Reactome | SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases

SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases

Stable Identifier

R-HSA-1614336

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

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SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases

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Sulfatase-modifying factor 2 (SUMF2, also called C-alpha-formylglycine-generating enzyme 2, pFGE) is the paralogue of SUMF1. While SUMF1 can modify a critical residue on arylsulfatases to confer activity to them, SUMF2 lacks this ability (Mariappan et al. 2005) and instead, SUMF2 can inhibit the action of SUMF1 by dimerising with it (Zito et al. 2005, Fraldi et al. 2008, Zito et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
15708861	Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme Balleininger, M, Eiselt, N, Preusser-Kunze, A, Mariappan, M, Gande, SL, von Figura, K, Wenzel, D, Dierks, T, Schmidt, B	J Biol Chem	2005
18508857	Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44 Cozzolino, M, Sitia, R, Monti, M, Fraldi, A, Cosma, MP, Zito, E, Spampanato, C, Pucci, P, Lombardi, A, Ballabio, A, Annunziata, F	Hum Mol Genet	2008
27909074	Sulfatase activities are regulated by the interaction of the sulfatase-modifying factor 1 with SUMF2 Pepe, S, Annunziata, I, Fraldi, A, Kobinger, G, Di Natale, P, Cosma, MP, Zito, E, Ballabio, A	EMBO Rep	2016
15962010	Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2 Fraldi, A, Pepe, S, Kobinger, G, Ballabio, A, Annunziata, I, Cosma, MP, Di Natale, P, Zito, E	EMBO Rep	2005