Reactome | ACSM2B-like proteins transform ST to ST-CoA

ACSM2B-like proteins transform ST to ST-CoA

Stable Identifier

R-HSA-159567

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

salicylate + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate, Salicylic acid and Coenzyme A react to form salicylate-CoA thioester

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase II - Conjugation of compounds (Homo sapiens)
    - Amino Acid conjugation (Homo sapiens)
      - Conjugation of carboxylic acids (Homo sapiens)
        
        Conjugation of salicylate with glycine (Homo sapiens)
        
        ACSM2B-like proteins transform ST to ST-CoA (Homo sapiens)

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ACSM2B-like proteins transform ST to ST-CoA

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Salicylate (ST) and ATP react with coenzyme A to form salicylate-CoA (ST-CoA), AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12616642	Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria Kelley, M, Warren, RS, Lau, E, Vessey, DA	J Biochem Mol Toxicol	2003
5862532	Pharmacokinetics of salicylate elimination in man Levy, G	J Pharm Sci	1965