Initial activation of proMMP13 by MMP3

Stable Identifier
R-HSA-1604752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MMP3 initially cleaves proMMP13 at Gly76-Leu77 followed by autoprocessing at Glu103-Tyr104 (Knauper et al. 1996).
Literature References
PubMed ID Title Journal Year
8576151 Biochemical characterization of human collagenase-3

Smith, B, López-Otin, C, Knight, G, Knäuper, V, Murphy, G

J Biol Chem 1996
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]

Orthologous Events
Authored
Reviewed
Created
Cite Us!