urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-159005
Type
Reaction
Species
Homo sapiens
Compartment
Summation

Activated (two-chain) urokinase plasminogen activator binds plasminogen activator inhibitor 1, a serpin, to form a stable, inactive complex that remains associated with uPAR on the plasma membrane (Cubellis et al. 1989).

Literature References
PubMed ID Title Journal Year
2544876 Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor Proc Natl Acad Sci U S A 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase inhibitor activity of SERPINE1-like proteins [plasma membrane]
Physical Entity
Activity
Orthologous Events