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PIP4K2A [cytosol]
Stable Identifier
R-HSA-1604641
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PIP5K2, PIP5K2A
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2A [cytosol] (Homo sapiens)
PIP4K2A [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2A [cytosol] (Homo sapiens)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PIP4K2 dimers [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2A [cytosol] (Homo sapiens)
PIP4K2A [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2A [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2C [cytosol] (Homo sapiens)
PIP4K2A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Homo sapiens)
PIP4K2 dimers [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2A [cytosol] (Homo sapiens)
PIP4K2A [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2A [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2C [cytosol] (Homo sapiens)
PIP4K2A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48426 PIP4K2A
Gene Names
PIP4K2A, PI5P4KA, PIP5K2, PIP5K2A
Chain
initiator methionine:, chain:2-406
Reference Genes
BioGPS Gene:5305 PIP4K2A
COSMIC (genes):PIP4K2A PIP4K2A
CTD Gene:5305 PIP4K2A
dbSNP Gene:5305 PIP4K2A
ENSEMBL:ENSG00000150867 PIP4K2A
HGNC:8997 PIP4K2A
KEGG:hsa:5305 PIP4K2A
Monarch:5305 PIP4K2A
NCBI Gene:5305 PIP4K2A
OMIM:603140 PIP4K2A
UCSC:P48426 PIP4K2A
Reference Transcript
RefSeq:NM_001330062.1 PIP4K2A
RefSeq:XM_017016331.1 PIP4K2A
RefSeq:XM_017016330.1 PIP4K2A
RefSeq:NM_005028.4 PIP4K2A
Other Identifiers
11739347_a_at
11739348_at
11746493_a_at
11746494_x_at
16712482
205570_PM_at
205570_at
212829_PM_at
212829_at
3281069
3281070
3281071
3281072
3281076
3281077
3281079
3281080
3281092
3281103
3281104
3281108
3281116
3281117
3281125
3281126
3281127
3281128
3281130
3281131
3281146
3281148
3281150
3281168
3281169
3281170
35310_at
37412_at
5305
7932530
A_23_P104346
A_33_P3394065
GE58353
GO:0001750
GO:0001917
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005764
GO:0005773
GO:0005776
GO:0005829
GO:0005886
GO:0006629
GO:0010506
GO:0016192
GO:0016301
GO:0016308
GO:0016309
GO:0016740
GO:0035855
GO:0042803
GO:0042995
GO:0043226
GO:0046488
GO:0046627
GO:0046854
GO:0048856
GO:0052742
GO:0061024
GO:0061909
GO:0090119
GO:1902635
GO:2000786
HMNXSV003026803
HMNXSV003030182
Hs.57079.1.S1_3p_at
ILMN_1911042
PH_hs_0003680
PH_hs_0006024
S78798_s_at
TC10001101.hg
g6857819_3p_at
Participates
as a component of
PIP4K2A:PIP4K2B [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2C [cytosol] (Homo sapiens)
PIP4K2A:PIP4K2A [cytosol] (Homo sapiens)
Other forms of this molecule
PIP4K2A [nucleoplasm]
Inferred To
pip4k2aa [cytosol]
(Danio rerio)
ppk-2 [cytosol]
(Caenorhabditis elegans)
PIPkinA [cytosol]
(Dictyostelium discoideum)
PIP4K [cytosol]
(Drosophila melanogaster)
Homologues of PIP4K2A [cytosol]
(Dictyostelium discoideum)
PIP4K2A [cytosol]
(Bos taurus)
PIP4K2A [cytosol]
(Canis familiaris)
PIP4K2A [cytosol]
(Dictyostelium discoideum)
PIP4K2A [cytosol]
(Gallus gallus)
PIP4K2A [cytosol]
(Plasmodium falciparum)
PIP4K2A [cytosol]
(Sus scrofa)
Pip4k2a [cytosol]
(Mus musculus)
Pip4k2a [cytosol]
(Rattus norvegicus)
MSS4 [cytosol]
(Saccharomyces cerevisiae)
its3 [cytosol]
(Schizosaccharomyces pombe)
pip4k2a [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016871819.1
,
NP_005019.2
,
NP_001316991.1
,
XP_016871820.1
Guide to Pharmacology - Targets
2858
OpenTargets
ENSG00000150867
ENSEMBL
ENSP00000365757
,
ENSP00000442098
,
ENST00000376573
,
ENST00000545335
HPA
ENSG00000150867-PIP4K2A
PRO
P48426
Pharos - Targets
P48426
Orphanet
PIP4K2A
GlyGen
P48426
HMDB Protein
HMDBP01202
PDB
7N7J
,
6YM5
,
7N71
,
6YM4
,
7N7K
,
6YM3
,
6UX9
,
2YBX
,
7N7N
,
7N7L
,
7N6Z
,
7N7O
,
6OSP
,
8C8C
,
7N7M
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60563 CCNT1
1
CCNT1 [nucleoplasm]
(R-HSA-51611)
0.643
3
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.643
4
UniProt:O60885 BRD4
1
BRD4 [nucleoplasm]
(R-HSA-9680425)
0.527
2
UniProt:Q9UKV3 ACIN1
4
ACIN1 [cytosol]
(R-HSA-212519)
ACIN1(1094-1341) [cytosol]
(R-HSA-212516)
ACIN1(1-1093) [cytosol]
(R-HSA-212520)
ACIN1 [nucleoplasm]
(R-HSA-9770238)
0.527
2
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.527
3
UniProt:Q9UPS6 SETD1B
1
SETD1B [nucleoplasm]
(R-HSA-5244714)
0.527
2
UniProt:Q9UQ35 SRRM2
1
SRRM2 [nucleoplasm]
(R-HSA-8865888)
0.527
2
UniProt:Q13427 PPIG
2
PPIG [nucleoplasm]
(R-HSA-9769592)
PPIG [cytosol]
(R-HSA-9728768)
0.527
2
UniProt:Q03111 MLLT1
1
MLLT1 [nucleoplasm]
(R-HSA-8932918)
0.527
2
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.527
2
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.527
2
UniProt:P55199 ELL
1
ELL [nucleoplasm]
(R-HSA-54257)
0.527
2
UniProt:Q96CJ1 EAF2
1
EAF2 [nucleoplasm]
(R-HSA-8932790)
0.527
2
UniProt:Q9HCG8 CWC22
1
CWC22 [nucleoplasm]
(R-HSA-8865956)
0.527
2
UniProt:Q14678 KANK1
3
KANK1 [nucleoplasm]
(R-HSA-9018640)
p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane]
(R-HSA-9673890)
KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane]
(R-HSA-9673593)
0.527
2
UniProt:P15907 ST6GAL1
1
ST6GAL1 [Golgi membrane]
(R-HSA-975899)
0.527
2
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.527
2
UniProt:P42568 MLLT3
1
MLLT3 [nucleoplasm]
(R-HSA-8932789)
0.527
2
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