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RBM8A [cytosol]
Stable Identifier
R-HSA-162462
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RBM8A/Y14
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
Magoh-Y14 complex [cytosol] (Homo sapiens)
RBM8A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5S9 RBM8A
Gene Names
RBM8A, RBM8, HSPC114, MDS014
Chain
initiator methionine:, chain:2-174
Reference Genes
BioGPS Gene:9939 RBM8A
COSMIC (genes):RBM8A RBM8A
CTD Gene:9939 RBM8A
dbSNP Gene:9939 RBM8A
ENSEMBL:ENSG00000265241 RBM8A
ENSEMBL_homo_sapiens_GENE:ENSG00000265241.8 RBM8A
HGNC:9905 RBM8A
KEGG Gene (Homo sapiens):9939 RBM8A
Monarch:9939 RBM8A
NCBI Gene:9939 RBM8A
OMIM:605313 RBM8A
UCSC:Q9Y5S9 RBM8A
Reference Transcript
RefSeq:NM_005105.4 RBM8A
Other Identifiers
11717422_s_at
11717423_s_at
11758777_x_at
11763501_s_at
16669830
16669840
213852_PM_at
213852_at
214113_3p_s_at
214113_PM_s_at
214113_s_at
217856_PM_at
217856_at
217857_PM_s_at
217857_s_at
222443_PM_s_at
222443_s_at
2355705
2356182
2356183
2356188
2356191
2356193
2356195
2356197
2356198
2356199
2356200
2356201
2356202
2356203
2356204
2356206
2356207
2356208
2356209
2356210
3538612
3538613
3538614
3538615
3538616
3538617
3538618
40819_at
40820_at
64886_at
7904751
8180286
9939
A_14_P139097
A_23_P104116
A_24_P79955
A_32_P62571
GE58355
GE61533
GO:0000184
GO:0000381
GO:0000398
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0005737
GO:0005829
GO:0006396
GO:0006397
GO:0006406
GO:0006417
GO:0006913
GO:0008380
GO:0016071
GO:0016607
GO:0030425
GO:0035145
GO:0043025
GO:0043226
GO:0050684
GO:0051028
GO:0071006
GO:0071013
GO:1990501
GO:2000622
HMNXSV003033005
Hs.65648.0.S3_3p_at
Hs.65648.1.A1_3p_s_at
Hs.65648.2.A1_3p_at
ILMN_1781870
PH_hs_0030984
TC01001093.hg
g10197629_3p_s_at
g4826971_3p_s_at
Participates
as a component of
Magoh-Y14 complex [cytosol] (Homo sapiens)
Other forms of this molecule
RBM8A [nucleoplasm]
Inferred To
tsu [cytosol]
(Drosophila melanogaster)
Rbm8a [cytosol]
(Mus musculus)
Rbm8a [cytosol]
(Rattus norvegicus)
RBM8A [cytosol]
(Canis familiaris)
RBM8A [cytosol]
(Gallus gallus)
RBM8A [cytosol]
(Plasmodium falciparum)
RBM8A [cytosol]
(Schizosaccharomyces pombe)
RBM8A [cytosol]
(Sus scrofa)
rbm8a [cytosol]
(Danio rerio)
rbm8a [cytosol]
(Xenopus tropicalis)
rnp-4 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of RBM8A [cytosol]
(Bos taurus)
Ghost homologue of RBM8A [cytosol]
(Saccharomyces cerevisiae)
rbm8A [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_005096.1
OpenTargets
ENSG00000265241
HPA
ENSG00000265241-RBM8A
GeneCards
Q9Y5S9
Ensembl
ENSG00000265241
,
ENSP00000488265
,
ENSP00000510519
,
ENST00000632555
,
ENSP00000358313
,
ENST00000583313
,
ENST00000691760
,
ENSP00000463058
,
ENST00000369307
PRO
Q9Y5S9
Pharos - Targets
Q9Y5S9
Orphanet
21071
PDB
5XJC
,
7W59
,
7A5P
,
7ZNJ
,
3EX7
,
2XB2
,
7W5A
,
8C6J
,
2HYI
,
2J0S
,
7W5B
,
5YZG
,
1P27
,
2J0Q
,
6ICZ
,
6QDV
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.947
22
UniProt:Q9BZI7 UPF3B
2
UPF3B [nucleoplasm]
(R-HSA-156776)
UPF3B [cytosol]
(R-HSA-159258)
0.914
10
UniProt:O15234 CASC3
2
CASC3 [cytosol]
(R-HSA-927807)
CASC3 [nucleoplasm]
(R-HSA-8849148)
0.857
6
UniProt:Q92900 UPF1
2
UPF1 [cytosol]
(R-HSA-927734)
p-4S-UPF1 [cytosol]
(R-HSA-927856)
0.725
5
UniProt:P52298 NCBP2
2
NCBP2 [nucleoplasm]
(R-HSA-51463)
NCBP2 [cytosol]
(R-HSA-162458)
0.643
3
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.564
2
UniProt:Q13838 DDX39B
2
DDX39B [cytosol]
(R-HSA-9715154)
DDX39B [nucleoplasm]
(R-HSA-8849139)
0.527
3
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
4
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.527
2
UniProt:Q86V81 ALYREF
2
ALYREF [nucleoplasm]
(R-HSA-156649)
ALYREF [cytosol]
(R-HSA-158482)
0.527
2
UniProt:P62249 RPS16
2
RPS16 [nucleoplasm]
(R-HSA-6791196)
RPS16 [cytosol]
(R-HSA-72337)
0.527
2
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.512
3
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