Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
NRF1 [nucleoplasm]
Stable Identifier
R-HSA-1592205
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear respiratory factor 1, NRF1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of ATP5B (Homo sapiens)
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of CYCS (Homo sapiens)
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of NRF1 (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of TFAM (Homo sapiens)
TFAM gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of TFB1M (Homo sapiens)
TFB1M gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of TFB2M (Homo sapiens)
TFB2M gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16656 NRF1
Gene Names
NRF1
Chain
chain:1-503
Reference Genes
BioGPS Gene:4899 NRF1
COSMIC (genes):NRF1 NRF1
CTD Gene:4899 NRF1
dbSNP Gene:4899 NRF1
ENSEMBL:ENSG00000106459 NRF1
HGNC:7996 NRF1
KEGG Gene (Homo sapiens):4899 NRF1
Monarch:4899 NRF1
NCBI Gene:4899 NRF1
OMIM:600879 NRF1
UCSC:Q16656 NRF1
Reference Transcript
RefSeq:NM_001293164.1 NRF1
RefSeq:NM_001293163.1 NRF1
RefSeq:NM_005011.4 NRF1
RefSeq:NM_001040110.1 NRF1
Other Identifiers
0006550066
11741386_a_at
11743883_s_at
11744658_s_at
11759653_at
17051480
204651_at
204652_s_at
211280_s_at
3023566
3023567
3023571
3023579
3023580
3023584
3023585
3023589
3023593
3023594
3023595
3023597
3023601
3023611
3023625
3023626
3023627
3023628
3023629
3023630
3023631
3023632
3023634
3023636
38569_at
4899
52618_at
8136140
A_14_P120952
A_14_P133123
A_23_P59418
GE62394
GE795037
GO:0000978
GO:0000979
GO:0001046
GO:0001228
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006091
GO:0006357
GO:0007005
GO:0008150
GO:0009058
GO:0034641
GO:0042803
GO:0043226
GO:0045944
GO:0070062
Hs.180069.0.S2_3p_at
ILMN_1656017
ILMN_2249551
ILMN_2326578
L22454_at
PH_hs_0027980
TC07000801.hg
TC07002582.hg
U02683_s_at
U18383_s_at
U44848_at
g347959_3p_a_at
g4826865_3p_a_at
Participant Of
input
NRF1, PPRC1, NRF2 bind the TFAM promoter
NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter
NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter
NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter
NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter
NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter
NRF1:PPARGC1B binds the ALAS1 promoter
NRF1:PPARGC1B binds the ATP5B promoter
NRF1:PPARGC1B binds the CYCS promoter
hasComponent
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm]
ATP5B gene:NRF1:PPARGC1B [nucleoplasm]
CYCS gene:NRF1:PPARGC1B [nucleoplasm]
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm]
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm]
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm]
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm]
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm]
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm]
output
Expression of NRF1
Inferred To
NRF1 [nucleoplasm] (Bos taurus)
NRF1 [nucleoplasm] (Canis familiaris)
NRF1 [nucleoplasm] (Gallus gallus)
NRF1 [nucleoplasm] (Sus scrofa)
nrf1 [nucleoplasm] (Danio rerio)
nrf1 [nucleoplasm] (Xenopus tropicalis)
ewg [nucleoplasm] (Drosophila melanogaster)
Nrf1 [nucleoplasm] (Mus musculus)
Nrf1 [nucleoplasm] (Rattus norvegicus)
Cross References
RefSeq
NP_001280093.1
,
NP_001280092.1
,
NP_001035199.1
,
NP_005002.3
OpenTargets
ENSG00000106459
GeneCards
Q16656
HPA
ENSG00000106459-NRF1
Ensembl
ENSG00000106459
,
ENST00000311967
,
ENST00000393232
,
ENST00000353868
,
ENSP00000223190
,
ENSP00000376924
,
ENST00000393230
,
ENSP00000342351
,
ENSP00000309826
,
ENSP00000376922
,
ENST00000223190
PRO
Q16656
HMDB Protein
HMDBP08663
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.556
3
UniProt:Q02446 SP4
0.556
3
UniProt:Q7Z3K3 POGZ
0.556
3
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q9NRC8 SIR7
0.524
2
UniProt:P63167 DYNLL1
6
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ciliary tip]
(R-HSA-5625335)
0.508
2
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cytosol]
(R-HSA-2029024)
0.508
2
UniProt:P24385 CCND1
4
CCND1 [cytosol]
(R-HSA-68328)
CCND1 [nucleoplasm]
(R-HSA-113832)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
0.508
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text