Reactome: A Curated Pathway Database

alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin

Stable Identifier
R-HSA-158893
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Plasmin binds the serpin alpha-2-antiplasmin, forming a stable and catalytically inactive complex. While several serpin proteins bind and inactivate plasmin in vitro, alpha-2-antiplasmin appears to be the only one with substantial plasmin-neutralizing activity in vivo (Moroi and Aoki 1976; Lijnen et al. 1987).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase inhibitor activity of SERPINF2 [extracellular region] SERPINF2 [extracellular region] serine-type endopeptidase inhibitor activity (0004867)
Orthologous Events