Excess cysteine yields lanthionine and H2S

Stable Identifier
R-HSA-1614591
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Excess homocysteine will change the enzymatic activity of CBS such that other reactions than transsulfuration take place. In these reactions, oxobutanoate, lanthionine, and homolanthionine are produced by cystathionine gamma-lyase (CTH) (Chiku et al. 2009, Steegborn et al. 1999)

Literature References
PubMed ID Title Journal Year
19261609 H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia

Chiku, T, Padovani, D, Zhu, W, Singh, S, Vitvitsky, V, Banerjee, R

J Biol Chem 2009
10212249 Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration

Steegborn, C, Clausen, T, Sondermann, P, Jacob, U, Worbs, M, Marinkovic, S, Huber, R, Wahl, MC

J Biol Chem 1999
Participants
Input
Participant Of
Catalyst Activity
Catalyst Activity
Title
L-cysteine desulfhydrase activity of PXLP-K212-CTH tetramer [cytosol]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
Authored
Reviewed
Created