Reactome | UPF3B [cytosol]

UPF3B [cytosol]

Stable Identifier

R-HSA-159258

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

hUpf3B, UPf3B

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        UPF3 [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        UPF3B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BZI7 UPF3B

Gene Names

UPF3B, RENT3B, UPF3X

Chain

chain:1-483

Reference Genes

BioGPS Gene:65109 UPF3B

COSMIC (genes):UPF3B UPF3B

CTD Gene:65109 UPF3B

dbSNP Gene:65109 UPF3B

ENSEMBL:ENSG00000125351 UPF3B

HGNC:20439 UPF3B

KEGG:hsa:65109 UPF3B

Monarch:65109 UPF3B

NCBI Gene:65109 UPF3B

OMIM:300298 UPF3B

UCSC:Q9BZI7 UPF3B

Reference Transcript

Participates

as a member of

UPF3 [cytosol] (Homo sapiens)

as a component of

EJC [cytosol] (Homo sapiens)

Other forms of this molecule

UPF3B [nucleoplasm]

Inferred To

UPF3B [cytosol] (Bos taurus)

UPF3B [cytosol] (Dictyostelium discoideum)

UPF3B [cytosol] (Gallus gallus)

UPF3B [cytosol] (Sus scrofa)

Upf3b [cytosol] (Mus musculus)

Upf3b [cytosol] (Rattus norvegicus)

upf3 [cytosol] (Schizosaccharomyces pombe)

upf3b [cytosol] (Danio rerio)

UPF3 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of UPF3B [cytosol] (Canis familiaris)

Ghost homologue of UPF3B [cytosol] (Xenopus tropicalis)

Upf3 [cytosol] (Drosophila melanogaster)

smg-4 [cytosol] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000276201, ENSG00000125351, ENSP00000276201, ENSP00000245418, ENST00000345865

OpenTargets

ENSG00000125351

GeneCards

UPF3B

HPA

ENSG00000125351-UPF3B

PRO

Q9BZI7

Pharos - Targets

Q9BZI7

GlyGen

Q9BZI7

Orphanet

UPF3B

PDB

1UW4, 7NWU, 2XB2

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5S9 RBM8A	2	RBM8A [nucleoplasm] (R-HSA-156659) RBM8A [cytosol] (R-HSA-162462)	0.914	10
UniProt:Q9HAU5 UPF2	1	UPF2 [cytosol] (R-HSA-927799)	0.897	9
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.886	11
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.883	9
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.773	7
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.643	3
UniProt:O15234 CASC3	2	CASC3 [nucleoplasm] (R-HSA-8849148) CASC3 [cytosol] (R-HSA-927807)	0.643	3
UniProt:Q92900-2 UPF1			0.527	2
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.527	2