Recruitment TBK1 to dsDNA:ZBP1 followed by its activation

Stable Identifier
R-HSA-1606324
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus, Human alphaherpesvirus 2
Compartment
cytosol
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Recruitment TBK1 to dsDNA:ZBP1 followed by its activation
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ZBP1 (DAI) dimer formation enables recruitment of TBK1 and IRF3 to the C-terminal region of DAI in response to cytosolic DNA in murine L929 cells. This interaction is DNA-dependent as ZBP1(DAI) mutants that lack DNA binding domains neither recruited TBK1 nor activated IRF3 (Takaoka A et al 2007). Activation of IRF-3 and possibly IRF-7 promotes IFN gene expression.

Literature References
PubMed ID Title Journal Year
17618271 DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Takaoka, A, Wang, Z, Choi, MK, Yanai, H, Negishi, H, Lu, Y, Ban, T, Miyagishi, M, Kodama, T, Honda, K, Ohba, Y, Taniguchi, T

Nature 2007
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Recruitment Tbk1 to dsDNA:Dai followed by its activation (Mus musculus)
Authored
Shamovsky, V  (2011-09-21)
Reviewed
D'Eustachio, P  (2011-12-08)
Upton, JW  (2012-02-19)
Mocarski, ES  (2012-02-19)
Created
Shamovsky, V  (2011-09-21)
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