Reactome: A Curated Pathway Database

urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-158942
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The small amount of plasmin generated by the activity of the one-chain form of urokinase plasminogen activator in turn cleaves urokinase plasminogen activator, converting it to its substantially more active two-chain form (Cubellis et al. 1986; Lijnen et al. 1991).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase activity of Plasmin [extracellular region] Plasmin [extracellular region] serine-type endopeptidase activity (0004252)
Orthologous Events