urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-158942
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The small amount of plasmin generated by the activity of the one-chain form of urokinase plasminogen activator in turn cleaves urokinase plasminogen activator, converting it to its substantially more active two-chain form (Cubellis et al. 1986; Lijnen et al. 1991).

Literature References
PubMed ID Title Journal Year
2935528 Activation of plasminogen by pro-urokinase. I. Mechanism.

Lijnen, HR, Zamarron, C, Blaber, M, Winkler, ME, Collen, D

J Biol Chem 1986
3023326 Binding of single-chain prourokinase to the urokinase receptor of human U937 cells

Cubellis, MV, Nolli, ML, Cassani, G, Blasi, F

J Biol Chem 1986
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Plasmin [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored