Reactome: A Curated Pathway Database

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-159001
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated (two-chain) urokinase plasminogen activator binds plasminogen activator inhibitor 2, a serpin, to form a stable, inactive complex that remains associated with uPAR on the plasma membrane (Estreicher et al. 1990; Kruithof et al. 1986).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
serine-type endopeptidase inhibitor activity of plasminogen activator inhibitor [plasma membrane] plasminogen activator inhibitor [plasma membrane] serine-type endopeptidase inhibitor activity (0004867)
Orthologous Events