2000098
GO:2000352
Hs.82085.0.S1_3p_a_at
ILMN_1744381
J03764_at
PH_hs_0024995
TC07000643.hg
TC07002499.hg
X04729_s_at
g10835158_3p_a_at
Participant Of
hasComponent
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 [extracellular region]
fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 [extracellular region]
Vitronectin:Plasminogen activator inhibitor 1 [extracellular region]
input
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1
fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
VTN binds Plasminogen activator inhibitor- 1
output
Expression of SERPINE1 (PAI-1)
hasMember
Platelet alpha granule contents [extracellular region]
SERPINE1-like proteins [extracellular region]
Other forms of this molecule
SERPINE1 [plasma membrane]
SERPINE1 [platelet alpha granule lumen]
SERPINE1 [extracellular region]
Inferred To
Spn42Da [extracellular region] (Drosophila melanogaster)
srp-6 [extracellular region] (Caenorhabditis elegans)
Serpine1 [extracellular region] (Mus musculus)
Serpine1 [extracellular region] (Rattus norvegicus)
Spn28Dc [extracellular region] (Drosophila melanogaster)
Spn28Da [extracellular region] (Drosophila melanogaster)
Spn77Bc [extracellular region] (Drosophila melanogaster)
Spn88Eb [extracellular region] (Drosophila melanogaster)
Spn27A [extracellular region] (Drosophila melanogaster)
srp-2 [extracellular region] (Caenorhabditis elegans)
Spn77Ba [extracellular region] (Drosophila melanogaster)
Acp76A [extracellular region] (Drosophila melanogaster)
Spn100A [extracellular region] (Drosophila melanogaster)
Spn42Dd [extracellular region] (Drosophila melanogaster)
srp-8 [extracellular region] (Caenorhabditis elegans)
Spn43Aa [extracellular region] (Drosophila melanogaster)
Spn47C [extracellular region] (Drosophila melanogaster)
Dmel\CG43366 [extracellular region] (Drosophila melanogaster)
srp-7 [extracellular region] (Caenorhabditis elegans)
Spn42Db [extracellular region] (Drosophila melanogaster)
Spn75F [extracellular region] (Drosophila melanogaster)
Spn28Db [extracellular region] (Drosophila melanogaster)
Homologues of SERPINE1 [extracellular region] (Caenorhabditis elegans)
Homologues of SERPINE1 [extracellular region] (Drosophila melanogaster)
Spn55B [extracellular region] (Drosophila melanogaster)
nec [extracellular region] (Drosophila melanogaster)
Spn31A [extracellular region] (Drosophila melanogaster)
Spn43Ab [extracellular region] (Drosophila melanogaster)
Spn53F [extracellular region] (Drosophila melanogaster)
Spn88Ea [extracellular region] (Drosophila melanogaster)
srp-1 [extracellular region] (Caenorhabditis elegans)
Spn38F [extracellular region] (Drosophila melanogaster)
Spn77Bb [extracellular region] (Drosophila melanogaster)
srp-3 [extracellular region] (Caenorhabditis elegans)
Spn42De [extracellular region] (Drosophila melanogaster)
serpine1 [extracellular region] (Danio rerio)
serpine1 [extracellular region] (Xenopus tropicalis)
Spn28B [extracellular region] (Drosophila melanogaster)
Spn85F [extracellular region] (Drosophila melanogaster)
SERPINE1 [extracellular region] (Bos taurus)
SERPINE1 [extracellular region] (Caenorhabditis elegans)
SERPINE1 [extracellular region] (Canis familiaris)
SERPINE1 [extracellular region] (Sus scrofa)
Spn28F [extracellular region] (Drosophila melanogaster)
Spn43Ad [extracellular region] (Drosophila melanogaster)
Cross References
RefSeq
NP_000593.1
OpenTargets
ENSG00000106366
ZINC - Substances
PAI1_HUMAN
ZINC - Biogenic
PAI1_HUMAN
ZINC target
P05121
PRO
P05121
PDB
1DB2
,
6GWP
,
3UT3
,
1C5G
,
1B3K
,
6GWQ
,
5BRR
,
1DVM
,
3R4L
,
3PB1
,
1OC0
,
6GWN
,
1A7C
,
5ZLZ
,
4G8R
,
3CVM
,
1LJ5
,
1DVN
,
3Q02
,
4AQH
,
9PAI
,
4G8O
,
3Q03
,
6I8S
,
4IC0
,
3EOX
ZINC - Investigational
PAI1_HUMAN
GeneCards
P05121
HPA
ENSG00000106366-SERPINE1
Ensembl
ENSG00000106366
,
ENST00000223095
,
ENSP00000223095
Orphanet
15273
ZINC - Predictions - Purchasable
PAI1_HUMAN
HMDB Protein
HMDBP01864
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.718
6
UniProt:Q96EQ0 SGTB
0.718
6
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q9UMX0-2 UBQLN1
0.556
3
UniProt:P78337 PITX1
0.556
3
UniProt:O43711 TLX3
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
3
UniProt:P02763 ORM1
4
ORM1 [specific granule lumen]
(R-HSA-6799632)
ORM1 [platelet alpha granule lumen]
(R-HSA-8848906)
ORM1 [extracellular region]
(R-HSA-6799687)
ORM1 [tertiary granule lumen]
(R-HSA-6801026)
0.537
4
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