Initial activation of proMMP2 by MMP1, 7

Stable Identifier
R-HSA-1604359
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Initial activation of proMMP2 by MMP1, 7
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MMP2 can be activated by MMP1 (Crabbe et al. 1994a, Sang et al. 1996) and MMP7 (Crabbe et al. 1994b, Sang et al. 1996). MMP1 initially cleaves either Pro33-Ile34 or Asn66-Leu67. This is followed by autolytic cleavage at Asn109-Tyr110 (Crabbe et al. 1994a, Okada et al. 1990, Sang et al. 1996). MMP1 and MMP7 are not efficient activators of MMP2; significant physiological activation of proMMP2 is performed by the MT-MMPs MMP14 (Sato et al. 1994), MMP15 (Butler et al. 1997, Morrison et al. 2001) and MMP16 (Takino et al. 1995). Residue numbering here refers to the UniProt canonical sequence.
Literature References
PubMed ID Title Journal Year
8194591 Human progelatinase A can be activated by matrilysin

Crabbe, T, Smith, B, O'Connell, J, Docherty, A

FEBS Lett 1994
8015608 A matrix metalloproteinase expressed on the surface of invasive tumour cells

Sato, H, Takino, T, Okada, Y, Cao, J, Shinagawa, A, Yamamoto, E, Seiki, M

Nature 1994
7981201 Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase A

Crabbe, T, O'Connell, JP, Smith, BJ, Docherty, AJ

Biochemistry 1994
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Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of MMP1,7 [extracellular region]

Physical Entity
MMP1,7 [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Initial activation of proMMP2 by MMP1, 7 (Bos taurus)
Initial activation of proMMP2 by MMP1, 7 (Caenorhabditis elegans)
Initial activation of proMMP2 by MMP1, 7 (Canis familiaris)
Initial activation of proMMP2 by MMP1, 7 (Danio rerio)
Initial activation of proMMP2 by MMP1, 7 (Drosophila melanogaster)
Initial activation of proMMP2 by MMP1, 7 (Gallus gallus)
Initial activation of proMMP2 by MMP1, 7 (Mus musculus)
Initial activation of proMMP2 by MMP1, 7 (Rattus norvegicus)
Initial activation of proMMP2 by MMP1, 7 (Sus scrofa)
Initial activation of proMMP2 by MMP1, 7 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-15)
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