BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY

Stable Identifier
R-HSA-1614654
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Remethylation of homocysteine via betaine degradation
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Remethylation of homocysteine (HCYS) to methionine (L-Met) can also proceed by using betaine (BET) as a methyl donor, which is oxidised to dimethylglycine (DMGLY). This reaction is also part of choline catabolism, thereby providing a link to folate-dependent, one-carbon metabolism (Li et al. 2008).

Literature References
PubMed ID Title Journal Year
18457970 Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization

Li, F, Feng, Q, Lee, C, Wang, S, Pelleymounter, LL, Moon, I, Eckloff, BW, Wieben, ED, Schaid, DJ, Yee, V, Weinshilboum, RM

Mol Genet Metab 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
betaine-homocysteine S-methyltransferase activity of BHMT:Zn2+ tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created