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NRF1 [nucleoplasm]
Stable Identifier
R-HSA-1592205
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear respiratory factor 1, NRF1_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Mitochondrial unfolded protein response (UPRmt) (Homo sapiens)
p-S167-ESR1 activates expression of NRF1 (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of ATP5B (Homo sapiens)
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of CYCS (Homo sapiens)
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of NRF1 (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of TFAM (Homo sapiens)
TFAM gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of TFB1M (Homo sapiens)
TFB1M gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
Expression of TFB2M (Homo sapiens)
TFB2M gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16656 NRF1
Gene Names
NRF1
Chain
chain:1-503
Reference Genes
COSMIC (genes):NRF1 NRF1
dbSNP Gene:4899 NRF1
ENSEMBL:ENSG00000106459 NRF1
Participates
as an input of
NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)
NRF1:PPARGC1B binds the CYCS promoter (Homo sapiens)
NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)
NRF1:PPARGC1B binds the ALAS1 promoter (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)
NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)
as a component of
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
CYCS gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
ATP5B gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
ALAS1 gene:NRF1:PPARGC1B [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
as an output of
Expression of NRF1 (Homo sapiens)
p-S167-ESR1 activates expression of NRF1 (Homo sapiens)
Inferred To
NRF1 [nucleoplasm]
(Bos taurus)
NRF1 [nucleoplasm]
(Canis familiaris)
NRF1 [nucleoplasm]
(Gallus gallus)
NRF1 [nucleoplasm]
(Sus scrofa)
nrf1 [nucleoplasm]
(Danio rerio)
nrf1 [nucleoplasm]
(Xenopus tropicalis)
ewg [nucleoplasm]
(Drosophila melanogaster)
Nrf1 [nucleoplasm]
(Mus musculus)
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.666
5
UniProt:Q02446 SP4
0.556
3
UniProt:Q7Z3K3 POGZ
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:Q6PJI9 WDR59
1
WDR59 [lysosomal membrane]
(R-HSA-9638236)
0.527
3
UniProt:Q9NRC8 SIR7
0.524
2
UniProt:P63167 DYNLL1
6
DYNLL1 [cytosol]
(R-HSA-387105)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ciliary tip]
(R-HSA-5625335)
0.508
2
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
0.508
2
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.508
2
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