Reactome | SP1 [nucleoplasm]

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 targets host intracellular signalling and regulatory pathways (Homo sapiens)
        
        SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)
        
        SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300:SERPINE1 gene [nucleoplasm] (Homo sapiens)
        
        SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300 [nucleoplasm] (Homo sapiens)
        
        SP1 [nucleoplasm] (Homo sapiens)
        
        SP1 [nucleoplasm] (Homo sapiens)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14859 POU2F1	1	POU2F1 [nucleoplasm] (R-HSA-83836)	0.725	7
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.681	4
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.649	4
UniProt:Q12772 SREBF2	5	SREBF2(1-1141) [Golgi membrane] (R-HSA-1655747) SREBF2(1-522) [Golgi membrane] (R-HSA-1655752) SREBF2(1-484) [cytosol] (R-HSA-1655723) SREBF2(1-1141) [endoplasmic reticulum membrane] (R-HSA-1655733) SREBF2(1-484) [nucleoplasm] (R-HSA-1655745)	0.635	3
IntAct:EBI-10685841 TF65			0.602	3
UniProt:Q92988 DLX4			0.602	4
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.59	3
UniProt:O92837 O92837			0.589	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.589	6
UniProt:Q9UL17 TBX21			0.576	4
UniProt:Q8N680 ZBTB2			0.576	4
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.573	2
UniProt:P04198 MYCN	1	MYCN [nucleoplasm] (R-HSA-452357)	0.564	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.564	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.558	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.544	2
UniProt:Q06546 GABPA	1	GABPA [nucleoplasm] (R-HSA-1592206)	0.544	2
UniProt:P03070 LT			0.544	2
UniProt:P17096 HMGA1	2	HMGA1 [cytosol] (R-HSA-3004619) HMGA1 [nucleoplasm] (R-HSA-3004623)	0.544	4
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.544	4
IntAct:EBI-10048213 CREM			0.527	2
IntAct:EBI-10684794 TF65			0.525	3
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.524	3
UniProt:Q06455 MTG8			0.524	2
UniProt:Q13118 KLF10			0.508	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.508	2
UniProt:Q7Z3K3 POGZ			0.508	2
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.508	2
UniProt:P32519 ELF1	1	ELF1 [nucleoplasm] (R-HSA-8938902)	0.508	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.508	2
IntAct:EBI-2694074 MDM2			0.499	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.499	4
UniProt:P23708 Nfya	2	Nfya [nucleoplasm] (R-MMU-2426381) Nfya [nucleoplasm] (R-MMU-420841)	0.488	18
UniProt:P06401 PGR	3	monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032) PGR [cytosol] (R-HSA-8948964) PGR [nucleoplasm] (R-HSA-3008952)	0.462	2