Reactome | NRF1 [nucleoplasm]

NRF1 [nucleoplasm]

Stable Identifier

R-HSA-1592205

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear respiratory factor 1, NRF1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Regulation of lipid metabolism by PPARalpha (Homo sapiens)
    - PPARA activates gene expression (Homo sapiens)
      - Expression of ALAS1 (Homo sapiens)
        
        ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
        
        NRF1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16656 NRF1

Gene Names

NRF1

Chain

chain:1-503

Reference Genes

BioGPS Gene:4899 NRF1

COSMIC (genes):NRF1 NRF1

CTD Gene:4899 NRF1

dbSNP Gene:4899 NRF1

ENSEMBL:ENSG00000106459 NRF1

HGNC:7996 NRF1

KEGG Gene (Homo sapiens):4899 NRF1

Monarch:4899 NRF1

NCBI Gene:4899 NRF1

OMIM:600879 NRF1

UCSC:Q16656 NRF1

Reference Transcript

Other Identifiers

0006550066

11741386_a_at

11743883_s_at

11744658_s_at

11759653_at

17051480

204651_at

204652_s_at

211280_s_at

3023566

3023567

3023571

3023579

3023580

3023584

3023585

3023589

3023593

3023594

3023595

3023597

3023601

3023611

3023625

3023626

3023627

3023628

3023629

3023630

3023631

3023632

3023634

3023636

38569_at

4899

52618_at

8136140

A_14_P120952

A_14_P133123

A_23_P59418

GE62394

GE795037

GO:0000978

GO:0000979

GO:0001046

GO:0001228

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006091

GO:0006357

GO:0007005

GO:0008150

GO:0009058

GO:0034641

GO:0042803

GO:0043226

GO:0045944

GO:0070062

Hs.180069.0.S2_3p_at

ILMN_1656017

ILMN_2249551

ILMN_2326578

L22454_at

PH_hs_0027980

TC07000801.hg

TC07002582.hg

U02683_s_at

U18383_s_at

U44848_at

g347959_3p_a_at

g4826865_3p_a_at

Participant Of

input

hasComponent

output

Expression of NRF1

Inferred To

NRF1 [nucleoplasm] (Bos taurus)

NRF1 [nucleoplasm] (Canis familiaris)

NRF1 [nucleoplasm] (Gallus gallus)

NRF1 [nucleoplasm] (Sus scrofa)

nrf1 [nucleoplasm] (Danio rerio)

nrf1 [nucleoplasm] (Xenopus tropicalis)

ewg [nucleoplasm] (Drosophila melanogaster)

Nrf1 [nucleoplasm] (Mus musculus)

Nrf1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001280093.1, NP_001280092.1, NP_005002.3, NP_001035199.1

OpenTargets

ENSG00000106459

GeneCards

Q16656

HPA

ENSG00000106459-NRF1

Ensembl

ENST00000223190, ENST00000393230, ENSP00000376924, ENSP00000376922, ENSP00000309826, ENSG00000106459, ENST00000311967, ENST00000353868, ENST00000393232, ENSP00000223190, ENSP00000342351

PRO

Q16656

HMDB Protein

HMDBP08663

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	3
UniProt:Q02446 SP4			0.556	3
UniProt:Q7Z3K3 POGZ			0.556	3
UniProt:Q9NRC8 SIR7			0.524	2
UniProt:P63167 DYNLL1	6	DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.508	2
UniProt:P24385 CCND1	4	CCND1 [cytosol] (R-HSA-68328) CCND1 [nucleoplasm] (R-HSA-113832) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.508	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cytosol] (R-HSA-2029024)	0.508	2

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