Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
THEM4 [mitochondrial matrix]
Stable Identifier
R-HSA-162408
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
C-terminal modulator protein
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Mitochondrial Fatty Acid Beta-Oxidation (Homo sapiens)
ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)
ACOT2,9, THEM4,5 dimer [mitochondrial matrix] (Homo sapiens)
THEM4 dimer [mitochondrial matrix] (Homo sapiens)
THEM4 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5T1C6 THEM4
Gene Names
THEM4, CTMP
Chain
transit peptide:1-36, chain:37-240
Reference Genes
BioGPS Gene:117145 THEM4
COSMIC (genes):THEM4 THEM4
CTD Gene:117145 THEM4
dbSNP Gene:117145 THEM4
ENSEMBL:ENSG00000159445 THEM4
HGNC:17947 THEM4
KEGG:hsa:117145 THEM4
Monarch:117145 THEM4
NCBI Gene:117145 THEM4
OMIM:606388 THEM4
UCSC:Q5T1C6 THEM4
Reference Transcript
RefSeq:NM_053055.4 THEM4
Other Identifiers
117145
11743092_at
11758326_s_at
1553118_PM_at
1553118_at
16693259
229253_3p_at
229253_PM_at
229253_at
243492_PM_at
243492_at
2435343
2435344
2435345
2435346
2435348
2435349
2435350
2435351
2435352
2435353
2435354
2435355
2435356
2435357
2435359
2435360
2435361
2435362
2435363
2435364
2435367
2435368
2435369
2435370
2435376
2435377
2435378
3407914
3407925
3625404
3625405
55946_at
59980_at
68871_r_at
7920114
82092_at
A_24_P928510
A_32_P66674
A_33_P3343432
GE56901
GE86079
GO:0003824
GO:0005515
GO:0005737
GO:0005739
GO:0005743
GO:0005758
GO:0005759
GO:0005829
GO:0005886
GO:0006629
GO:0006631
GO:0006915
GO:0007005
GO:0012501
GO:0016787
GO:0032587
GO:0042995
GO:0043226
GO:0051898
GO:0052816
GO:0061024
GO:1902108
HMNXSV003010692
Hs.266155.0.A1_3p_x_at
Hs.293691.1.S1_3p_at
Hs.293691.1.S1_3p_x_at
Hs2.293691.1.S1_3p_x_at
ILMN_1682120
PH_hs_0029658
PH_hs_0032546
TC01003238.hg
Participates
as a component of
THEM4 dimer [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
THEM4 [cytosol]
THEM4 [plasma membrane]
Inferred To
LOC101735170 [mitochondrial matrix]
(Xenopus tropicalis)
THEM4 [mitochondrial matrix]
(Bos taurus)
THEM4 [mitochondrial matrix]
(Canis familiaris)
THEM4 [mitochondrial matrix]
(Dictyostelium discoideum)
THEM4 [mitochondrial matrix]
(Gallus gallus)
THEM4 [mitochondrial matrix]
(Mus musculus)
THEM4 [mitochondrial matrix]
(Rattus norvegicus)
Cross References
RefSeq
NP_444283.2
ENSEMBL
ENST00000368814
,
ENSP00000357804
OpenTargets
ENSG00000159445
IntEnz
3.1.2.2
HPA
ENSG00000159445-THEM4
PRO
Q5T1C6
Pharos - Targets
Q5T1C6
HMDB Protein
HMDBP11976
PDB
4GAH
,
4AE8
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
AKT1 [plasma membrane]
(R-HSA-199416)
AKT1 [cytosol]
(R-HSA-58252)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
0.734
4
UniProt:P08670 VIM
11
Vimentin [lysosomal lumen]
(R-HSA-9659977)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [late endosome lumen]
(R-HSA-9660019)
VIM [cytosol]
(R-HSA-201600)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
0.556
3
UniProt:P13196 ALAS1
2
PXLP-ALAS1 [mitochondrial matrix]
(R-HSA-1022086)
ALAS1 [mitochondrial matrix]
(R-HSA-189438)
0.527
2
UniProt:P11182 DBT
11
Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-70017)
Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859151)
Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859144)
2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859145)
LipoH2-K105-DBT [mitochondrial matrix]
(R-HSA-9859167)
DBT [mitochondrial matrix]
(R-HSA-6792584)
P276C Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865046)
S399C Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865036)
K313_Y338del Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865051)
I98M Lipo-K105-DBT [mitochondrial matrix]
(R-HSA-9865057)
DBT [cytosol]
(R-HSA-9714663)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text