Reactome | DTX2 [cytosol]

DTX2 [cytosol]

Stable Identifier

R-HSA-1604436

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein deltex-2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q86UW9 DTX2

Gene Names

DTX2, KIAA1528, RNF58

Chain

chain:1-622

Reference Genes

BioGPS Gene:113878 DTX2

COSMIC (genes):DTX2 DTX2

CTD Gene:113878 DTX2

dbSNP Gene:113878 DTX2

ENSEMBL:ENSG00000091073 DTX2

ENSEMBL_homo_sapiens_GENE:ENSG00000091073 DTX2

HGNC:15973 DTX2

KEGG Gene (Homo sapiens):113878 DTX2

Monarch:113878 DTX2

NCBI Gene:113878 DTX2

OMIM:613141 DTX2

UCSC:Q86UW9 DTX2

Reference Transcript

Other Identifiers

0003190168

113878

11740981_a_at

11755938_a_at

17124592

17124594

17124596

215732_3p_s_at

215732_s_at

3009474

3009477

3009478

3009481

3009488

3009489

3009490

3009491

3009492

3009502

3009503

3009504

3009507

3009512

3009514

3009516

3009517

3009518

3009519

3009724

3009725

3009730

3009731

3009733

3009734

3009735

3009736

3009738

3009741

3009744

3009745

3009747

3009752

37977_at

42931

8133736

A0A0J9YXJ6

A_21_P0013244

A_23_P395033

A_33_P3502640

AAH08856

AAH18555

AAH26059

AAH93079

AAP21881

AAP57518

AAP57519

AAY27263

AB040961

AC005522

AC007078

AK023924

AY225124

AY225125

BAA96052

BAB14727

BC008856

BC018555

BC026059

BC093079

C9JEH4

C9JF39

C9JII1

C9JLU8

C9JS11

C9JVC8

C9JY61

CCDS43605

CCDS5587

DQ010329

DTX2

DTX2-201

DTX2-202

DTX2-206

DTX2-212

E7ET89

ENSG00000091073

ENSP00000322885

ENSP00000390218

ENSP00000392545

ENSP00000411986

ENST00000324432

ENST00000324432.9

ENST00000413936

ENST00000413936.6

ENST00000430490

ENST00000430490.6

ENST00000446820

ENST00000446820.6

EntrezGene:113878

GE85812

GO:0003674

GO:0005515

GO:0005575

GO:0005634

GO:0005654

GO:0005737

GO:0006464

GO:0007165

GO:0007219

GO:0008270

GO:0016567

GO:0016740

GO:0031965

GO:0043167

GO:0043226

GO:0046872

HGNC:15973

HPA042931

Hs.89135.2.S1_3p_a_at

Hs.89135.2.S1_3p_x_at

ILMN_1659104

ILMN_1744129

ILMN_2275098

IPR001841

IPR004170

IPR013083

IPR018123

IPR018957

IPR037197

IPR039396

IPR039398

IPR039399

MIM:613141

NM_001102594

NM_001102595

NM_001102596

NM_020892

NP_001096064

NP_001096065

NP_001096066

NP_065943

PF00097

PF02825

PF18102

PH_hs_0027181

Q75MM6

SM00184

SM00678

TC07003309.hg

UPI00001413A2

UPI00003674C1

XM_005250131

XM_005250132

XM_011515772

XM_011515773

XM_011515774

XM_011515775

XM_017011723

XM_017011724

XM_017011725

XM_017011726

XM_017011727

XM_024446649

XM_024446650

XM_024446651

XP_005250188

XP_005250189

XP_011514074

XP_011514075

XP_011514076

XP_011514077

XP_016867212

XP_016867213

XP_016867214

XP_016867215

XP_016867216

XP_024302417

XP_024302418

XP_024302419

Participant Of

hasCandidate

DTX [cytosol]

Inferred To

Homologues of DTX2 [cytosol] (Danio rerio)

DTX2 [cytosol] (Bos taurus)

DTX2 [cytosol] (Danio rerio)

DTX2 [cytosol] (Drosophila melanogaster)

DTX2 [cytosol] (Gallus gallus)

DTX2 [cytosol] (Mus musculus)

DTX2 [cytosol] (Rattus norvegicus)

DTX2 [cytosol] (Sus scrofa)

DTX2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001096064.1, XP_016867215.1, XP_016867214.1, XP_011514075.1, XP_005250189.1, XP_005250188.1, XP_011514074.1, NP_001096066.1, XP_016867213.1, XP_016867212.1, XP_016867216.1, NP_001096065.1, XP_011514077.1, NP_065943.2, XP_011514076.1

OpenTargets

ENSG00000091073

IntEnz

2.3.2.27

GeneCards

Q86UW9

PRO

Q86UW9

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.696	5
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	6
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P63165 SUMO1	155	TOPORS-G97-SUMO1 [nucleoplasm] (R-HSA-4551623) K14-UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-4085334) PIAS4-G97-SUMO1 [nucleoplasm] (R-HSA-3968375) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551627) K2723-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551737) K2650-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551591) K196-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551630) K171-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551632) K159-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551713) MDM-G97-SUMO1 [nucleoplasm] (R-HSA-3730829) K575-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090305) K804-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782561) K750-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090298) K676-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090396) K554-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782555) K779-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782585) ING2-G97-SUMO1 [nucleoplasm] (R-HSA-4086096) K788-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085297) K731-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085312) K239-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085320) K239-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085299) K731-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085290) K788-NCOA2-G97-SUMO1 [nucleoplasm] (R-HSA-4085308) NPM1-G97-SUMO1 [nucleoplasm] (R-HSA-4086019) NCOR2-G97-SUMO1 [nucleoplasm] (R-HSA-3927883) DDX17-G97-SUMO1 [nucleoplasm] (R-HSA-3900210) PARK7-G97-SUMO1 [nucleoplasm] (R-HSA-4085344) K1033-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927910) K1056-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927954) K998-CREBBP-G97-SUMO1 [nucleoplasm] (R-HSA-3927822) K1154-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086067) K756-NRIP1-G97-SUMO1 [nucleoplasm] (R-HSA-4086034) DDX5-G97-SUMO1 [nucleoplasm] (R-HSA-3900212) CASP8AP2-G97-SUMO1 [nucleoplasm] (R-HSA-3927863) K1024-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899298) K1020-EP300-G97-SUMO1 [nucleoplasm] (R-HSA-3899290) CTBP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730764) K231-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085364) K294-SAFB-G97-SUMO1 [nucleoplasm] (R-HSA-4085341) K624-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900128) K576-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900225) K499-MKL1-G97-SUMO1 [nucleoplasm] (R-HSA-3900219) K631-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086044) K630-DAXX-G97-SUMO1 [nucleoplasm] (R-HSA-4086012) SIN3A-G97-SUMO1 [nucleoplasm] (R-HSA-4086058) PPARGC1A-G97-SUMO1 [nucleoplasm] (R-HSA-3903014) HIPK2-G97-SUMO1 [nucleoplasm] (R-HSA-4090362) K774-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085292) K732-NCOA1-G97-SUMO1 [nucleoplasm] (R-HSA-4085278) K538-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090416) K499-MBD1-G97-SUMO1 [nucleoplasm] (R-HSA-4090332) ZNF131-G97-SUMO1 [nucleoplasm] (R-HSA-3730875) K90-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755511) K689-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755446) K863-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755412) K298-NFKB2-G97-SUMO1 [cytosol] (R-HSA-4755505) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) p-S172-IKBKE-G97-SUMO1 [nucleoplasm] (R-HSA-4755408) K309-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755404) K277-IKBKG-G97-SUMO1 [nucleoplasm] (R-HSA-4755531) NFKBIA-G97-SUMO1 [nucleoplasm] (R-HSA-4656987) RANGAP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730796) AURKA-G97-SUMO1 [cytosol] (R-HSA-4655413) TOP2B-G97-SUMO1 [nucleoplasm] (R-HSA-4641311) TOP1-G97-SUMO1 [nucleoplasm] (R-HSA-4641306) TOP2A-G97-SUMO1 [nucleoplasm] (R-HSA-4641341) K254-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615853) K-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615836) K164-PCNA-G97-SUMO1 [nucleoplasm] (R-HSA-4615951) MDC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570527) STAG2-G97-SUMO1 [nucleoplasm] (R-HSA-3826645) RAD21-G97-SUMO1 [nucleoplasm] (R-HSA-3826574) K411-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568857) K412-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568850) K414-RAD52-G97-SUMO1 [nucleoplasm] (R-HSA-4568900) XRCC4-G97-SUMO1 [nucleoplasm] (R-HSA-4568869) K160-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730884) K490-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730833) K65-PML-G97-SUMO1 [nucleoplasm] (R-HSA-3730879) K203-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551625) K486-PARP1-G97-SUMO1 [nucleoplasm] (R-HSA-4551748) K496-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568906) K898-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568893) K356-WRN-G97-SUMO1 [nucleoplasm] (R-HSA-4568845) RNF168-SUMO1 [nucleoplasm] (R-HSA-4551631) XPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570452) TDG-G97-SUMO1 [nucleoplasm] (R-HSA-4551682) SP100-G97-SUMO1 [nucleoplasm] (R-HSA-3730794) BRCA1-G97-SUMO1 [nucleoplasm] (R-HSA-3730735) RXRA-G97-SUMO1 [nucleoplasm] (R-HSA-4341090) NR5A2-G97-SUMO1 [nucleoplasm] (R-HSA-4755424) K386-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090321) K520-AR-G97-SUMO1 [nucleoplasm] (R-HSA-4090352) K293-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341110) K277-NR3C1-G97-SUMO1 [nucleoplasm] (R-HSA-4341057) K389-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719415) K283-THRA-G97-SUMO1 [nucleoplasm] (R-HSA-4719434) K399-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341020) K428-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341035) K494-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341093) K89-NR3C2-G97-SUMO1 [nucleoplasm] (R-HSA-4341058) K119-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546379) K194-NR5A1-G97-SUMO1 [nucleoplasm] (R-HSA-4546380) NR2C1-G97-SUMO1 [nucleoplasm] (R-HSA-4717492) K303-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090373) K266-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090359) K302-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090363) K299-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090349) K268-ESR1-G97-SUMO1 [nucleoplasm] (R-HSA-4090414) K531-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341021) K7-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341052) K388-PGR-G97-SUMO1 [nucleoplasm] (R-HSA-4341056) K132-NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-9610527) NR1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4755434) PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717445) K395-PPARG-G97-SUMO1 [nucleoplasm] (R-HSA-4717446) PPARA-G97-SUMO1 [nucleoplasm] (R-HSA-4341069) K443-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719431) K146-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719410) K50-THRB-G97-SUMO1 [nucleoplasm] (R-HSA-4719401) RORA-G97-SUMO1 [nucleoplasm] (R-HSA-4719426) HIC1-G97-SUMO1 [nucleoplasm] (R-HSA-4570544) TP53BP1-G97-SUMO1 [nucleoplasm] (R-HSA-3730731) SP3-G97-SUMO1 [nucleoplasm] (R-HSA-3730646) K423-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730755) K289-MITF-G97-SUMO1 [nucleoplasm] (R-HSA-3730738) K25-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968400) K150-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968382) K114-FOXL2-G97-SUMO1 [nucleoplasm] (R-HSA-3968396) HNRNPC-G97-SUMO1 [nucleoplasm] (R-HSA-4570515) K497-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570504) K467-NOP58-G97-SUMO1 [nucleoplasm] (R-HSA-4570462) DNMT3B-G97-SUMO1 [nucleoplasm] (R-HSA-4655444) DNMT3A-G97-SUMO1 [nucleoplasm] (R-HSA-4655383) DNMT1-G97-SUMO1 [nucleoplasm] (R-HSA-4655358) K84-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615838) K-CBX5-G97-SUMO1 [nucleoplasm] (R-HSA-4615955) K476-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4615867) K444-HDAC1-G97-SUMO1 [nucleoplasm] (R-HSA-4616028) CBX4-G97-SUMO1 [nucleoplasm] (R-HSA-4551756) HDAC2-G97-SUMO1 [nucleoplasm] (R-HSA-4616032) SUZ12-G97-SUMO1 [nucleoplasm] (R-HSA-4615961) SATB1-G97-SUMO1 [nucleoplasm] (R-HSA-4615877) HDAC4-G97-SUMO1 [nucleoplasm] (R-HSA-4615956) K1971-CHD3-G97-SUMO1 [nucleoplasm] (R-HSA-8956370) HIST1H4-G97-SUMO1 [nucleoplasm] (R-HSA-4570549) BMI1-G97-SUMO1 [nucleoplasm] (R-HSA-4551654) TFAP2B-G97-SUMO1 [nucleoplasm] (R-HSA-3730839) TFAP2C-G97-SUMO1 [nucleoplasm] (R-HSA-3730823) TFAP2A-1-G97-SUMO1 [nucleoplasm] (R-HSA-3730825) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) HERC2-SUMO1 [nucleoplasm] (R-HSA-4551761)	0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.488	2
UniProt:O14964 HGS	1	HGS [cytosol] (R-HSA-182954)	0.488	2
UniProt:O43521 BCL2L11	7	BCL2L11-BRAF fusion [cytosol] (R-HSA-6802276) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) p-BCL2L11-BRAF fusion [cytosol] (R-HSA-6802519) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) p-S65-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11 [cytosol] (R-HSA-2976673)	0.488	2
UniProt:Q15436 SEC23A	4	SEC23A [cytosol] (R-HSA-203972) p-S742,T747 SEC23A [cytosol] (R-HSA-5685740) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024)	0.488	2
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.488	4
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.488	2
UniProt:P14652 HOXB2	1	HOXB2 [nucleoplasm] (R-HSA-5617487)	0.488	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [mitochondrial inner membrane] (R-HSA-5689047) ECSIT [cytosol] (R-HSA-168064)	0.488	2