ZBP1 binds cytosolic DNA

Stable Identifier
R-HSA-1591234
Type
Reaction
Species
Homo sapiens
Related Species
Human cytomegalovirus, Human alphaherpesvirus 2
Compartment
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ZBP1(DAI) binds to double-stranded DNA in vitro and in vivo (Wang ZC et al 2008; Takaoka A et al 2007). N-teminus of ZBP1 contains two Z-DNA (Zalpha and Zbeta) and one B-DNA binding domains (D3 region). D3 region mediates initial binding of ZBP1 to DNA with subsequent stabilization provided by the Zalpha and Zbeta domains. All tree DNA-binding domains are required for ZBP1 full activation (Wang ZC et al 2008).

ZBP1 was reported to form multimer upon DNA binding that might facilitate innate immune responces (Wang ZC et al 2008; Ha SC et al 2008).

Literature References
PubMed ID Title Journal Year
18375758 Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

Wang, Z, Choi, MK, Ban, T, Yanai, H, Negishi, H, Tamura, T, Takaoka, A, Nishikura, K, Taniguchi, T, Lu, Y

Proc Natl Acad Sci U S A 2008
21471454 Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs

Kim, K, Khayrutdinov, BI, Lee, CK, Cheong, HK, Kang, SW, Park, H, Lee, S, Kim, YG, Jee, J, Rich, A, Kim, KK, Jeon, YH

Proc Natl Acad Sci U S A 2011
17618271 DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Takaoka, A, Wang, Z, Choi, MK, Yanai, H, Negishi, H, Lu, Y, Ban, T, Miyagishi, M, Kodama, T, Honda, K, Ohba, Y, Taniguchi, T

Nature 2007
19095800 The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA

Ha, SC, Kim, D, Hwang, HY, Rich, A, Kim, YG, Kim, KK

Proc Natl Acad Sci U S A 2008
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