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MMP2(67-660) [extracellular region]
Stable Identifier
R-HSA-1604345
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
MMP2 intermediate form, Matrix metalloproteinase-2, MMP2_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Autocatalytic activation of bound proMMP2 (Homo sapiens)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Homo sapiens)
MMP2(67-660) [extracellular region] (Homo sapiens)
MMP2(67-660) [extracellular region] (Homo sapiens)
Autocatalytic activation of proMMP2 (Homo sapiens)
MMP2(67-660) [extracellular region] (Homo sapiens)
Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)
MMP2(67-660) [extracellular region] (Homo sapiens)
Initial activation of proMMP2 by MMP14 (Homo sapiens)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Homo sapiens)
MMP2(67-660) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08253 MMP2
Gene Names
MMP2, CLG4A
Chain
signal peptide:1-29, propeptide:30-109, chain:110-660, chain:445-660
Reference Genes
BioGPS Gene:4313 MMP2
COSMIC (genes):MMP2 MMP2
CTD Gene:4313 MMP2
dbSNP Gene:4313 MMP2
ENSEMBL:ENSG00000087245 MMP2
HGNC:7166 MMP2
KEGG Gene (Homo sapiens):4313 MMP2
Monarch:4313 MMP2
NCBI Gene:4313 MMP2
OMIM:120360 MMP2
UCSC:P08253 MMP2
Reference Transcript
RefSeq:NM_001302508.1 MMP2
RefSeq:NM_001127891.2 MMP2
RefSeq:NM_001302509.1 MMP2
RefSeq:NM_001302510.1 MMP2
RefSeq:NM_004530.5 MMP2
Other Identifiers
0006940402
11741377_a_at
11743250_a_at
11743251_s_at
11745767_a_at
16819062
16819064
201069_at
3661685
3661686
3661687
3661688
3661691
3661692
3661694
3661695
3661697
3661699
3661701
3661702
3661703
3661704
3661705
3661707
3661708
3661709
3661710
3661711
3661712
3661713
39007_at
4313
56572_at
7995681
A_14_P114963
A_21_P0009102
A_23_P163787
A_33_P3237135
GE79835
GE88806
GO:0000003
GO:0001525
GO:0001666
GO:0001955
GO:0001957
GO:0003674
GO:0004175
GO:0004222
GO:0004252
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005886
GO:0006508
GO:0006950
GO:0007165
GO:0007566
GO:0008150
GO:0008233
GO:0008237
GO:0008270
GO:0008283
GO:0009056
GO:0009790
GO:0016020
GO:0016787
GO:0019221
GO:0021700
GO:0022617
GO:0030017
GO:0030154
GO:0030198
GO:0030574
GO:0031012
GO:0034614
GO:0035987
GO:0043167
GO:0043226
GO:0044267
GO:0046872
GO:0048013
GO:0048646
GO:0048661
GO:0048705
GO:0048771
GO:0048856
GO:0060325
GO:0060346
GO:0062023
GO:0071230
GO:0071492
GO:1904645
GO:1904707
Hs2.367877.1.S1_3p_s_at
ILMN_1762106
M55593_at
PH_hs_0024052
TC16000454.hg
TC16001568.hg
TC16001569.hg
g11342665_3p_at
g11342665_3p_s_at
Participant Of
output
Initial activation of proMMP2 by MMP1, 7
input
Autocatalytic activation of proMMP2
hasComponent
MMP14:TIMP2:MMP2 intermediate form [plasma membrane]
Other forms of this molecule
MMP2(30-66) [extracellular region]
MMP2(30-660) [extracellular region]
MMP2(67-109) [extracellular region]
MMP2(110-660) [extracellular region]
Inferred To
mmp2 [extracellular region] (Danio rerio)
mmp2 [extracellular region] (Xenopus tropicalis)
Mmp2 [extracellular region] (Mus musculus)
Mmp2 [extracellular region] (Rattus norvegicus)
MMP2 [extracellular region] (Canis familiaris)
MMP2 [extracellular region] (Gallus gallus)
MMP2 [extracellular region] (Sus scrofa)
Cross References
RefSeq
NP_001289437.1
,
NP_001289438.1
,
NP_001121363.1
,
NP_001289439.1
,
NP_004521.1
ZINC - World Drugs
MMP2_HUMAN
OpenTargets
ENSG00000087245
ZINC - FDA approved
MMP2_HUMAN
ZINC - Substances
MMP2_HUMAN
ZINC - Biogenic
MMP2_HUMAN
ZINC target
P08253
PRO
P08253
PDB
1CXW
,
1QIB
,
3AYU
,
1KS0
,
1J7M
,
1EAK
,
1CK7
,
1HOV
,
1RTG
,
1GXD
,
1GEN
ZINC - Investigational
MMP2_HUMAN
Target Pathogen
5b354852be737e166372ec19
ZINC - Metabolites
MMP2_HUMAN
HPA
ENSG00000087245-MMP2
GeneCards
P08253
Ensembl
ENSP00000444143
,
ENSP00000394237
,
ENSG00000087245
,
ENST00000219070
,
ENST00000570308
,
ENSP00000461421
,
ENST00000543485
,
ENSP00000219070
,
ENST00000437642
ZINC - Predictions - Purchasable
MMP2_HUMAN
Orphanet
16453
HMDB Protein
HMDBP02804
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20908 COL5A1
72
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023664)
3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023553)
GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023513)
GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023628)
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023564)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023647)
COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022460)
3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022510)
3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022483)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022948)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022970)
5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022989)
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268653)
COL5A1(38-1838) [extracellular region]
(R-HSA-2268703)
3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268718)
3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268664)
3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region]
(R-HSA-2268667)
GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268629)
5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268644)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268663)
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268662)
GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268625)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268688)
3x4Hyp-COL5A1(38-1838) [extracellular region]
(R-HSA-2268658)
GalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268878)
3x4Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268750)
3x4Hyp-3Hyp-GalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268920)
GlcGalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268923)
3x4Hyp-5Hyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268827)
3x4Hyp-COL5A1(?-1838) [extracellular region]
(R-HSA-2268810)
3x4Hyp-3Hyp-COL5A1(?-1838) [extracellular region]
(R-HSA-2268730)
3x4Hyp-3Hyp-5Hyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268789)
5Hyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268902)
3x4Hyp-GalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268806)
COL5A1(?-1838) [extracellular region]
(R-HSA-2268801)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268736)
Collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470075)
COL5A1(?-?) [extracellular region]
(R-HSA-2470043)
3,4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470136)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470169)
5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470174)
4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470078)
Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470044)
3,4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470204)
3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470172)
3x4Hyp-COL5A1(?-?) [extracellular region]
(R-HSA-2470236)
3x4Hyp-5Hyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470108)
GalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470205)
4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470065)
5-hydroxylysyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470230)
3x4Hyp-GalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470036)
5Hyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470123)
GlcGalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470088)
3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470153)
3x4Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470190)
3x4Hyp-3Hyp-5Hyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470095)
Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127312)
4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127314)
4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127346)
3,4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127396)
3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127412)
3,4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127365)
4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127429)
5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127397)
4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127350)
Collagen alpha-1(V) chain [extracellular region]
(R-HSA-375058)
5-hydroxylysyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127433)
3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127371)
3x4Hyp-3Hyp-GalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470116)
4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470112)
4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470144)
3x4Hyp-3Hyp-COL5A1(?-?) [extracellular region]
(R-HSA-2470050)
0.632
3
UniProt:P05067-PRO_0000000092 APP
0.623
4
IntAct:EBI-2325312 COLLAGEN
0.618
3
UniProt:Q8NBP7 PCSK9
5
PCSK9 [lysosomal membrane]
(R-HSA-8855128)
PCSK9 [endolysosome membrane]
(R-HSA-6784823)
PCSK9 [extracellular region]
(R-HSA-6784727)
p-PCSK9 [endoplasmic reticulum lumen]
(R-HSA-8956943)
PCSK9 [endoplasmic reticulum lumen]
(R-HSA-8956745)
0.618
4
UniProt:P16035 TIMP2
4
TIMP2 [specific granule lumen]
(R-HSA-6799625)
TIMP2 [ficolin-1-rich granule lumen]
(R-HSA-6800944)
TIMP2 [extracellular region]
(R-HSA-1454879)
TIMP2 [tertiary granule lumen]
(R-HSA-6800881)
0.59
2
UniProt:Q04864-2 REL
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q14508 WFDC2
0.499
12
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