Reactome | PSAP(311-391) [lysosomal membrane]

PSAP(311-391) [lysosomal membrane]

Stable Identifier

R-HSA-1605602

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

SAPC, Saposin-C, SAP-2, Proactivator polypeptide component recommendedName: Saposin-A, PSAP, SAP_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07602 PSAP

Gene Names

PSAP, GLBA, SAP1

Chain

signal peptide:1-16, chain:17-524, propeptide:17-59, chain:60-142, propeptide:143-194, chain:195-274, chain:195-273, propeptide:275-310, chain:311-390, propeptide:393-404, chain:405-486, propeptide:487-524

Reference Genes

BioGPS Gene:5660 PSAP

COSMIC (genes):PSAP PSAP

CTD Gene:5660 PSAP

dbSNP Gene:5660 PSAP

ENSEMBL:ENSG00000197746 PSAP

ENSEMBL_homo_sapiens_GENE:ENSG00000197746.15 PSAP

HGNC:9498 PSAP

KEGG Gene (Homo sapiens):5660 PSAP

Monarch:5660 PSAP

NCBI Gene:5660 PSAP

OMIM:176801 PSAP

UCSC:P07602 PSAP

Reference Transcript

Other Identifiers

11739069_s_at

11752509_s_at

11752510_x_at

11755296_a_at

16715241

200866_PM_s_at

200866_s_at

200871_PM_s_at

200871_s_at

3293761

3293763

3293764

3293765

3293766

3293767

3293768

3293769

3293770

3293774

3293775

3293777

3293779

3293780

3293781

3293782

3293787

3293788

3293789

3293790

3293793

3293794

3293795

3293800

3293801

36795_at

5660

7934196

A_23_P12680

A_24_P309317

GE81192

GO:0002020

GO:0005515

GO:0005543

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005886

GO:0006629

GO:0006665

GO:0006914

GO:0007041

GO:0007193

GO:0008047

GO:0008289

GO:0010506

GO:0019216

GO:0022414

GO:0023052

GO:0030154

GO:0030312

GO:0031012

GO:0031410

GO:0035577

GO:0042802

GO:0042803

GO:0043202

GO:0043226

GO:0043231

GO:0048856

GO:0060736

GO:0060742

GO:0062023

GO:0070062

GO:0097110

GO:0098772

GO:1903771

GO:1905572

GO:1905573

GO:1905574

GO:1905575

GO:1905576

GO:1905577

HMNXSV003047545

ILMN_1749109

ILMN_2355559

J03077_s_at

PH_hs_0019280

TC10001374.hg

g11386146_3p_s_at

g337761_3p_a_at

Participates

as a component of

GBA1:SAPC [lysosomal membrane] (Homo sapiens)

as an output of

PSAP gets cleaved (Homo sapiens)

Other forms of this molecule

PSAP(60-142) [extracellular region]

PSAP(17-524) [plasma membrane]

PSAP(17-524) [azurophil granule membrane]

PSAP(311-391) [lysosomal lumen]

PSAP(405-486) [lysosomal lumen]

PSAP(60-142) [lysosomal lumen]

PSAP [lysosomal lumen]

PSAP(195-273) [lysosomal lumen]

PSAP(326-340) [extracellular region]

PSAP(?-?) [extracellular region]

Inferred To

PSAP(311-391) [lysosomal membrane] (Gallus gallus)

PSAP [lysosomal membrane] (Bos taurus)

PSAP [lysosomal membrane] (Canis familiaris)

PSAP [lysosomal membrane] (Sus scrofa)

spp-8 [lysosomal membrane] (Caenorhabditis elegans)

Sap-r [lysosomal membrane] (Drosophila melanogaster)

spp-10 [lysosomal membrane] (Caenorhabditis elegans)

Homologues of PSAP(311-391) [lysosomal membrane] (Caenorhabditis elegans)

sapA [lysosomal membrane] (Dictyostelium discoideum)

Psap [lysosomal membrane] (Mus musculus)

Psap [lysosomal membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_002769.1, NP_001035930.1, NP_001035931.1

OpenTargets

ENSG00000197746

HPA

ENSG00000197746-PSAP

GeneCards

P07602

Ensembl

ENSG00000197746, ENST00000394936, ENSP00000378394

PRO

P07602

Pharos - Targets

P07602

Orphanet

15159

HMDB Protein

HMDBP01673

PDB

2R0R, 3BQP, 2GTG, 1M12, 2Z9A, 2R1Q, 4V2O, 1N69, 8EQU, 3BQQ, 2QYP, 2RB3, 2DOB, 4DDJ, 1SN6, 4UEX, 6SLR

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.666	4
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.61	5
UniProt:P50542-3 PEX5			0.556	3
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:P31944 CASP14	2	CASP14(6-146) [cytosol] (R-HSA-8847667) CASP14(153-242) [cytosol] (R-HSA-8847687)	0.471	3

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