Expression of POLRMT

Stable Identifier
R-HSA-1592243
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Summation

The POLRMT (mitochondrial RNA polymerase) gene is transcribed in the nucleus to yield mRNA and the mRNA is translated in the cytosol to yield POLRMT precursor, which is then imported into the mitochondria matrix. In the mitochondrial matrix POLRMT transcribes mitochondrial DNA.

Literature References
PubMed ID Title Journal Year
16079853 Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin

Kravchenko, JE, Rogozin, IB, Koonin, EV, Chumakov, PM

Nature 2005
19951946 Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication

Bruni, F, Polosa, PL, Gadaleta, MN, Cantatore, P, Roberti, M

J Biol Chem 2010
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