Reactome | UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG

UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG

Stable Identifier

R-HSA-159179

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP

ReviewStatus

5/5

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UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG

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The principal conjugate of bilirubin in bile is bilirubin diglucuronide (BDG). UGT1A4 can transfer glucuronic acid (GlcA) to bilirubin (BIL) and bilirubin monoglucuronide (BMG) to form both the monoglucuronide and the diglucuronide (BDG) conjugates respectively (Ritter et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
1339448	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini Owens, IS, Chen, F, Ritter, JK, Kimura, S, Sheen, YY, Yeatman, MT, Tran, HM	J. Biol. Chem.	1992