Reactome: A Curated Pathway Database

fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1

Stable Identifier
R-HSA-158800
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Plasminogen activator inhibitor 1, a serpin, binds to fibrin-associated tissue plasminogen activator. The resulting stable complex remains associated with fibrin but cannot activate plasminogen (Wagner et al. 1989). The importance of this step in the regulation of clot dissolution in vivo is indicated by the occurence of thrombosis in individuals with abnormally little tissue plasminogen activator or abnormally much plasminogen activator inhibitor (Juhan-Vague et al. 1987).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase inhibitor activity of SERPINE1-like proteins [extracellular region] SERPINE1-like proteins [extracellular region] serine-type endopeptidase inhibitor activity (0004867)
Orthologous Events