Reactome | urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR

urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR

Stable Identifier

R-HSA-158959

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR

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The uncleaved (one-chain) form of urokinase plasminogen activator associates with urokinase plasminogen activator receptor (uPAR), forming a complex at the cell surface (Cubellis et al. 1986). The complex is anchored to the outer face of the plasma membrane by a glycophosphatidylinositol moiety at the carboxy terminus of uPAR (Behrendt et al. 1990; Ploug et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
2156852	The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants. Ploug, M, Blasi, F, Nielsen, LS, Appella, E, Dano, K, Lober, D, Ronne, E, Schleuning, WD, Behrendt, N, Petri, T	J Biol Chem	1990
3023326	Binding of single-chain prourokinase to the urokinase receptor of human U937 cells Blasi, F, Nolli, ML, Cubellis, MV, Cassani, G	J Biol Chem	1986
1846368	Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. Ploug, M, Blasi, F, Dano, K, Ronne, E, Behrendt, N, Jensen, AL	J Biol Chem	1991