TFAM translocates from the cytosol to the mitochondrial matrix

Stable Identifier
R-HSA-1592229
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TFAM is encoded in the nucleus, synthesized as a precursor in the cytosol, and imported into the mitochondrial matrix (presumably by the SAM50 complex and the TIM23:PAM complex, reviewed in van der Laan et al. 2006). In the mitochondrial matrix TFAM binds the light strand promoter of mitochondrial DNA and regulates transcription.

Literature References
PubMed ID Title Journal Year
16911507 Mitochondrial preprotein translocases as dynamic molecular machines

van der Laan, M, Rissler, M, Rehling, P

FEMS Yeast Res. 2006
Participants
Participant Of
Inferred From
Authored
Reviewed
Created