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FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol]
Stable Identifier
R-HSA-1606443
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
FGFR1OP2-FGFR1 fusion, t(12;8) FGFR1OP2-FGFR1 fusion
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
Dimerization of cytosolic FGFR1 fusion proteins (Homo sapiens)
cytosolic FGFR1 fusion mutant dimers [cytosol] (Homo sapiens)
FGFR1OP2-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (Homo sapiens)
cytosolic FGFR1 fusion mutants [cytosol] (Homo sapiens)
FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (Homo sapiens)
Phosphorylation of cytosolic FGFR1 fusion dimers (Homo sapiens)
cytosolic FGFR1 fusion mutant dimers [cytosol] (Homo sapiens)
FGFR1OP2-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (Homo sapiens)
Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation (Homo sapiens)
FGFR1 fusion mutant dimers:TKIs [cytosol] (Homo sapiens)
cytosolic FGFR1 fusion mutant dimers [cytosol] (Homo sapiens)
FGFR1OP2-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (Homo sapiens)
cytosolic FGFR1 fusion mutant dimers [cytosol] (Homo sapiens)
FGFR1OP2-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15034873
Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome
Grand, FH
,
Grand, EK
,
Corcoran, MM
,
Chase, AJ
,
Cross, NC
,
Ross, FM
,
Oscier, DG
Genes Chromosomes Cancer
2004
External Reference Information
External Reference
UniProt:Q9NVK5 FGFR1OP2
Gene Names
FGFR1OP2, HSPC123
Chain
chain:1-253
Reference Genes
BioGPS Gene:26127 FGFR1OP2
COSMIC (genes):FGFR1OP2 FGFR1OP2
CTD Gene:26127 FGFR1OP2
dbSNP Gene:26127 FGFR1OP2
ENSEMBL:ENSG00000111790 FGFR1OP2
HGNC:23098 FGFR1OP2
Monarch:26127 FGFR1OP2
NCBI Gene:26127 FGFR1OP2
OMIM:608858 FGFR1OP2
UCSC:Q9NVK5 FGFR1OP2
Reference Transcript
RefSeq:NM_015633.2 FGFR1OP2
RefSeq:NM_001171887.1 FGFR1OP2
RefSeq:NM_001171888.1 FGFR1OP2
Other Identifiers
11736116_a_at
11744747_a_at
11744748_x_at
11763278_s_at
1556283_PM_s_at
1556283_s_at
16749365
223262_PM_s_at
223262_s_at
223263_PM_s_at
223263_s_at
233898_PM_s_at
233898_s_at
236808_PM_at
236808_at
243619_PM_at
243619_at
26127
3408968
3408969
3408970
3408975
3408977
3408978
3408979
3408982
3408983
3408984
3408985
3408986
3408987
3408988
3413954
3413955
45928_at
51604_at
51665_r_at
55360_at
57525_at
7954492
90948_at
A_14_P120800
A_14_P123610
A_23_P390734
A_24_P1545
A_33_P3369258
A_33_P3369262
GE56514
GE85762
GO:0005515
GO:0005737
GO:0005829
GO:0009611
GO:0042060
GO:0042802
HMNXSV003045942
Hs.173074.0.S2_3p_a_at
Hs.173074.1.S1_3p_a_at
Hs.269069.0.A1_3p_at
Hs.87298.0.A1_3p_at
ILMN_1657436
PH_hs_0033152
TC12000260.hg
g6841467_3p_a_at
Participates
as a member of
cytosolic FGFR1 fusion mutants [cytosol] (Homo sapiens)
as a component of
FGFR1OP2-FGFR1 fusion mutant dimer [cytosol] (Homo sapiens)
Other forms of this molecule
FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol]
Modified Residues
Name
Insertion of residues 429 to 822 at 133 from UniProt:P11362 FGFR1
Coordinate
133
Disease
Name
Identifier
Synonyms
subacute leukemia
DOID:3264
myelodysplastic myeloproliferative cancer
DOID:4972
Myeloproliferative/Myelodysplastic syndromes, unclassifiable myelodysplastic myeloproliferative disease, Unclassifiable Myeloproliferative/Myelodysplastic syndrome, Myelodysplastic/myeloproliferative disease (morphologic abnormality)
acute lymphocytic leukemia
DOID:9952
Cross References
ENSEMBL
ENST00000327214
,
ENST00000546072
,
ENSP00000229395
,
ENST00000229395
,
ENSP00000437556
,
ENSP00000323763
OpenTargets
ENSG00000111790
HPA
ENSG00000111790-FGFR1OP2
PRO
Q9NVK5
Pharos - Targets
Q9NVK5
GlyGen
Q9NVK5
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6E0 STK24
4
STK24 [cytosol]
(R-HSA-351829)
STK24(1-313) [cytosol]
(R-HSA-351892)
STK24(314-443) [cytosol]
(R-HSA-351898)
STK24(1-313) [nucleoplasm]
(R-HSA-351944)
0.643
3
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.643
4
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.643
5
UniProt:Q9BRV8 SIKE1
1
SIKE1 [cytosol]
(R-HSA-916828)
0.643
5
UniProt:O55106
1
Strn [cytosol]
(R-MMU-9037081)
0.536
3
UniProt:Q9P289 STK26
3
MST4(306-416) [cytosol]
(R-HSA-351903)
MST4(1-305) [cytosol]
(R-HSA-351855)
MST4 [cytosol]
(R-HSA-351918)
0.527
2
UniProt:Q13043 STK4
4
STK4(1-487) [cytosol]
(R-HSA-201627)
STK4(327-487) [cytosol]
(R-HSA-2028668)
p-T183-STK4(1-487) [cytosol]
(R-HSA-2028258)
p-T183-STK4(1-326) [cytosol]
(R-HSA-2028682)
0.483
2
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