Reactome | Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC

Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC

Stable Identifier

R-HSA-159046

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope, cytosol, nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once the transport complex is fully assembled the mature mRNA can be translocated from the nucleoplasm to the cytoplasm. The assembled complex starts at the nucleoplasmic basket, travels through the pore, and ends it journey at the cytoplasmic face of the nuclear pore complex.

Literature References

PubMed ID	Title	Journal	Year
2017161	Regulation of histone mRNA in the unperturbed cell cycle: evidence suggesting control at two posttranscriptional steps. Marzluff, WF, Schumperli, D, Schneiderman, MH, Ramamurthy, L, Harris, ME, Bohni, R	Mol Cell Biol	1991
23804756	Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins Marzluff, WF, Lerner, R, von Moeller, H, Ricciardi, A, Conti, E, Basquin, C	Nucleic Acids Res.	2013