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HEYL [nucleoplasm]
Stable Identifier
R-HSA-1606748
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Hairy/enhancer-of-split related with YRPW motif-like protein, Class B basic helix-loop-helix protein 33, Hairy-related transcription factor 3, BHLHB33, HRT3
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
Regulation of CDH11 Expression and Function (Homo sapiens)
Regulation of CDH11 gene transcription (Homo sapiens)
CDH11 gene is transcribed into nascent CDH11 mRNA (Homo sapiens)
HEYL [nucleoplasm] (Homo sapiens)
HEYL:CDH11 gene [nucleoplasm] (Homo sapiens)
HEYL [nucleoplasm] (Homo sapiens)
HEYL binds CDH11 gene promoter (Homo sapiens)
HEYL [nucleoplasm] (Homo sapiens)
HEYL:CDH11 gene [nucleoplasm] (Homo sapiens)
HEYL [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)
HEY [nucleoplasm] (Homo sapiens)
HEYL [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)
HEY [nucleoplasm] (Homo sapiens)
HEYL [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NOTCH1 stimulates HEY transcription (Homo sapiens)
HEY [nucleoplasm] (Homo sapiens)
HEYL [nucleoplasm] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
HEYL gene expression is stimulated by NOTCH3 (Homo sapiens)
HEYL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQ87 HEYL
Gene Names
HEYL, BHLHB33, HRT3
Chain
chain:1-328
Reference Genes
BioGPS Gene:26508 HEYL
COSMIC (genes):HEYL HEYL
CTD Gene:26508 HEYL
dbSNP Gene:26508 HEYL
ENSEMBL:ENSG00000163909 HEYL
HGNC:4882 HEYL
KEGG:hsa:26508 HEYL
Monarch:26508 HEYL
NCBI Gene:26508 HEYL
OMIM:609034 HEYL
UCSC:Q9NQ87 HEYL
Reference Transcript
RefSeq:NM_014571.3 HEYL
Other Identifiers
11722073_at
11722074_s_at
11722075_at
11748322_a_at
16685704
220662_PM_s_at
220662_s_at
226828_PM_s_at
226828_s_at
2407993
2407994
2407995
2407996
2407997
2407998
2407999
2408000
2408001
2408002
2408003
2408004
2408005
2408006
2408007
2408008
2408010
2408012
2408013
2408015
26508
43489_at
54852_at
61175_at
7915229
79778_at
A_23_P430658
GE55316
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0003151
GO:0003180
GO:0003181
GO:0003184
GO:0003198
GO:0003203
GO:0003208
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006355
GO:0006357
GO:0007219
GO:0009952
GO:0010629
GO:0014031
GO:0030154
GO:0032835
GO:0035914
GO:0042803
GO:0043226
GO:0043433
GO:0043565
GO:0045666
GO:0045892
GO:0045944
GO:0046983
GO:0048856
GO:0050683
GO:0050767
GO:0060317
GO:0060412
GO:0060766
GO:0071773
GO:0072014
GO:0072359
GO:0140110
HMNXSV003000908
Hs.23823.1.A1_3p_s_at
ILMN_1654324
PH_hs_0002098
TC01002543.hg
g7657153_3p_s_at
Participates
as an output of
HEYL gene expression is stimulated by NOTCH3 (Homo sapiens)
as a component of
HEYL:CDH11 gene [nucleoplasm] (Homo sapiens)
as an input of
HEYL binds CDH11 gene promoter (Homo sapiens)
as a member of
HEY [nucleoplasm] (Homo sapiens)
Inferred To
Hey [nucleoplasm]
(Drosophila melanogaster)
Heyl [nucleoplasm]
(Mus musculus)
Heyl [nucleoplasm]
(Rattus norvegicus)
hey1 [nucleoplasm]
(Danio rerio)
hey1 [nucleoplasm]
(Xenopus tropicalis)
cwo [nucleoplasm]
(Drosophila melanogaster)
HEYL [nucleoplasm]
(Bos taurus)
HEYL [nucleoplasm]
(Canis familiaris)
HEYL [nucleoplasm]
(Gallus gallus)
HEYL [nucleoplasm]
(Sus scrofa)
Homologues of HEYL [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_055386.1
ENSEMBL
ENST00000372852
,
ENSP00000361943
OpenTargets
ENSG00000163909
HPA
ENSG00000163909-HEYL
PRO
Q9NQ87
Pharos - Targets
Q9NQ87
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99750 MDFI
0.781
7
UniProt:Q93062 RBPMS
0.666
4
UniProt:Q3LI66 KRTAP6-2
1
KRTAP6-2 [cytosol]
(R-HSA-6810261)
0.556
3
UniProt:Q96CS7 PKHB2
0.556
3
UniProt:Q96KN7 RPGR1
0.556
3
UniProt:Q8N9N5-2 BANP
0.556
3
UniProt:Q8N8L6 ARL10
0.527
2
UniProt:P53609 PGTB1
0.527
3
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