Reactome | UCHL5 [cytosol]

UCHL5 [cytosol]

Stable Identifier

R-HSA-1629778

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH37

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y5K5 UCHL5

Gene Names

UCHL5, UCH37, AD-019, CGI-70

Chain

chain:1-329

Reference Genes

BioGPS Gene:51377 UCHL5

COSMIC (genes):UCHL5 UCHL5

CTD Gene:51377 UCHL5

dbSNP Gene:51377 UCHL5

ENSEMBL:ENSG00000116750 UCHL5

HGNC:19678 UCHL5

KEGG Gene (Homo sapiens):51377 UCHL5

Monarch:51377 UCHL5

NCBI Gene:51377 UCHL5

OMIM:610667 UCHL5

UCSC:Q9Y5K5 UCHL5

Reference Transcript

Other Identifiers

0005900369

11725084_a_at

11751587_a_at

11751588_x_at

11759748_x_at

11759770_a_at

11759771_x_at

16697438

219960_s_at

220083_x_at

229248_at

2448989

2448990

2448991

2448992

2448993

2448994

2448995

2448998

2448999

2449000

2449003

2449004

2449006

2449007

2449008

2449012

2449014

2449015

2449016

2449019

2449021

2449027

2449028

2449029

2449030

2449031

2449032

3A7S

3IHR

3RII

3RIS

3TB3

43928_at

4UEL

4UEM

4UF5

4UF6

4WLP

51377

55307_at

58417_at

5908

6069

75383

7923007

88396_at

91209_at

A_23_P148798

A_24_P188325

A_32_P38242

AAD31528

AAD34065

AAF67486

AAH15521

AAH25369

AAP35436

AF147717

AF151828

AF157320

AL136370

BC015521

BC025369

BT006790

CCDS1378

CCDS55668

CCDS55669

CCDS55670

ENSG00000116750

ENSP00000356418

ENSP00000356419

ENSP00000356424

ENSP00000356425

ENST00000367448

ENST00000367448.5

ENST00000367449

ENST00000367449.5

ENST00000367454

ENST00000367454.5

ENST00000367455

ENST00000367455.8

EntrezGene:51377

EntrezGene:UCHL5

g7706307_3p_at

g7706752_3p_a_at

GE62771

GO:0000228

GO:0000502

GO:0003674

GO:0003723

GO:0004843

GO:0004866

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0006259

GO:0006281

GO:0006310

GO:0006464

GO:0006508

GO:0006511

GO:0006950

GO:0006974

GO:0008150

GO:0008233

GO:0008234

GO:0009056

GO:0010951

GO:0016579

GO:0016787

GO:0030234

GO:0031011

GO:0032435

GO:0032991

GO:0034641

GO:0036459

GO:0043226

GO:0061136

GO:0070628

HGNC:19678

HPA005908

HPA006069

HPA075383

Hs.25223.0.A1_3p_at

ILMN_1731612

IPR001578

IPR017390

IPR033837

IPR036959

IPR038765

IPR041507

MIM:610667

NM_001199261

NM_001199262

NM_001199263

NM_001350843

NM_001350844

NM_001350845

NM_001350846

NM_001350847

NM_015984

NP_001186190

NP_001186191

NP_001186192

NP_001337772

NP_001337773

NP_001337774

NP_001337775

NP_001337776

NP_057068

NR_146931

PF01088

PF18031

PH_hs_0022056

PH_hs_0036882

PR00707

Q5LJA5

Q5LJA9

Q5LJB0

Q5LJB1

TC01003650.hg

TC01006015.hg

UCHL5

UCHL5-201

UCHL5-202

UCHL5-205

UCHL5-206

UPI0000070EBB

UPI0000073ABB

UPI000013CF2A

UPI000046F8DB

XM_005245246

XM_006711367

XM_006711369

XM_011509604

XM_017001430

XM_017001431

XM_017001432

XM_017001433

XM_017001436

XP_005245303

XP_006711430

XP_006711432

XP_011507906

XP_016856919

XP_016856920

XP_016856921

XP_016856922

XP_016856925

XR_001737214

XR_001737217

XR_001737218

XR_001737219

XR_002956782

XR_002956783

XR_921823

Participant Of

hasComponent

ADRM1:26S proteasome:UCHL5 [cytosol]

input

ADRM1:26S proteaseome binds UCHL5

hasMember

UCHL5/USP15 [cytosol]

Other forms of this molecule

UCHL5 [nucleoplasm]

Inferred To

uchl5 [cytosol] (Danio rerio)

Uch-L5 [cytosol] (Drosophila melanogaster)

uch2 [cytosol] (Dictyostelium discoideum)

uch2 [cytosol] (Schizosaccharomyces pombe)

Uchl5 [cytosol] (Mus musculus)

Uchl5 [cytosol] (Rattus norvegicus)

UCHL5 [cytosol] (Bos taurus)

UCHL5 [cytosol] (Canis familiaris)

UCHL5 [cytosol] (Gallus gallus)

UCHL5 [cytosol] (Plasmodium falciparum)

UCHL5 [cytosol] (Sus scrofa)

UCHL5 [cytosol] (Xenopus tropicalis)

ubh-4 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001186191.1, NP_001186192.1, NP_001186190.1, NP_057068.1

OpenTargets

ENSG00000116750

IntEnz

3.4.19.12

HPA

ENSG00000116750-UCHL5

GeneCards

Q9Y5K5

Ensembl

ENST00000367455, ENSP00000356419, ENST00000367454, ENST00000367449, ENST00000367448, ENSG00000116750, ENSP00000356418, ENSP00000356425, ENSP00000356424

ZINC target

Q9Y5K5

PRO

Q9Y5K5

PDB

4UEL, 4WLP, 3IHR, 3RIS, 3A7S, 3TB3, 4UF5, 3RII, 4UF6, 4UEM

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.961	21
UniProt:Q6P4R8 NFRKB	1	NFRKB [nucleoplasm] (R-HSA-5689578)	0.807	12
UniProt:P55036 PSMD4	2	PSMD4 [cytosol] (R-HSA-68800) PSMD4 [nucleoplasm] (R-HSA-174330)	0.77	5
UniProt:Q13200 PSMD2	5	PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.758	5
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.723	7
UniProt:O00232 PSMD12	5	PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.669	4
UniProt:O00231 PSMD11	5	PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.669	4
UniProt:P51665 PSMD7	5	PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.669	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.669	3
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.669	4
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.669	4
UniProt:P17980 PSMC3	5	PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.669	4
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.669	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.669	4
UniProt:P35998 PSMC2	5	PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.669	4
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.669	4
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.669	5
UniProt:Q15008 PSMD6	5	PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.669	4
UniProt:O43242 PSMD3	5	PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.669	4
UniProt:P0C1Z6 TFPT	1	TFPT [nucleoplasm] (R-HSA-5689542)	0.641	3
UniProt:O75832 PSMD10	2	PSMD10 [cytosol] (R-HSA-68788) PSMD10 [nucleoplasm] (R-HSA-174322)	0.564	2
UniProt:P28074 PSMB5	2	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344)	0.564	3
UniProt:P28072 PSMB6	2	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342)	0.564	3
UniProt:Q99460 PSMD1	4	PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.564	3
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.564	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:P28070 PSMB4	2	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343)	0.527	3
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.527	3
UniProt:Q99436 PSMB7	5	PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.527	2
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	3
UniProt:P20618 PSMB1	5	PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.527	3
UniProt:P28066 PSMA5	5	PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [cytosol] (R-HSA-68732)	0.527	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.527	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.527	3
UniProt:P25787 PSMA2	5	PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.527	3
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.527	3
UniProt:Q9UNM6 PSMD13	5	PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.527	3
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.527	3
UniProt:Q9H981 ACTR8	1	ACTR8 [nucleoplasm] (R-HSA-5689565)	0.499	3

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