Cysteine formation from homocysteine

Stable Identifier
R-HSA-1614603
Type
Pathway
Species
Homo sapiens
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Transsulfuration is the interconversion of homocysteine and cysteine, and it fully takes place in bacteria and some plants and fungi. Animals however have only one direction of this bidirectional path, the synthesis of cysteine from homocysteine via cystathionine. Because excess cysteine is degraded to hydrogen sulfide, which is now known as a neuromodulator and smooth muscle relaxant, this pathway is also the main source of its production, which takes place in the cytosol, as well as in extracellular space (Dominy & Stipanuk 2004, Bearden et al. 2010).

Literature References
PubMed ID Title Journal Year
15497768 New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant

Dominy, JE, Stipanuk, MH

Nutr Rev 2004
20817827 Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress

Bearden, SE, Beard RS, Jr, Pfau, JC

Am J Physiol Heart Circ Physiol 2010
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