benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate

Stable Identifier
R-HSA-159443
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Benzoate and Coenzyme A react to form benzoyl-CoA thioester
Locations in the PathwayBrowser
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Benzoate and ATP react with coenzyme A to form benzoyl CoA, AMP, and pyrophosphate (Vessey et al. 1999, 2003). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to benzoate metabolism in vivo are unknown.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created