Expression of SIRT3

Stable Identifier
R-HSA-1605535
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, mitochondrial matrix
ReviewStatus
5/5
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Expression of SIRT3
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As inferred from mouse, PGC-1alpha (PPARGC1A) activates expression of SIRT3 (Kong et al. 2010). The SIRT3 gene is transcribed to yield mRNA and the mRNA is translated in the cytosol to yield precursor protein. SIRT3 is imported into the mitochondrial matrix where it deacetylates, and hence activates, target proteins
Literature References
PubMed ID Title Journal Year
18215119 The human SIRT3 protein deacetylase is exclusively mitochondrial

Cooper, HM, Spelbrink, JN

Biochem J 2008
16079181 Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

Michishita, E, Park, JY, Burneskis, JM, Barrett, JC, Horikawa, I

Mol Biol Cell 2005
17437997 SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress

Scher, MB, Vaquero, A, Reinberg, D

Genes Dev 2007
12374852 SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

Onyango, P, Celic, I, McCaffery, JM, Boeke, JD, Feinberg, AP

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
p-PPARGC1A [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-09-10)
Reviewed
Lezza, AM  (2013-12-07)
Created
May, B  (2011-09-21)
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