TFAM translocates from the cytosol to the mitochondrial matrix

Stable Identifier
R-HSA-1592229
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

TFAM is encoded in the nucleus, synthesized as a precursor in the cytosol, and imported into the mitochondrial matrix (presumably by the SAM50 complex and the TIM23:PAM complex, reviewed in van der Laan et al. 2006). In the mitochondrial matrix TFAM binds the light strand promoter of mitochondrial DNA and regulates transcription.

Literature References
PubMed ID Title Journal Year
16911507 Mitochondrial preprotein translocases as dynamic molecular machines FEMS Yeast Res. 2006
Participants
Participant Of
Inferred From