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SMC4 [nucleoplasm]
Stable Identifier
R-HSA-1629795
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Structural maintenance of chromosomes protein 4, SMC protein 4, SMC-4, Chromosome-associated polypeptide C, hCAP-C, XCAP-C homolog, CAPC, SMC4L1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Condensation of Prophase Chromosomes (Homo sapiens)
CDK1 phosphorylates condensin II subunit NCAPD3 (Homo sapiens)
Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
Condensin II:RB1 [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)
Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Hyperphosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
MCPH1 sequesters condensin II (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
Condensin II:MCPH1:SET [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
PLK1 binds phosphorylated condensin II complex (Homo sapiens)
Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
PLK1 hyperphosphorylates Condensin II complex (Homo sapiens)
Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Hyperphosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
RB1 binds condensin II (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
Condensin II:RB1 [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
SMC4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NTJ3 SMC4
Gene Names
SMC4, CAPC, SMC4L1
Chain
chain:1-1288
Reference Genes
BioGPS Gene:10051 SMC4
COSMIC (genes):SMC4 SMC4
CTD Gene:10051 SMC4
dbSNP Gene:10051 SMC4
ENSEMBL:ENSG00000113810 SMC4
HGNC:14013 SMC4
KEGG:hsa:10051 SMC4
Monarch:10051 SMC4
NCBI Gene:10051 SMC4
OMIM:605575 SMC4
UCSC:Q9NTJ3 SMC4
Reference Transcript
RefSeq:XM_011512311.2 SMC4
RefSeq:NM_005496.3 SMC4
RefSeq:NM_001288753.1 SMC4
RefSeq:NM_001002800.2 SMC4
Other Identifiers
10051
11733874_a_at
11733875_a_at
11733876_x_at
11754320_a_at
16947556
16947603
16947605
201663_PM_s_at
201663_s_at
201664_PM_at
201664_at
215623_PM_x_at
215623_x_at
2650201
2650202
2650203
2650204
2650205
2650206
2650207
2650208
2650209
2650210
2650211
2650212
2650213
2650215
2650216
2650217
2650219
2650220
2650221
2650222
2650223
2650226
2650227
2650228
2650229
2650230
2650231
2650232
2650233
2650234
2650235
2650237
2650238
2650239
2650240
2650242
2650243
2650244
2650245
2650246
2650247
2650248
2650249
2650252
2650254
2650255
2650256
2650258
2650259
2650260
2650261
2650262
2650263
2650264
34878_at
44051_at
8083709
8083737
8083739
A_14_P104480
A_14_P112145
A_14_P117098
A_23_P327643
A_23_P91900
A_33_P3248519
A_33_P3716128
GE56658
GO:0000070
GO:0000228
GO:0000775
GO:0000794
GO:0000796
GO:0003677
GO:0003682
GO:0003697
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0007059
GO:0007076
GO:0010032
GO:0016607
GO:0016787
GO:0016887
GO:0022414
GO:0030261
GO:0043226
GO:0045132
GO:0051276
GO:0051301
GO:0051383
GO:0051984
GO:1905820
GO:1905821
HMNXSV003024933
HMNXSV003034482
HMNXSV003039997
Hs.50758.1.A1_3p_at
ILMN_1683302
ILMN_2251804
ILMN_2330861
PH_hs_0003499
PH_hs_0032198
TC03000873.hg
TC03000874.hg
TC03000875.hg
g4885112_3p_a_at
g6807670_3p_at
Participates
as a component of
Hyperphosphorylated Condensin II [nucleoplasm] (Homo sapiens)
Phosphorylated Condensin II [nucleoplasm] (Homo sapiens)
Condensin II [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SMC4 [cytosol]
p-S-SMC4 [cytosol]
Inferred To
Smc4 [nucleoplasm]
(Rattus norvegicus)
SMC4 [nucleoplasm]
(Bos taurus)
SMC4 [nucleoplasm]
(Canis familiaris)
SMC4 [nucleoplasm]
(Gallus gallus)
SMC4 [nucleoplasm]
(Mus musculus)
SMC4 [nucleoplasm]
(Sus scrofa)
Ghost homologue of SMC4 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of SMC4 [nucleoplasm]
(Danio rerio)
Ghost homologue of SMC4 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of SMC4 [nucleoplasm]
(Plasmodium falciparum)
Cross References
RefSeq
NP_005487.3
,
NP_001275682.1
,
XP_011510613.1
,
NP_001002800.1
ENSEMBL
ENST00000357388
,
ENSP00000349961
,
ENST00000462787
,
ENST00000344722
,
ENSP00000420734
,
ENSP00000341382
OpenTargets
ENSG00000113810
HPA
ENSG00000113810-SMC4
PRO
Q9NTJ3
Pharos - Targets
Q9NTJ3
GlyGen
Q9NTJ3
PDB
4U4P
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.669
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
11
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