Expression of POLRMT

Stable Identifier
R-HSA-1592243
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The POLRMT (mitochondrial RNA polymerase) gene is transcribed in the nucleus to yield mRNA and the mRNA is translated in the cytosol to yield POLRMT precursor, which is then imported into the mitochondria matrix. In the mitochondrial matrix POLRMT transcribes mitochondrial DNA.
Literature References
PubMed ID Title Journal Year
19951946 Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication

Cantatore, P, Gadaleta, MN, Roberti, M, Polosa, PL, Bruni, F

J Biol Chem 2010
16079853 Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin

Koonin, EV, Kravchenko, JE, Chumakov, PM, Rogozin, IB

Nature 2005
Participants
Participates
This event is regulated
Positively by
Authored
Reviewed
Created
Cite Us!