Early Phase of HIV Life Cycle

Stable Identifier
R-HSA-162594
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
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General
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In the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins. HIV RNA genome is reverse transcribed by the viral Reverse Transcriptase to form a cDNA copy, that gets inserted into host cell DNA. The viral Integrase enzyme is vital to carry out the integration of the viral cDNA into the host genome. The host DNA repair enzymes probably repair the breaks in DNA at the sites of integration.

Literature References
PubMed ID Title Journal Year
12091904 Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

Greene, WC, Peterlin, BM

Nat Med 2002
Participants
Participant Of
hasEvent
Event Information
Go Biological Process
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created