Reactome | MMP2(67-660) [extracellular region]

MMP2(67-660) [extracellular region]

Stable Identifier

R-HSA-1604345

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MMP2 intermediate form, Matrix metalloproteinase-2, MMP2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08253 MMP2

Gene Names

MMP2, CLG4A

Chain

signal peptide:1-29, propeptide:30-109, chain:110-660, chain:445-660

Reference Genes

BioGPS Gene:4313 MMP2

COSMIC (genes):MMP2 MMP2

CTD Gene:4313 MMP2

dbSNP Gene:4313 MMP2

ENSEMBL:ENSG00000087245 MMP2

HGNC:7166 MMP2

KEGG Gene (Homo sapiens):4313 MMP2

Monarch:4313 MMP2

NCBI Gene:4313 MMP2

OMIM:120360 MMP2

UCSC:P08253 MMP2

Reference Transcript

Other Identifiers

0006940402

11741377_a_at

11743250_a_at

11743251_s_at

11745767_a_at

16819062

16819064

1939

1CK7

1CXW

1EAK

1GEN

1GXD

1HOV

1J7M

1KS0

1QIB

1RTG

201069_at

2788

3661685

3661686

3661687

3661688

3661691

3661692

3661694

3661695

3661697

3661699

3661701

3661702

3661703

3661704

3661705

3661707

3661708

3661709

3661710

3661711

3661712

3661713

39007_at

3AYU

4313

56572_at

7995681

A0A024R6R4

A_14_P114963

A_21_P0009102

A_23_P163787

A_33_P3237135

AAA35701

AAA52027

AAA52028

AAH02576

AAU10089

AC007336

AC092722

AK301536

AK310314

AK312711

AY738117

BAG35588

BAG63035

BC002576

CAB002788

CCDS10752

CCDS45487

CCDS76869

CH471092

EAW82824

EAW82827

EAW82828

ENSG00000087245

ENSP00000219070

ENSP00000394237

ENSP00000444143

ENSP00000461421

ENST00000219070

ENST00000219070.8

ENST00000437642

ENST00000437642.6

ENST00000543485

ENST00000543485.5

ENST00000570308

ENST00000570308.5

EntrezGene:4313

EntrezGene:MMP2

g11342665_3p_at

g11342665_3p_s_at

GE79835

GE88806

GO:0000003

GO:0001525

GO:0001666

GO:0001955

GO:0001957

GO:0003674

GO:0004222

GO:0004252

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005886

GO:0006508

GO:0006950

GO:0007165

GO:0007566

GO:0008150

GO:0008233

GO:0008237

GO:0008270

GO:0008283

GO:0009056

GO:0009790

GO:0016020

GO:0016787

GO:0019221

GO:0021700

GO:0022617

GO:0030017

GO:0030154

GO:0030198

GO:0030574

GO:0031012

GO:0034614

GO:0035987

GO:0043167

GO:0043226

GO:0044267

GO:0046872

GO:0048013

GO:0048646

GO:0048661

GO:0048705

GO:0048771

GO:0048856

GO:0060325

GO:0060346

GO:0062023

GO:0071230

GO:1904645

GO:1904707

H3BR66

H3BS34

H3BV48

HGNC:7166

HPA001939

Hs2.367877.1.S1_3p_s_at

ILMN_1762106

IPR000562

IPR000585

IPR001818

IPR002477

IPR006026

IPR013806

IPR018486

IPR018487

IPR021158

IPR021190

IPR024079

IPR028708

IPR033739

IPR036365

IPR036366

IPR036375

IPR036943

J03210

M33789

M55582

M55583

M55584

M55585

M55586

M55587

M55588

M55589

M55590

M55591

M55592

M55593

M55593_at

M58552

MIM:120360

MIM:259600

MMP2

MMP2-201

MMP2-202

MMP2-203

MMP2-208

NM_001127891

NM_001302508

NM_001302509

NM_001302510

NM_004530

NP_001121363

NP_001289437

NP_001289438

NP_001289439

NP_004521

PF00040

PF00045

PF00413

PF01471

PH_hs_0024052

PR00013

PR00138

SM00059

SM00120

SM00235

TC16000454.hg

TC16001568.hg

TC16001569.hg

UPI00000422C4

UPI000153CBE2

UPI0001756A92

Participant Of

output

Initial activation of proMMP2 by MMP1, 7

input

Autocatalytic activation of proMMP2

hasComponent

MMP14:TIMP2:MMP2 intermediate form [plasma membrane]

Other forms of this molecule

MMP2(30-66) [extracellular region]

MMP2(30-660) [extracellular region]

MMP2(67-109) [extracellular region]

MMP2(110-660) [extracellular region]

Inferred To

Homologues of MMP2(67-660) [extracellular region] (Caenorhabditis elegans)

MMP2(67-660) [extracellular region] (Bos taurus)

MMP2(67-660) [extracellular region] (Caenorhabditis elegans)

MMP2(67-660) [extracellular region] (Canis familiaris)

MMP2(67-660) [extracellular region] (Danio rerio)

MMP2(67-660) [extracellular region] (Gallus gallus)

MMP2(67-660) [extracellular region] (Mus musculus)

MMP2(67-660) [extracellular region] (Rattus norvegicus)

MMP2(67-660) [extracellular region] (Sus scrofa)

MMP2(67-660) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_004521.1, NP_001289438.1, NP_001121363.1, NP_001289439.1, NP_001289437.1

ZINC - World Drugs

MMP2_HUMAN

OpenTargets

ENSG00000087245

ZINC - FDA approved

MMP2_HUMAN

ZINC - Substances

MMP2_HUMAN

ZINC - Biogenic

MMP2_HUMAN

ZINC target

P08253

PRO

P08253

PDB

1KS0, 1CXW, 1GEN, 1GXD, 1HOV, 1J7M, 3AYU, 1QIB, 1CK7, 1RTG, 1EAK

ZINC - Investigational

MMP2_HUMAN

ZINC - Metabolites

MMP2_HUMAN

GeneCards

P08253

Orphanet

16453

ZINC - Predictions - Purchasable

MMP2_HUMAN

HMDB Protein

HMDBP02804

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20908 COL5A1	72	3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) 3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268662) GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268625) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268688) 3x4Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268658) GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268878) 3x4Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268750) 3x4Hyp-3Hyp-GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268920) GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268923) 3x4Hyp-5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268827) 3x4Hyp-COL5A1(?-1838) [extracellular region] (R-HSA-2268810) 3x4Hyp-3Hyp-COL5A1(?-1838) [extracellular region] (R-HSA-2268730) 3x4Hyp-3Hyp-5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268789) 5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268902) 3x4Hyp-GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268806) COL5A1(?-1838) [extracellular region] (R-HSA-2268801) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268736) Collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470075) COL5A1(?-?) [extracellular region] (R-HSA-2470043) 3,4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470136) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470169) 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470174) 4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470078) Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470044) 3,4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470204) 3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470172) 3x4Hyp-COL5A1(?-?) [extracellular region] (R-HSA-2470236) 3x4Hyp-5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470108) GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470205) 4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470065) Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127312) 4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127314) 4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127346) 3,4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127396) 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127412) 3,4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127365) 4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127429) 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127397) 4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127350) Collagen alpha-1(V) chain [extracellular region] (R-HSA-375058) 5-hydroxylysyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127433) 3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127371) 3x4Hyp-3Hyp-GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470116) 4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470112) 4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470144) 3x4Hyp-3Hyp-COL5A1(?-?) [extracellular region] (R-HSA-2470050) 3x4Hyp-3Hyp-5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470095) 3x4Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470190) 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470153) GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470088) 5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470123) 3x4Hyp-GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470036) 5-hydroxylysyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470230)	0.632	3
UniProt:P05067-PRO_0000000092 APP			0.623	4
IntAct:EBI-2325312 COLLAGEN			0.618	3
UniProt:Q8NBP7 PCSK9	5	PCSK9 [lysosomal membrane] (R-HSA-8855128) PCSK9 [endolysosome membrane] (R-HSA-6784823) PCSK9 [extracellular region] (R-HSA-6784727) p-PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956943) PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956745)	0.618	4
UniProt:P16035 TIMP2	4	TIMP2 [specific granule lumen] (R-HSA-6799625) TIMP2 [tertiary granule lumen] (R-HSA-6800881) TIMP2 [extracellular region] (R-HSA-1454879) TIMP2 [ficolin-1-rich granule lumen] (R-HSA-6800944)	0.59	2
UniProt:Q04864-2 REL			0.488	2