Activation of MT-MMPs by FURIN

Stable Identifier
R-HSA-1602466
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen
ReviewStatus
5/5
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Activation of MT-MMPs by FURIN
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The membrane-type MMPs (MT-MMPs) MMP14 (MT1-MMP) (Pei et al. 1996, Sato et al. 1996) and MMP16 (MT3-MMP) (Kang et al. 2002) are processed to an active form by furin (Yana & Weiss 2000) and PACE4 (Bassi et al. 2005) within the golgi before secretion. The other MT-MMPs MMP15 (MT2-MMP), MMP17 (MT4-MMP) (Itoh et al. 1999), MMP24 (MT5-MMP) and MMP25 (MT6-MMP) (Starr et al. 2012) are believed to undergo similar processing before membrane association.
Literature References
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Output
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Catalyst Activity

serine-type endopeptidase activity of FURIN [Golgi membrane]

Physical Entity
FURIN [Golgi membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Activation of MT-MMPs by FURIN (Bos taurus)
Activation of MT-MMPs by FURIN (Caenorhabditis elegans)
Activation of MT-MMPs by FURIN (Canis familiaris)
Activation of MT-MMPs by FURIN (Danio rerio)
Activation of MT-MMPs by FURIN (Drosophila melanogaster)
Activation of MT-MMPs by FURIN (Gallus gallus)
Activation of MT-MMPs by FURIN (Mus musculus)
Activation of MT-MMPs by FURIN (Rattus norvegicus)
Activation of MT-MMPs by FURIN (Sus scrofa)
Activation of MT-MMPs by FURIN (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-14)
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