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urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-159001
Type
Reaction
Species
Homo sapiens
Compartment
Summation

Activated (two-chain) urokinase plasminogen activator binds plasminogen activator inhibitor 2, a serpin, to form a stable, inactive complex that remains associated with uPAR on the plasma membrane (Estreicher et al. 1990; Kruithof et al. 1986).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase inhibitor activity of plasminogen activator inhibitor [plasma membrane]
Physical Entity
Activity
Orthologous Events