uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide

Stable Identifier
R-HSA-162836
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In the endoplasmic reticulum, the precursor form of urokinase plasminogen activator receptor is transamidated at residue 305, replacing the 30 carboxyterminal residues of the protein with an acylated glucosylphosphatidylinositol (acyl-GPI) moiety. The released carboxyterminal propeptide has no known function. The reaction is catalyzed by GPI transamidase, a complex of at least five proteins associated with the lumenal surface of the endoplasmic reticulum membrane (Yu et al. 1997; Ohishi et al. 2001; Hong et al. 2003).

Literature References
PubMed ID Title Journal Year
12802054 Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins

Hong, Y, Ohishi, K, Kang, JY, Tanaka, S, Inoue, N, Nishimura, J, Maeda, Y, Kinoshita, T

Mol Biol Cell 2003
9356492 The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

Yu, J, Nagarajan, S, Knez, JJ, Udenfriend, S, Chen, R, Medof, ME

Proc Natl Acad Sci U S A 1997
11483512 PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8

Ohishi, K, Inoue, N, Kinoshita, T

EMBO J 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GPI-anchor transamidase activity of GPI transamidase [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored