uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid

Stable Identifier
R-HSA-162729
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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The fatty acid group added to inositol in the fourth step of GPI biosynthsis is removed from GPI-conjugated uPAR. This hydrolysis event occurs in the endoplasmic reticulum and appears to be associated with efficient transport of the conjugated protein from the endoplasmic reticulum to the Golgi apparatus (Tanaka et al. 2004).
Participants
Participates
Catalyst Activity

hydrolase activity, acting on ester bonds of PGAP1 [endoplasmic reticulum membrane]

Orthologous Events
Authored
Created
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