GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)

Stable Identifier
R-HSA-159752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
pro-protein S, uncarboxylated + 11 CO2 + 11 O2 + 11 vitamin K hydroquinone -> pro-protein S + 11 H2O + 11 vitamin K epoxide
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates eleven glutamate residues on PROS1(25-676) (pro-protein S). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).
Literature References
PubMed ID Title Journal Year
10068650 Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid

Furie, B, Bouchard, BA, Furie, BC

Blood 1999
10917896 The vitamin K-dependent carboxylase

Berkner, KL

J Nutr 2000
8530480 Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate.

Stafford, DW, Wright, DJ, Stevens, RD, Morris, DP

J Biol Chem 1995
11513608 Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo

Stenina, O, Pudota, BN, Berkner, KL, McNally, BA, Hommema, EL

Biochemistry 2001
Participants
Participates
Catalyst Activity

gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]

Orthologous Events
Created
Cite Us!