salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate

Stable Identifier
R-HSA-159567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Salicylic acid and Coenzyme A react to form salicylate-CoA thioester
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Salicylate and ATP react with coenzyme A to form salicylate CoA, AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003).

Literature References
PubMed ID Title Journal Year
5862532 Pharmacokinetics of salicylate elimination in man

Levy, G

J Pharm Sci 1965
12616642 Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria

Vessey, DA, Lau, E, Kelley, M, Warren, RS

J Biochem Mol Toxicol 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
CoA-ligase activity of ACSM2B-like proteins [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created