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UCHL5
Stable Identifier
R-HSA-1629778
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH37
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)
ADRM1:26S proteasome:UCHL5 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGF-beta family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
UCHL5/USP15 [cytosol] (Homo sapiens)
UCHL5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5K5 UCHL5
Gene Names
UCHL5, UCH37, AD-019, CGI-70
Chain
chain:1-329
Reference Genes
BioGPS Gene:51377 UCHL5
COSMIC (genes):UCHL5 UCHL5
CTD Gene:51377 UCHL5
dbSNP Gene:51377 UCHL5
ENSEMBL:ENSG00000116750 UCHL5
ENSEMBL:ENSG00000116750 UCHL5
HGNC:19678 UCHL5
KEGG Gene (Homo sapiens):hsa:51377 UCHL5
Monarch:51377 UCHL5
NCBI Gene:51377 UCHL5
OMIM:610667 UCHL5
UCSC:Q9Y5K5 UCHL5
Reference Transcript
RefSeq:NM_001199262.1 UCHL5
RefSeq:NM_001199261.1 UCHL5
RefSeq:NM_015984.3 UCHL5
RefSeq:NM_001199263.1 UCHL5
Other Identifiers
0005900369
11725084_a_at
11751587_a_at
11751588_x_at
11759748_x_at
11759770_a_at
11759771_x_at
16697438
219960_s_at
220083_x_at
229248_at
2448989
2448990
2448991
2448992
2448993
2448994
2448995
2448999
2449000
2449003
2449004
2449006
2449007
2449008
2449012
2449014
2449015
2449016
2449019
2449021
2449027
2449028
2449029
2449030
2449031
3A7S
3IHR
3RII
3RIS
3TB3
43928_at
4UEL
4UEM
4UF5
4UF6
4WLP
51377
55307_at
58417_at
5908
6069
75383
7923007
88396_at
91209_at
A_23_P148798
A_24_P188325
A_32_P38242
AAD31528
AAD34065
AAF67486
AAH15521
AAH25369
AAP35436
AF147717
AF151828
AF157320
AL136370
BC015521
BC025369
BT006790
CCDS1378
CCDS55668
CCDS55669
CCDS55670
ENSG00000116750
ENSP00000356418
ENSP00000356419
ENSP00000356424
ENSP00000356425
ENST00000367448
ENST00000367449
ENST00000367454
ENST00000367455
EntrezGene:51377
g7706307_3p_at
g7706752_3p_a_at
GO:0000228
GO:0000502
GO:0003674
GO:0003723
GO:0004843
GO:0004866
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006259
GO:0006281
GO:0006310
GO:0006351
GO:0006355
GO:0006464
GO:0006508
GO:0006511
GO:0006950
GO:0006974
GO:0008150
GO:0008233
GO:0008234
GO:0009056
GO:0009058
GO:0010951
GO:0016579
GO:0016787
GO:0021670
GO:0030234
GO:0030901
GO:0031011
GO:0031597
GO:0034641
GO:0036459
GO:0043226
GO:0043234
GO:0048853
GO:0048856
GO:0061136
GO:0070628
HGNC:19678
HPA005908
HPA006069
HPA075383
Hs.25223.0.A1_3p_at
ILMN_1731612
IPR001578
IPR017390
IPR033837
IPR036959
MIM:610667
NM_001199261
NM_001199262
NM_001199263
NM_001350844
NM_001350846
NM_001350847
NM_001350848
NM_001350849
NM_001350850
NM_001350851
NM_015984
NP_001186190
NP_001186191
NP_001186192
NP_001337773
NP_001337775
NP_001337776
NP_001337777
NP_001337778
NP_001337779
NP_001337780
NP_057068
PF01088
PH_hs_0022056
PH_hs_0036882
PR00707
TC01003650.hg
TC01006015.hg
uc001gsm.4
uc001gso.4
uc001gsp.4
uc001gsq.4
UCHL5
UCHL5-201
UCHL5-202
UCHL5-205
UCHL5-206
UPI0000070EBB
UPI0000073ABB
UPI000013CF2A
UPI000046F8DB
XM_005245246
XM_005245247
XM_005245248
XM_006711367
XM_006711368
XM_006711369
XM_011509604
XM_017001429
XM_017001430
XM_017001431
XM_017001432
XM_017001433
XM_017001435
XM_017001436
XM_017001437
XP_005245303
XP_006711430
XP_006711432
XP_011507906
XP_016856919
XP_016856920
XP_016856921
XP_016856922
XP_016856925
XP_016856926
XR_001737214
XR_001737215
XR_001737216
XR_001737217
XR_001737218
XR_001737219
XR_921823
Participant Of
hasMember
UCHL5/USP15 [cytosol]
input
ADRM1:26S proteaseome binds UCHL5
hasComponent
ADRM1:26S proteasome:UCHL5 [cytosol]
Other forms of this molecule
UCHL5 [nucleoplasm]
Inferred To
Homologues of UCHL5 [cytosol] (Arabidopsis thaliana)
Homologues of UCHL5 [cytosol] (Drosophila melanogaster)
Homologues of UCHL5 [cytosol] (Gallus gallus)
Homologues of UCHL5 [cytosol] (Oryza sativa)
Homologues of UCHL5 [cytosol] (Rattus norvegicus)
Homologues of UCHL5 [cytosol] (Sus scrofa)
Uchl5 [cytosol] (Mus musculus)
UCHL5 [cytosol] (Arabidopsis thaliana)
UCHL5 [cytosol] (Bos taurus)
UCHL5 [cytosol] (Caenorhabditis elegans)
UCHL5 [cytosol] (Canis familiaris)
UCHL5 [cytosol] (Danio rerio)
UCHL5 [cytosol] (Dictyostelium discoideum)
UCHL5 [cytosol] (Drosophila melanogaster)
UCHL5 [cytosol] (Gallus gallus)
UCHL5 [cytosol] (Oryza sativa)
UCHL5 [cytosol] (Plasmodium falciparum)
UCHL5 [cytosol] (Rattus norvegicus)
UCHL5 [cytosol] (Schizosaccharomyces pombe)
UCHL5 [cytosol] (Sus scrofa)
UCHL5 [cytosol] (Taeniopygia guttata)
UCHL5 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001186191.1
,
NP_057068.1
,
NP_001186192.1
,
NP_001186190.1
GeneCards
Q9Y5K5
DOCK Blaster
3RII
,
3IHR
,
3RIS
,
4UF6
,
3TB3
,
4WLP
,
4UEM
,
4UEL
,
4UF5
,
3A7S
ZINC target
Q9Y5K5
PRO
Q9Y5K5
BRENDA (Homo sapiens)
3.4.19.12
PDB
4UEL
,
3IHR
,
3TB3
,
4UF5
,
4UEM
,
4UF6
,
4WLP
,
3RIS
,
3A7S
,
3RII
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.959
20
UniProt:Q6P4R8 NFRKB
1
NFRKB [nucleoplasm]
(R-HSA-5689578)
0.807
12
UniProt:P55036 PSMD4
2
PSMD4 [cytosol]
(R-HSA-68800)
PSMD4 [nucleoplasm]
(R-HSA-174330)
0.77
5
UniProt:Q13200 PSMD2
5
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.758
5
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.723
7
UniProt:O00232 PSMD12
5
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [cytosol]
(R-HSA-68792)
0.669
4
UniProt:O00231 PSMD11
5
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [cytosol]
(R-HSA-68790)
0.669
4
UniProt:P51665 PSMD7
5
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [cytosol]
(R-HSA-68806)
0.669
4
UniProt:P49720 PSMB3
2
PSMB3 [cytosol]
(R-HSA-68747)
PSMB3 [nucleoplasm]
(R-HSA-174341)
0.669
3
UniProt:P48556 PSMD8
2
PSMD8 [cytosol]
(R-HSA-68808)
PSMD8 [nucleoplasm]
(R-HSA-174318)
0.669
4
UniProt:P43686 PSMC4
2
PSMC4 [cytosol]
(R-HSA-68777)
PSMC4 [nucleoplasm]
(R-HSA-174315)
0.669
4
UniProt:P17980 PSMC3
5
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [cytosol]
(R-HSA-68774)
0.669
4
UniProt:P60900 PSMA6
2
PSMA6 [cytosol]
(R-HSA-68734)
PSMA6 [nucleoplasm]
(R-HSA-174314)
0.669
4
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.669
4
UniProt:P35998 PSMC2
5
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [cytosol]
(R-HSA-68771)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
0.669
4
UniProt:P62191 PSMC1
2
PSMC1 [nucleoplasm]
(R-HSA-174338)
PSMC1 [cytosol]
(R-HSA-68768)
0.669
4
UniProt:P62195 PSMC5
2
PSMC5 [nucleoplasm]
(R-HSA-174312)
PSMC5 [cytosol]
(R-HSA-68780)
0.669
5
UniProt:Q15008 PSMD6
5
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [cytosol]
(R-HSA-68804)
0.669
4
UniProt:O43242 PSMD3
5
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [cytosol]
(R-HSA-68798)
0.669
4
UniProt:O00487 PSMD14
5
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
0.669
4
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.641
3
UniProt:O75832 PSMD10
2
PSMD10 [cytosol]
(R-HSA-68788)
PSMD10 [nucleoplasm]
(R-HSA-174322)
0.564
2
UniProt:P28074 PSMB5
2
PSMB5 [cytosol]
(R-HSA-68753)
PSMB5 [nucleoplasm]
(R-HSA-174344)
0.564
3
UniProt:P28072 PSMB6
2
PSMB6 [cytosol]
(R-HSA-68756)
PSMB6 [nucleoplasm]
(R-HSA-174342)
0.564
3
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.564
3
UniProt:Q99460 PSMD1
4
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [extracellular region]
(R-HSA-6806194)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [cytosol]
(R-HSA-68786)
0.564
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:P28070 PSMB4
2
PSMB4 [cytosol]
(R-HSA-68750)
PSMB4 [nucleoplasm]
(R-HSA-174343)
0.527
3
UniProt:O14818 PSMA7
2
PSMA7 [cytosol]
(R-HSA-68736)
PSMA7 [nucleoplasm]
(R-HSA-174351)
0.527
3
UniProt:Q99436 PSMB7
5
PSMB7 [extracellular region]
(R-HSA-6806449)
PSMB7 [ficolin-1-rich granule lumen]
(R-HSA-6803312)
PSMB7 [secretory granule lumen]
(R-HSA-6803279)
PSMB7 [nucleoplasm]
(R-HSA-174331)
PSMB7 [cytosol]
(R-HSA-68759)
0.527
2
UniProt:P49721 PSMB2
2
PSMB2 [cytosol]
(R-HSA-68744)
PSMB2 [nucleoplasm]
(R-HSA-174335)
0.527
3
UniProt:P20618 PSMB1
5
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
PSMB1 [nucleoplasm]
(R-HSA-174347)
PSMB1 [cytosol]
(R-HSA-68738)
0.527
3
UniProt:P28066 PSMA5
5
PSMA5 [extracellular region]
(R-HSA-6806459)
PSMA5 [ficolin-1-rich granule lumen]
(R-HSA-6803328)
PSMA5 [secretory granule lumen]
(R-HSA-6803316)
PSMA5 [nucleoplasm]
(R-HSA-174340)
PSMA5 [cytosol]
(R-HSA-68732)
0.527
3
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.527
3
UniProt:P25787 PSMA2
5
PSMA2 [extracellular region]
(R-HSA-6806506)
PSMA2 [ficolin-1-rich granule lumen]
(R-HSA-6803285)
PSMA2 [secretory granule lumen]
(R-HSA-6803329)
PSMA2 [nucleoplasm]
(R-HSA-174345)
PSMA2 [cytosol]
(R-HSA-68726)
0.527
3
UniProt:P25788 PSMA3
2
PSMA3 [cytosol]
(R-HSA-68728)
PSMA3 [nucleoplasm]
(R-HSA-174323)
0.527
3
UniProt:Q9UNM6 PSMD13
5
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [cytosol]
(R-HSA-68794)
0.527
3
UniProt:P25789 PSMA4
2
PSMA4 [cytosol]
(R-HSA-68730)
PSMA4 [nucleoplasm]
(R-HSA-174324)
0.527
3
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.527
2
UniProt:Q9H981 ACTR8
1
ACTR8 [nucleoplasm]
(R-HSA-5689565)
0.499
3
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