Reactome | p-Y546,Y584-PTPN11 [cytosol]

p-Y546,Y584-PTPN11 [cytosol]

Stable Identifier

R-HSA-162573

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p(Y546,584)-SHP2, Tyrosine phosphorylated SHP2, PTPN11

Icon

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
        
        p-Y546,Y584-PTPN11 [cytosol] (Homo sapiens)
        
        Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
        
        p-Y546,Y584-PTPN11 [cytosol] (Homo sapiens)
        
        Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
        
        p-Y546,Y584-PTPN11 [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
        
        p-Y546,Y584-PTPN11 [cytosol] (Homo sapiens)
        
        Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
        
        p-Y546,Y584-PTPN11 [cytosol] (Homo sapiens)
        
        Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
        
        p-Y546,Y584-PTPN11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q06124 PTPN11

Gene Names

PTPN11, PTP2C, SHPTP2

Chain

initiator methionine:1, chain:2-593

Reference Genes

BioGPS Gene:5781 PTPN11

COSMIC (genes):PTPN11 PTPN11

CTD Gene:5781 PTPN11

dbSNP Gene:5781 PTPN11

ENSEMBL:ENSG00000179295 PTPN11

HGNC:9644 PTPN11

KEGG Gene (Homo sapiens):5781 PTPN11

Monarch:5781 PTPN11

NCBI Gene:5781 PTPN11

OMIM:176876 PTPN11

UCSC:Q06124 PTPN11

Reference Transcript

Other Identifiers

0000940170

11729206_at

11729207_s_at

11729208_x_at

11761200_at

1552637_PM_at

1552637_at

16757255

1870_at

1871_g_at

205867_PM_at

205867_at

205868_PM_s_at

205868_s_at

209895_PM_at

209895_at

209896_PM_s_at

209896_s_at

212610_PM_at

212610_at

2687514

2775657

2851175

3136729

3136745

3432334

3432340

3432342

3432343

3432344

3432345

3432350

3432351

3432352

3432353

3432354

3432357

3432358

3432359

3432360

3432365

3432367

3432368

3432369

3432370

3432371

3432372

3432373

3432374

3432375

3432376

38443_at

5781

7958846

A_14_P201950

A_23_P204090

A_23_P99027

A_32_P61757

D13540_at

GE59447

GE79583

GO:0000003

GO:0000077

GO:0000278

GO:0000902

GO:0001784

GO:0002376

GO:0003674

GO:0004721

GO:0004725

GO:0004726

GO:0005158

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006470

GO:0006629

GO:0006641

GO:0006810

GO:0006913

GO:0006950

GO:0007049

GO:0007155

GO:0007165

GO:0007173

GO:0007229

GO:0007267

GO:0007409

GO:0007420

GO:0007507

GO:0008150

GO:0008543

GO:0009755

GO:0009967

GO:0015031

GO:0016311

GO:0016787

GO:0016791

GO:0019221

GO:0019899

GO:0019901

GO:0021697

GO:0022607

GO:0030154

GO:0030159

GO:0030220

GO:0030674

GO:0030971

GO:0031295

GO:0032331

GO:0032528

GO:0032728

GO:0032755

GO:0032760

GO:0032991

GO:0033277

GO:0033628

GO:0033629

GO:0035264

GO:0035265

GO:0035335

GO:0035855

GO:0036302

GO:0038127

GO:0040007

GO:0040011

GO:0042445

GO:0042592

GO:0042593

GO:0043226

GO:0043254

GO:0043408

GO:0045296

GO:0045778

GO:0045931

GO:0046326

GO:0046628

GO:0046676

GO:0046825

GO:0046887

GO:0046888

GO:0048008

GO:0048011

GO:0048013

GO:0048609

GO:0048646

GO:0048806

GO:0048839

GO:0048856

GO:0048870

GO:0048873

GO:0050731

GO:0050839

GO:0051428

GO:0051463

GO:0055085

GO:0060020

GO:0060125

GO:0060325

GO:0060338

GO:0061582

GO:0065003

GO:0070374

GO:0071364

GO:1990782

HMNXSV003024186

Hs.83572.0.S1_3p_at

Hs2.22868.1.S1_3p_at

ILMN_1778236

PH_hs_0027176

TC12000881.hg

TC12002571.hg

U79291_at

g13430845_3p_at

g292406_3p_a_at

g7770146_RC_3p_at

Participates

as a component of

Other forms of this molecule

p-Y546-PTPN11 [cytosol]

PTPN11 [nucleoplasm]

PTPN11 [cytosol]

Inferred To

phospho-ptpn11 [cytosol] (Xenopus tropicalis)

Ghost homologue of p-Y546,Y584-PTPN11 [cytosol] (Danio rerio)

Ghost homologue of p-Y546,Y584-PTPN11 [cytosol] (Drosophila melanogaster)

phospho-PTPN11 [cytosol] (Bos taurus)

phospho-PTPN11 [cytosol] (Canis familiaris)

phospho-PTPN11 [cytosol] (Gallus gallus)

phospho-PTPN11 [cytosol] (Sus scrofa)

phospho-Ptpn11 [cytosol] (Mus musculus)

phospho-Ptpn11 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 546

Coordinate

546

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 584

Coordinate

584

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002825.3, NP_542168.1, NP_001317366.1

ZINC - World Drugs

PTN11_HUMAN

OpenTargets

ENSG00000179295

ZINC - Substances

PTN11_HUMAN

ZINC target

Q06124

ZINC - Biogenic

PTN11_HUMAN

PRO

Q06124

PDB

4GWF, 4RDD, 6MDC, 6BMV, 6CRF, 7R7D, 7R75, 4H1O, 5IBM, 6CMS, 6MDB, 4JMG, 3ZM1, 6CMQ, 4OHH, 5X7B, 5EHP, 5BK8, 6WU8, 6CMR, 2SHP, 7RCT, 7EMN, 7R7I, 5X94, 4OHD, 4H34, 6BMX, 4DGX, 4OHE, 6CMP, 3ZM3, 6BMU, 3O5X, 5I6V, 6MDD, 3TKZ, 6BMW, 4DGP, 6R5G, 4JE4, 4OHL, 6MDA, 5XZR, 6BMR, 6ATD, 7JVN, 5IBS, 7JVM, 3ZM2, 4JEG, 6MD7, 4QSY, 4OHI, 4NWG, 4PVG, 3MOW, 3B7O, 5EHR, 6MD9, 3ZM0, 5DF6, 6CRG, 3TL0, 6BMY, 4NWF, 6BN5, 7R7L

ZINC - Metabolites

PTN11_HUMAN

IntEnz

3.1.3.48

HPA

ENSG00000179295-PTPN11

GeneCards

Q06124

Ensembl

ENST00000635625, ENST00000351677, ENSG00000179295, ENST00000392597, ENSP00000489597, ENSP00000340944, ENSP00000376376

Pharos - Targets

Q06124

Orphanet

15170

ZINC - Predictions - Purchasable

PTN11_HUMAN

HMDB Protein

HMDBP08926

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.953	42
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.902	8
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.893	10
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.772	7
UniProt:P80200 CGA1			0.77	8
UniProt:Q13049 TRIM32	1	TRIM32 [cytosol] (R-HSA-976030)	0.742	5
UniProt:P08069 IGF1R	3	p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180)	0.712	4
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.69	7
UniProt:P20138 CD33	3	CD33 [specific granule membrane] (R-HSA-6799615) CD33 [plasma membrane] (R-HSA-197719) CD33 [tertiary granule membrane] (R-HSA-6800959)	0.677	5
UniProt:P49247 RPIA	2	RPIA A61V [cytosol] (R-HSA-5660009) RPIA [cytosol] (R-HSA-71304)	0.666	4
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) p-Y-Irs1 [cytosol] (R-RNO-112362) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.656	3
UniProt:Q8WU20 FRS2	6	p-Y-FRS2 [cytosol] (R-HSA-162551) FRS2 [cytosol] (R-HSA-190244) p-6Y-FRS2 [cytosol] (R-HSA-190355) p-8T-FRS2 [plasma membrane] (R-HSA-1270462) FRS2 [plasma membrane] (R-HSA-170963) p-6Y-FRS2 [plasma membrane] (R-HSA-170959)	0.649	4
UniProt:Q9UQC2 GAB2	5	p-Y-GAB2 [cytosol] (R-HSA-912529) GAB2 [cytosol] (R-HSA-508239) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y643-GAB2 [cytosol] (R-HSA-9677149)	0.643	4
UniProt:P32239 CCKBR	1	CCKBR [plasma membrane] (R-HSA-388515)	0.623	5
UniProt:P08581 MET	7	p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.609	13
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.604	3
UniProt:Q15116 PDCD1	2	PDCD1 [plasma membrane] (R-HSA-197604) p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736)	0.602	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.592	3
UniProt:Q08345 DDR1	1	DDR1 [plasma membrane] (R-HSA-2327723)	0.576	4
UniProt:P29317 EPHA2	2	EPHA2 [plasma membrane] (R-HSA-211422) p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380)	0.573	2
UniProt:Q15303 ERBB4			0.573	2
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.564	2
UniProt:O95297 MPZL1			0.564	4
UniProt:P97710 Sirpa	9	pSirpa_Rat [plasma membrane] (R-RNO-548918) Sirpa_Rat [plasma membrane] (R-RNO-548921) phospho-Sirpa [plasma membrane] (R-RNO-391102) Sirpa [plasma membrane] (R-RNO-197571-6) Sirpa [tertiary granule membrane] (R-RNO-6803288) Sirpa [plasma membrane] (R-RNO-3209922) Sirpa [ficolin-1-rich granule membrane] (R-RNO-6803321) Sirpa [plasma membrane] (R-RNO-197568-6) Sirpa [secretory granule membrane] (R-RNO-6804801-6)	0.564	3
UniProt:P68105 EEF1A1	1	reEF1A [cytosol] (R-OCU-159543)	0.544	2
UniProt:P04040 CAT	5	CAT [cytosol] (R-HSA-9033141) CAT [secretory granule lumen] (R-HSA-6801311) CAT [extracellular region] (R-HSA-6806458) CAT [ficolin-1-rich granule lumen] (R-HSA-6801279) CAT [peroxisomal matrix] (R-HSA-51417)	0.544	3
UniProt:P48357 LEPR			0.527	2
UniProt:P32927 CSF2RB	6	p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.525	5
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.499	2
UniProt:P43626 KIR2DL1	1	KIR2DL1 [plasma membrane] (R-HSA-199538)	0.488	2
UniProt:P43628 KIR2DL3	1	KIR2DL3 [plasma membrane] (R-HSA-3006532)	0.462	4
UniProt:Q13291 SLAF1			0.462	2
UniProt:Q9Y3P8 SIT1			0.462	2
UniProt:P36888 FLT3	20	FLT3 F691I [plasma membrane] (R-HSA-9702900) FLT3 N676D [plasma membrane] (R-HSA-9702895) FLT3 R834Q [plasma membrane] (R-HSA-9691899) FLT3 Y572C [plasma membrane] (R-HSA-9691902) FLT3 A848P [plasma membrane] (R-HSA-9702909) FLT3 A627P [plasma membrane] (R-HSA-9699448) FLT3 F621L [plasma membrane] (R-HSA-9699426) p-Y768,Y969 FLT3 [plasma membrane] (R-HSA-9698405) Ub-pY FLT3 [endosome membrane] (R-HSA-9706174) Ub-pY FLT3 [plasma membrane] (R-HSA-9706171) FLT3 V592G [plasma membrane] (R-HSA-9691071) FLT3 Y589_F590insFYVDFREYEYDLKWEF [plasma membrane] (R-HSA-9697939) FLT3 F590G Y591D [plasma membrane] (R-HSA-9691062) FLT3 F594L [plasma membrane] (R-HSA-9691058) FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] (R-HSA-9699433) FLT3 V579A [plasma membrane] (R-HSA-9691051) FLT3 Y599_D600insGLYVDFREYEY [plasma membrane] (R-HSA-9696044) FLT3 Y591_V592insVDFREDREHH [plasma membrane] (R-HSA-9696043) FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane] (R-HSA-9690076) FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] (R-HSA-9696033)	0.462	2

Cite Us!