Reactome | RBM8A [cytosol]

RBM8A [cytosol]

Stable Identifier

R-HSA-162462

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RBM8A/Y14

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Regulation of expression of SLITs and ROBOs (Homo sapiens)
        
        Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
        
        Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
        
        Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Transport of Mature Transcript to Cytoplasm (Homo sapiens)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
      - Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
      - mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
        
        EJC [cytosol] (Homo sapiens)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Homo sapiens)
        
        Magoh-Y14 complex [cytosol] (Homo sapiens)
        
        RBM8A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5S9 RBM8A

Gene Names

RBM8A, RBM8, HSPC114, MDS014

Chain

initiator methionine:, chain:2-174

Reference Genes

BioGPS Gene:9939 RBM8A

COSMIC (genes):RBM8A RBM8A

CTD Gene:9939 RBM8A

dbSNP Gene:9939 RBM8A

ENSEMBL:ENSG00000265241 RBM8A

ENSEMBL_homo_sapiens_GENE:ENSG00000265241.8 RBM8A

HGNC:9905 RBM8A

KEGG Gene (Homo sapiens):9939 RBM8A

Monarch:9939 RBM8A

NCBI Gene:9939 RBM8A

OMIM:605313 RBM8A

UCSC:Q9Y5S9 RBM8A

Reference Transcript

RefSeq:NM_005105.4 RBM8A

Other Identifiers

11717422_s_at

11717423_s_at

11758777_x_at

11763501_s_at

16669830

16669840

213852_PM_at

213852_at

214113_3p_s_at

214113_PM_s_at

214113_s_at

217856_PM_at

217856_at

217857_PM_s_at

217857_s_at

222443_PM_s_at

222443_s_at

2355705

2356182

2356183

2356188

2356191

2356193

2356195

2356197

2356198

2356199

2356200

2356201

2356202

2356203

2356204

2356206

2356207

2356208

2356209

2356210

3538612

3538613

3538614

3538615

3538616

3538617

3538618

40819_at

40820_at

64886_at

7904751

8180286

9939

A_14_P139097

A_23_P104116

A_24_P79955

A_32_P62571

GE58355

GE61533

GO:0000184

GO:0000381

GO:0000398

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005737

GO:0005829

GO:0006396

GO:0006397

GO:0006406

GO:0006417

GO:0006913

GO:0008380

GO:0016071

GO:0016607

GO:0030425

GO:0035145

GO:0043025

GO:0043226

GO:0050684

GO:0051028

GO:0071006

GO:0071013

GO:0110165

GO:1990501

GO:2000622

HMNXSV003033005

Hs.65648.0.S3_3p_at

Hs.65648.1.A1_3p_s_at

Hs.65648.2.A1_3p_at

ILMN_1781870

PH_hs_0030984

TC01001093.hg

g10197629_3p_s_at

g4826971_3p_s_at

Participates

as a component of

Magoh-Y14 complex [cytosol] (Homo sapiens)

Other forms of this molecule

RBM8A [nucleoplasm]

Inferred To

tsu [cytosol] (Drosophila melanogaster)

Rbm8a [cytosol] (Mus musculus)

Rbm8a [cytosol] (Rattus norvegicus)

RBM8A [cytosol] (Canis familiaris)

RBM8A [cytosol] (Gallus gallus)

RBM8A [cytosol] (Plasmodium falciparum)

RBM8A [cytosol] (Schizosaccharomyces pombe)

RBM8A [cytosol] (Sus scrofa)

rbm8a [cytosol] (Danio rerio)

rbm8a [cytosol] (Xenopus tropicalis)

rnp-4 [cytosol] (Caenorhabditis elegans)

Ghost homologue of RBM8A [cytosol] (Bos taurus)

Ghost homologue of RBM8A [cytosol] (Saccharomyces cerevisiae)

rbm8A [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_005096.1

OpenTargets

ENSG00000265241

HPA

ENSG00000265241-RBM8A

GeneCards

Q9Y5S9

Ensembl

ENST00000583313, ENST00000369307, ENSP00000488265, ENSP00000510519, ENST00000691760, ENSP00000358313, ENSP00000463058, ENST00000632555, ENSG00000265241

PRO

Q9Y5S9

Pharos - Targets

Q9Y5S9

Orphanet

21071

PDB

7W5A, 8C6J, 7W5B, 5XJC, 7ZNJ, 6ICZ, 5YZG, 1P27, 7W59, 2J0Q, 7A5P, 3EX7, 6QDV, 2XB2, 2J0S, 2HYI

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.921	21
UniProt:Q9BZI7 UPF3B	2	UPF3B [nucleoplasm] (R-HSA-156776) UPF3B [cytosol] (R-HSA-159258)	0.914	10
UniProt:O15234 CASC3	2	CASC3 [nucleoplasm] (R-HSA-8849148) CASC3 [cytosol] (R-HSA-927807)	0.813	5
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.643	3
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.527	2
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.512	3

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