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Sulfur amino acid metabolism
Stable Identifier
R-HSA-1614635
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
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The main sulfur amino acids are methionine, cysteine, homocysteine and taurine. Of these, the first two are proteinogenic.
This group of reactions contains all processes that 1) break down sulfur amino acids, 2) interconvert between them, and 3) synthesize them from solved sulfide which comes from sulfate assimilation and reduction. Only plants and microorganisms employ all processes. Humans cannot de novo synthesize any sulfur amino acid, nor convert cysteine to methionine (Brosnan & Brosnan, 2006).
Literature References
PubMed ID
Title
Journal
Year
16702333
The sulfur-containing amino acids: an overview
Brosnan, JT
,
Brosnan, ME
J Nutr
2006
Participants
Events
Methionine salvage pathway
(Homo sapiens)
MAT1A multimers transfer Ado from ATP to L-Met
(Homo sapiens)
MTR transfers CH3 from MeCbl to HCYS
(Homo sapiens)
AHCY:NAD+ tetramer hydrolyses AdoHcy
(Homo sapiens)
BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY
(Homo sapiens)
BHMT2 tetramer transfers CH3 group from SMM to LHCYS
(Homo sapiens)
Cysteine formation from homocysteine
(Homo sapiens)
Degradation of cysteine and homocysteine
(Homo sapiens)
Participates
as an event of
Metabolism of amino acids and derivatives (Homo sapiens)
Event Information
Go Biological Process
sulfur amino acid metabolic process (0000096)
Orthologous Events
Sulfur amino acid metabolism (Bos taurus)
Sulfur amino acid metabolism (Caenorhabditis elegans)
Sulfur amino acid metabolism (Canis familiaris)
Sulfur amino acid metabolism (Danio rerio)
Sulfur amino acid metabolism (Dictyostelium discoideum)
Sulfur amino acid metabolism (Drosophila melanogaster)
Sulfur amino acid metabolism (Gallus gallus)
Sulfur amino acid metabolism (Mus musculus)
Sulfur amino acid metabolism (Plasmodium falciparum)
Sulfur amino acid metabolism (Rattus norvegicus)
Sulfur amino acid metabolism (Saccharomyces cerevisiae)
Sulfur amino acid metabolism (Schizosaccharomyces pombe)
Sulfur amino acid metabolism (Sus scrofa)
Sulfur amino acid metabolism (Xenopus tropicalis)
Authored
Stephan, R (2010-10-24)
Reviewed
D'Eustachio, P (2011-10-13)
Created
Jassal, B (2011-09-29)
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