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Cap Binding Complex (CBC) [cytosol]
Stable Identifier
R-HSA-162460
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Metabolism of non-coding RNA (Homo sapiens)
snRNP Assembly (Homo sapiens)
Nuclear export of snRNA transcripts (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
Cap Binding Complex (CBC) [cytosol] (Homo sapiens)
Participants
components
NCBP1 [cytosol]
(Homo sapiens)
NCBP2 [cytosol]
(Homo sapiens)
Participates
as an output of
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
Nuclear export of snRNA transcripts (Homo sapiens)
as a component of
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Homo sapiens)
mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Homo sapiens)
ROBO3.2 mRNA:CBC:EIF4G1:PABPC1 [cytosol] (Homo sapiens)
mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
as an input of
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Inferred To
Cap Binding Complex (CBC) [cytosol]
(Bos taurus)
Cap Binding Complex (CBC) [cytosol]
(Caenorhabditis elegans)
Cap Binding Complex (CBC) [cytosol]
(Canis familiaris)
Cap Binding Complex (CBC) [cytosol]
(Danio rerio)
Cap Binding Complex (CBC) [cytosol]
(Dictyostelium discoideum)
Cap Binding Complex (CBC) [cytosol]
(Drosophila melanogaster)
Cap Binding Complex (CBC) [cytosol]
(Gallus gallus)
Cap Binding Complex (CBC) [cytosol]
(Mus musculus)
Cap Binding Complex (CBC) [cytosol]
(Plasmodium falciparum)
Cap Binding Complex (CBC) [cytosol]
(Rattus norvegicus)
Cap Binding Complex (CBC) [cytosol]
(Saccharomyces cerevisiae)
Cap Binding Complex (CBC) [cytosol]
(Schizosaccharomyces pombe)
Cap Binding Complex (CBC) [cytosol]
(Sus scrofa)
Cap Binding Complex (CBC) [cytosol]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-1427
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