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PSAP(311-391) [lysosomal membrane]
Stable Identifier
R-HSA-1605602
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
SAPC, Saposin-C, SAP-2, Proactivator polypeptide component recommendedName: Saposin-A, PSAP, SAP_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide (Homo sapiens)
GBA:SAPC [lysosomal membrane] (Homo sapiens)
PSAP(311-391) [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07602 PSAP
Gene Names
PSAP, GLBA, SAP1
Chain
signal peptide:1-16, chain:17-524, propeptide:17-59, chain:60-142, propeptide:143-194, chain:195-274, chain:195-273, propeptide:275-310, chain:311-390, propeptide:393-404, chain:405-486, propeptide:487-524
Reference Genes
BioGPS Gene:5660 PSAP
COSMIC (genes):PSAP PSAP
CTD Gene:5660 PSAP
dbSNP Gene:5660 PSAP
ENSEMBL:ENSG00000197746 PSAP
HGNC:9498 PSAP
KEGG Gene (Homo sapiens):5660 PSAP
Monarch:5660 PSAP
NCBI Gene:5660 PSAP
OMIM:176801 PSAP
UCSC:P07602 PSAP
Reference Transcript
RefSeq:NM_002778.3 PSAP
RefSeq:NM_001042465.2 PSAP
RefSeq:NM_001042466.2 PSAP
Other Identifiers
0000510524
11739069_s_at
11752509_s_at
11752510_x_at
11755296_a_at
16715241
200866_s_at
200871_s_at
3293761
3293763
3293764
3293765
3293766
3293767
3293768
3293769
3293770
3293774
3293775
3293777
3293779
3293780
3293781
3293782
3293787
3293788
3293789
3293790
3293793
3293794
3293795
3293800
3293801
36795_at
5660
7934196
A_23_P12680
A_24_P309317
GE81192
GO:0000003
GO:0001664
GO:0001865
GO:0002020
GO:0002376
GO:0002576
GO:0003335
GO:0003674
GO:0004565
GO:0005515
GO:0005543
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005773
GO:0005886
GO:0006464
GO:0006629
GO:0006643
GO:0006664
GO:0006665
GO:0006672
GO:0006678
GO:0006683
GO:0006687
GO:0006810
GO:0006869
GO:0006886
GO:0006914
GO:0006950
GO:0007009
GO:0007034
GO:0007041
GO:0007165
GO:0007186
GO:0007193
GO:0007605
GO:0008047
GO:0008150
GO:0008219
GO:0008289
GO:0009056
GO:0009306
GO:0010506
GO:0015031
GO:0016192
GO:0016235
GO:0016798
GO:0019216
GO:0019882
GO:0019899
GO:0021702
GO:0022607
GO:0030154
GO:0030234
GO:0030882
GO:0031012
GO:0031410
GO:0034641
GO:0035577
GO:0040007
GO:0042552
GO:0042802
GO:0042803
GO:0043167
GO:0043202
GO:0043226
GO:0043231
GO:0043312
GO:0043408
GO:0043410
GO:0048589
GO:0048646
GO:0048856
GO:0050877
GO:0050885
GO:0051345
GO:0060073
GO:0060736
GO:0060742
GO:0061024
GO:0062023
GO:0070062
GO:0070841
GO:0071310
GO:0090102
GO:0090659
GO:1903206
GO:1903575
GO:1905146
GO:1905572
GO:1905573
GO:1905574
GO:1905575
GO:1905576
GO:1905577
ILMN_1749109
ILMN_2355559
J03077_s_at
PH_hs_0019280
TC10001374.hg
g11386146_3p_s_at
g337761_3p_a_at
Participant Of
hasComponent
GBA:SAPC [lysosomal membrane]
Other forms of this molecule
PSAP(60-142) [extracellular region]
PSAP(60-142) [lysosomal lumen]
PSAP(326-340) [extracellular region]
PSAP(?-?) [extracellular region]
PSAP(17-524) [azurophil granule membrane]
PSAP(17-524) [plasma membrane]
Inferred To
PSAP(311-391) [lysosomal membrane] (Gallus gallus)
PSAP [lysosomal membrane] (Canis familiaris)
Sap-r [lysosomal membrane] (Drosophila melanogaster)
sftpba [lysosomal membrane] (Danio rerio)
spp-10 [lysosomal membrane] (Caenorhabditis elegans)
Homologues of PSAP(311-391) [lysosomal membrane] (Gallus gallus)
LOC425940 [lysosomal membrane] (Gallus gallus)
Psap [lysosomal membrane] (Mus musculus)
Psap [lysosomal membrane] (Rattus norvegicus)
Cross References
RefSeq
NP_001035931.1
,
NP_001035930.1
,
NP_002769.1
Target Pathogen
5b354852be737e166372e745
OpenTargets
ENSG00000197746
HPA
ENSG00000197746-PSAP
GeneCards
P07602
Ensembl
ENSG00000197746
,
ENST00000394936
,
ENSP00000378394
PRO
P07602
Orphanet
15159
HMDB Protein
HMDBP01673
PDB
3BQP
,
1M12
,
4V2O
,
3BQQ
,
2DOB
,
4UEX
,
1SN6
,
2QYP
,
2RB3
,
2R1Q
,
2Z9A
,
2R0R
,
1N69
,
2GTG
,
4DDJ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.666
4
UniProt:P07948 LYN
5
LYN [cytosol]
(R-HSA-354251)
LYN [plasma membrane]
(R-HSA-197943)
p-Y396-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
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