Reactome | Full activation of MMP1

Full activation of MMP1

Stable Identifier

R-HSA-1592297

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The 42 kDa intermediate form of MMP1 is fully activated by cleavage of the Gln99-Phe100 bond, producing a 41 kDa protein. MMP2 (Crabbe et al. 1994), MMP3 (Suzuki et al. 1990, Nagase et al. 1992), MMP7 (Imai et al. 1995), MMP10 (Nicholson et al. 1989) and MMP11 (Murphy et al. 1993) are able to convert the 42 kDa intermediate to fully activated 41 kDa form though they are not able to initiate activation of proMMP1 effectively (Nagase et al. 1992). MMP3 regulates MMP1 collagenase activity in human rheumatoid synovial fibroblasts (Unemori et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
2169257	The role of matrix metalloproteinase 3 in the stepwise activation of human rheumatoid synovial procollagenase Salvesen, G, Nagase, H, Ito, A, Suzuki, K, Enghild, JJ	Biol Chem Hoppe Seyler	1990
1480033	Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3 Morodomi, T, Salvesen, G, Nagase, H, Suzuki, K, Enghild, JJ	Matrix Suppl	1992
7981201	Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase A Smith, BJ, O'Connell, JP, Docherty, AJ, Crabbe, T	Biochemistry	1994