Reactome | SIRT3(?-399) [mitochondrial matrix]

SIRT3(?-399) [mitochondrial matrix]

Stable Identifier

R-HSA-1605416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

SIRT3, NAD-dependent deacetylase sirtuin-3, mitochondrial, SIRT3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O60313

Expand all

Literature References

PubMed ID	Title	Journal	Year
12186850	The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase Schwer, B, North, BJ, Frye, RA, Ott, M, Verdin, E	J Cell Biol	2002

External Reference Information

External Reference

UniProt:Q9NTG7 SIRT3

Gene Names

SIRT3, SIR2L3

Chain

transit peptide:1-, chain:-399

Reference Genes

BioGPS Gene:23410 SIRT3

COSMIC (genes):SIRT3 SIRT3

CTD Gene:23410 SIRT3

dbSNP Gene:23410 SIRT3

ENSEMBL:ENSG00000142082 SIRT3

HGNC:14931 SIRT3

KEGG Gene (Homo sapiens):23410 SIRT3

Monarch:23410 SIRT3

NCBI Gene:23410 SIRT3

OMIM:604481 SIRT3

UCSC:Q9NTG7 SIRT3

Reference Transcript

Other Identifiers

0000540053

11722446_a_at

11722447_a_at

11739810_x_at

11739811_a_at

221562_s_at

221913_at

23410

3357786

3357789

3357790

3357796

3357798

3357801

3357804

3357805

3357810

3357811

3357812

3357813

3357815

49325_at

49327_at

7945357

A_23_P139265

A_24_P85158

A_24_P923684

GE58473

GO:0003674

GO:0003677

GO:0003950

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0006091

GO:0006464

GO:0006471

GO:0006476

GO:0006629

GO:0006810

GO:0006950

GO:0007005

GO:0007165

GO:0007267

GO:0007568

GO:0008150

GO:0008270

GO:0009058

GO:0009060

GO:0015031

GO:0016575

GO:0016740

GO:0016757

GO:0016810

GO:0017136

GO:0019899

GO:0032024

GO:0032991

GO:0034641

GO:0034979

GO:0034983

GO:0043167

GO:0043226

GO:0043565

GO:0046872

GO:0051276

GO:0070373

GO:0070403

GO:1901671

GO:1902553

GO:2000304

GO:2000378

HMNXSV003049799

Hs.19306.1.S1_3p_s_at

ILMN_1724372

ILMN_1733985

PH_hs_0026684

TC11001228.hg

g13259626_3p_a_at

g13259626_3p_x_at

Participates

as a component of

SIRT3(?-399):Zn2+ [mitochondrial matrix] (Homo sapiens)

as an output of

Expression of SIRT3 (Homo sapiens)

Other forms of this molecule

SIRT3 [nucleoplasm]

Inferred To

SIRT3 [mitochondrial matrix] (Bos taurus)

SIRT3 [mitochondrial matrix] (Canis familiaris)

SIRT3 [mitochondrial matrix] (Gallus gallus)

SIRT3 [mitochondrial matrix] (Sus scrofa)

Sirt3 [mitochondrial matrix] (Mus musculus)

Sirt3 [mitochondrial matrix] (Rattus norvegicus)

sirt3.1 [mitochondrial matrix] (Xenopus tropicalis)

Sirt2 [mitochondrial matrix] (Drosophila melanogaster)

sirt3 [mitochondrial matrix] (Danio rerio)

sir2B [mitochondrial matrix] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001017524.1, XP_016872919.1, NP_036371.1

ZINC - World Drugs

SIR3_HUMAN

OpenTargets

ENSG00000142082

ZINC - FDA approved

SIR3_HUMAN

ZINC - Substances

SIR3_HUMAN

ZINC target

Q9NTG7

ZINC - Biogenic

SIR3_HUMAN

PRO

Q9NTG7

PDB

5Y4H, 4JSR, 3GLR, 4C7B, 4BVH, 4FZ3, 4BVG, 6ISO, 5H4D, 5YTK, 4BVF, 4C78, 5BWO, 4BVE, 4BVB, 5BWN, 5ZGC, 5Z94, 4BN5, 3GLU, 5Z93, 4O8Z, 4JT9, 4FVT, 4HD8, 4JT8, 5D7N, 3GLS, 4BN4, 3GLT, 4BV3

ZINC - Metabolites

SIR3_HUMAN

HPA

ENSG00000142082-SIRT3

GeneCards

Q9NTG7

Ensembl

ENST00000529382, ENST00000382743, ENSP00000372191, ENSP00000437216, ENSG00000142082

ZINC - Predictions - Purchasable

SIR3_HUMAN

HMDB Protein

HMDBP08881

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963)	0.65	3
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073)	0.576	5
UniProt:P28799-2 GRN			0.556	3
UniProt:O60313 OPA1	3	OPA1(88-194) [mitochondrial inner membrane] (R-HSA-8867509) OPA1 [mitochondrial inner membrane] (R-HSA-8867508) OPA1(195-960) [mitochondrial inner membrane] (R-HSA-8867513)	0.544	3
UniProt:P25705 ATP5F1A	3	ATP5A1(1-553) [cytosol] (R-HSA-1267955) ATP5A1(1-553) [mitochondrial intermembrane space] (R-HSA-1267978) ATP5A1 [mitochondrial matrix] (R-HSA-164575)	0.524	2