urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR

Stable Identifier
R-HSA-158959
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The uncleaved (one-chain) form of urokinase plasminogen activator associates with urokinase plasminogen activator receptor (uPAR), forming a complex at the cell surface (Cubellis et al. 1986). The complex is anchored to the outer face of the plasma membrane by a glycophosphatidylinositol moiety at the carboxy terminus of uPAR (Behrendt et al. 1990; Ploug et al. 1991).

Literature References
PubMed ID Title Journal Year
3023326 Binding of single-chain prourokinase to the urokinase receptor of human U937 cells

Cubellis, MV, Nolli, ML, Cassani, G, Blasi, F

J Biol Chem 1986
2156852 The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

Behrendt, N, Ronne, E, Ploug, M, Petri, T, Lober, D, Nielsen, LS, Schleuning, WD, Blasi, F, Appella, E, Dano, K

J Biol Chem 1990
1846368 Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.

Ploug, M, Ronne, E, Behrendt, N, Jensen, AL, Blasi, F, Dano, K

J Biol Chem 1991
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