Reactome | MMP2(67-660) [extracellular region]

MMP2(67-660) [extracellular region]

Stable Identifier

R-HSA-1604345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MMP2 intermediate form, Matrix metalloproteinase-2, MMP2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08253 MMP2

Gene Names

MMP2, CLG4A

Chain

signal peptide:1-29, propeptide:30-109, chain:110-660, chain:445-660

Reference Genes

BioGPS Gene:4313 MMP2

COSMIC (genes):MMP2 MMP2

CTD Gene:4313 MMP2

dbSNP Gene:4313 MMP2

ENSEMBL:ENSG00000087245 MMP2

HGNC:7166 MMP2

KEGG Gene (Homo sapiens):4313 MMP2

Monarch:4313 MMP2

NCBI Gene:4313 MMP2

OMIM:120360 MMP2

UCSC:P08253 MMP2

Reference Transcript

Other Identifiers

0006940402

11741377_a_at

11743250_a_at

11743251_s_at

11745767_a_at

16819062

16819064

201069_at

3661685

3661686

3661687

3661688

3661691

3661692

3661694

3661695

3661697

3661699

3661701

3661702

3661703

3661704

3661705

3661707

3661708

3661709

3661710

3661711

3661712

3661713

39007_at

4313

56572_at

7995681

A_14_P114963

A_21_P0009102

A_23_P163787

A_33_P3237135

GE79835

GE88806

GO:0000003

GO:0001525

GO:0001666

GO:0001955

GO:0001957

GO:0003674

GO:0004175

GO:0004222

GO:0004252

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005886

GO:0006508

GO:0006950

GO:0007165

GO:0007566

GO:0008150

GO:0008233

GO:0008237

GO:0008270

GO:0008283

GO:0009056

GO:0009790

GO:0016020

GO:0016787

GO:0019221

GO:0021700

GO:0022617

GO:0030017

GO:0030154

GO:0030198

GO:0030574

GO:0031012

GO:0034614

GO:0035987

GO:0043167

GO:0043226

GO:0044267

GO:0046872

GO:0048013

GO:0048646

GO:0048661

GO:0048705

GO:0048771

GO:0048856

GO:0060325

GO:0060346

GO:0062023

GO:0071230

GO:0071492

GO:1904645

GO:1904707

Hs2.367877.1.S1_3p_s_at

ILMN_1762106

M55593_at

PH_hs_0024052

TC16000454.hg

TC16001568.hg

TC16001569.hg

g11342665_3p_at

g11342665_3p_s_at

Participant Of

output

Initial activation of proMMP2 by MMP1, 7

input

Autocatalytic activation of proMMP2

hasComponent

MMP14:TIMP2:MMP2 intermediate form [plasma membrane]

Other forms of this molecule

MMP2(30-66) [extracellular region]

MMP2(30-660) [extracellular region]

MMP2(67-109) [extracellular region]

MMP2(110-660) [extracellular region]

Inferred To

mmp2 [extracellular region] (Danio rerio)

mmp2 [extracellular region] (Xenopus tropicalis)

Mmp2 [extracellular region] (Mus musculus)

Mmp2 [extracellular region] (Rattus norvegicus)

MMP2 [extracellular region] (Canis familiaris)

MMP2 [extracellular region] (Gallus gallus)

MMP2 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001289437.1, NP_001289438.1, NP_001121363.1, NP_001289439.1, NP_004521.1

ZINC - World Drugs

MMP2_HUMAN

OpenTargets

ENSG00000087245

ZINC - FDA approved

MMP2_HUMAN

ZINC - Substances

MMP2_HUMAN

ZINC - Biogenic

MMP2_HUMAN

ZINC target

P08253

PRO

P08253

PDB

1CXW, 1QIB, 3AYU, 1KS0, 1J7M, 1EAK, 1CK7, 1HOV, 1RTG, 1GXD, 1GEN

ZINC - Investigational

MMP2_HUMAN

Target Pathogen

5b354852be737e166372ec19

ZINC - Metabolites

MMP2_HUMAN

HPA

ENSG00000087245-MMP2

GeneCards

P08253

Ensembl

ENSP00000444143, ENSP00000394237, ENSG00000087245, ENST00000219070, ENST00000570308, ENSP00000461421, ENST00000543485, ENSP00000219070, ENST00000437642

ZINC - Predictions - Purchasable

MMP2_HUMAN

Orphanet

16453

HMDB Protein

HMDBP02804

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20908 COL5A1	72	3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) 3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268662) GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268625) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268688) 3x4Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268658) GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268878) 3x4Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268750) 3x4Hyp-3Hyp-GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268920) GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268923) 3x4Hyp-5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268827) 3x4Hyp-COL5A1(?-1838) [extracellular region] (R-HSA-2268810) 3x4Hyp-3Hyp-COL5A1(?-1838) [extracellular region] (R-HSA-2268730) 3x4Hyp-3Hyp-5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268789) 5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268902) 3x4Hyp-GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268806) COL5A1(?-1838) [extracellular region] (R-HSA-2268801) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268736) Collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470075) COL5A1(?-?) [extracellular region] (R-HSA-2470043) 3,4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470136) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470169) 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470174) 4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470078) Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470044) 3,4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470204) 3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470172) 3x4Hyp-COL5A1(?-?) [extracellular region] (R-HSA-2470236) 3x4Hyp-5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470108) GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470205) 4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470065) 5-hydroxylysyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470230) 3x4Hyp-GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470036) 5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470123) GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470088) 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470153) 3x4Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470190) 3x4Hyp-3Hyp-5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470095) Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127312) 4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127314) 4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127346) 3,4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127396) 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127412) 3,4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127365) 4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127429) 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127397) 4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127350) Collagen alpha-1(V) chain [extracellular region] (R-HSA-375058) 5-hydroxylysyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127433) 3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127371) 3x4Hyp-3Hyp-GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470116) 4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470112) 4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470144) 3x4Hyp-3Hyp-COL5A1(?-?) [extracellular region] (R-HSA-2470050)	0.632	3
UniProt:P05067-PRO_0000000092 APP			0.623	4
IntAct:EBI-2325312 COLLAGEN			0.618	3
UniProt:Q8NBP7 PCSK9	5	PCSK9 [lysosomal membrane] (R-HSA-8855128) PCSK9 [endolysosome membrane] (R-HSA-6784823) PCSK9 [extracellular region] (R-HSA-6784727) p-PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956943) PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956745)	0.618	4
UniProt:P16035 TIMP2	4	TIMP2 [specific granule lumen] (R-HSA-6799625) TIMP2 [ficolin-1-rich granule lumen] (R-HSA-6800944) TIMP2 [extracellular region] (R-HSA-1454879) TIMP2 [tertiary granule lumen] (R-HSA-6800881)	0.59	2
UniProt:Q04864-2 REL			0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q14508 WFDC2			0.499	12

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