Reactome | WDR5 [nucleoplasm]

WDR5 [nucleoplasm]

Stable Identifier

R-HSA-1629838

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, BIG3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P61964 WDR5

Gene Names

WDR5, BIG3

Chain

initiator methionine:1, chain:2-334

Reference Genes

BioGPS Gene:11091 WDR5

COSMIC (genes):WDR5 WDR5

CTD Gene:11091 WDR5

dbSNP Gene:11091 WDR5

ENSEMBL:ENSG00000196363 WDR5

HGNC:12757 WDR5

KEGG Gene (Homo sapiens):11091 WDR5

Monarch:11091 WDR5

NCBI Gene:11091 WDR5

OMIM:609012 WDR5

UCSC:P61964 WDR5

Reference Transcript

Other Identifiers

0002640131

0002640239

11091

11718374_at

11718375_x_at

11718376_s_at

17090893

223308_s_at

225170_at

2724381

43017_at

43018_g_at

43410_at

43411_g_at

78481_at

8159111

89596_at

A_23_P32558

A_33_P3292417

GE55545

GO:0000123

GO:0001501

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005671

GO:0005975

GO:0006325

GO:0006464

GO:0008150

GO:0008168

GO:0009058

GO:0016746

GO:0030154

GO:0031175

GO:0032991

GO:0035064

GO:0035097

GO:0042393

GO:0042800

GO:0043226

GO:0043687

GO:0043966

GO:0043981

GO:0043982

GO:0043984

GO:0043995

GO:0043996

GO:0044281

GO:0044666

GO:0045652

GO:0045722

GO:0046972

GO:0048188

GO:0048856

GO:0051276

GO:0051568

GO:0051571

GO:0051572

GO:0071339

Hs.13889.0.S1_3p_at

Hs.13889.0.S1_3p_x_at

Hs.323518.0.S1_3p_s_at

ILMN_1728626

ILMN_1737087

PH_hs_0028321

TC09000781.hg

Participant Of

hasMember

DCAF protein [nucleoplasm]

hasComponent

input

WDR5 binds Me2sR3-replicative histone H3

Inferred To

wdr5 [nucleoplasm] (Danio rerio)

wdr5 [nucleoplasm] (Dictyostelium discoideum)

wdr5 [nucleoplasm] (Xenopus tropicalis)

swd3 [nucleoplasm] (Schizosaccharomyces pombe)

Wdr5 [nucleoplasm] (Mus musculus)

Wdr5 [nucleoplasm] (Rattus norvegicus)

SWD3 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of WDR5 [nucleoplasm] (Bos taurus)

WDR5 [nucleoplasm] (Canis familiaris)

WDR5 [nucleoplasm] (Sus scrofa)

wds [nucleoplasm] (Drosophila melanogaster)

WDR5B [nucleoplasm] (Gallus gallus)

wdr-5.1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_060058.1, XP_005272220.1, NP_438172.1

OpenTargets

ENSG00000196363

HPA

ENSG00000196363-WDR5

ZINC - Substances

WDR5_HUMAN

GeneCards

P61964

ZINC target

P61964

Ensembl

ENST00000358625, ENSG00000196363, ENSP00000351446

PRO

P61964

Orphanet

25037

ZINC - Predictions - Purchasable

WDR5_HUMAN

PDB

5EAP, 4EWR, 4A7J, 6D9X, 3UVN, 6U6W, 6DAS, 2H9M, 4IA9, 3N0E, 4CY2, 6PGE, 6U8L, 6PG5, 4QL1, 6E1Z, 2H6K, 6PG6, 4GM3, 2GNQ, 6PGF, 3EMH, 4Y7R, 6PG9, 4GMB, 2H9L, 3UVM, 6PG8, 5EAM, 6U80, 6PGC, 3PSL, 3N0D, 6DAR, 4CY1, 6KIV, 6PG4, 4ERZ, 6E1Y, 5SXM, 6DAK, 5VFC, 6KIZ, 2G99, 6PWW, 3UVL, 4GM9, 6U5Y, 5EAL, 2G9A, 2H13, 6BYN, 6PGB, 2CO0, 2CNX, 6DYA, 5M25, 4ERY, 2H6N, 3UR4, 6E23, 6KIU, 6PGD, 2H6Q, 2O9K, 6PWV, 6U8O, 2H68, 5EAR, 4GM8, 4O45, 4ESG, 3UVO, 6IAM, 6PGA, 6UCS, 3P4F, 6U8B, 3SMR, 6KIW, 6PG3, 2H9N, 2H14, 2H9P, 4ERQ, 6U5M, 6DY7, 4ES0, 6E22, 5M23, 6KIX, 6PG7, 3MXX, 6UFX, 3UVK, 3EG6, 6DAI

Interactors (72)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.955	13
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.944	14
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.932	13
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.899	8
UniProt:Q7Z3B3 KANSL1	1	KANSL1 [nucleoplasm] (R-HSA-3321875)	0.848	11
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.823	9
UniProt:Q9UMN6 KMT2B	1	KMT2B [nucleoplasm] (R-HSA-1183216)	0.81	6
UniProt:Q03933 HSF2			0.781	7
UniProt:O14686 KMT2D	1	KMT2D [nucleoplasm] (R-HSA-1183219)	0.773	7
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.758	7
UniProt:Q9NS73 MBIP	1	MBIP [nucleoplasm] (R-HSA-3662291)	0.743	5
UniProt:Q2QGD7 ZXDC			0.743	5
UniProt:P68431 H3C1	59	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) HIST1H3A [extracellular region] (R-HSA-977570) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) AcK15-HIST1H3A [nucleoplasm] (R-HSA-4568743) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5229050) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4754188) Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4754169) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791) Me3K80-HIST1H3A [nucleoplasm] (R-HSA-5649795) Me2K80-HIST1H3A [nucleoplasm] (R-HSA-5649768) Me3K37-HIST1H3A [nucleoplasm] (R-HSA-5638160) Me2K37-HIST1H3A [nucleoplasm] (R-HSA-4722125) MeK10-HIST1H3A [nucleoplasm] (R-HSA-212105) MeK28-HIST1H3A [nucleoplasm] (R-HSA-5638327) MeK-10-HIST1H3A [cytosol] (R-HSA-8943830) HIST1H3A [cytosol] (R-HSA-8943829) Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-5244526) MeK5-HIST1H3A [nucleoplasm] (R-HSA-4687016) Cit27-HIST1H3A [nucleoplasm] (R-HSA-5246532) Cit3-HIST1H3A [nucleoplasm] (R-HSA-5246544) Cit9-HIST1H3A [nucleoplasm] (R-HSA-5246530) Cit18-HIST1H3A [nucleoplasm] (R-HSA-5246534) MeR18-HIST1H3A [nucleoplasm] (R-HSA-5229059) MeR3-HIST1H3A [nucleoplasm] (R-HSA-5244529) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5244801) MeR9-HIST1H3A [nucleoplasm] (R-HSA-5244806) Ack10-HIST1H3A [nucleoplasm] (R-HSA-4568939) Me2K5,Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-8936572) Me2K10-HIST1H3A [nucleoplasm] (R-HSA-427378) p-T12-HIST1H3A [nucleoplasm] (R-HSA-5625872) p-T12,MeK-10-HIST1H3A [nucleoplasm] (R-HSA-5625859) Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-427734) p-T12, Me2K-10-HIST1H3A [nucleoplasm] (R-HSA-5625790) p-T12, Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-5625757) Me3K5-HIST1H3A [nucleoplasm] (R-HSA-1214186) HIST1H3A [nucleoplasm] (R-HSA-212070) Me3K-28-HIST1H3A [nucleoplasm] (R-HSA-212220) Me2K5-HIST1H3A [nucleoplasm] (R-HSA-1214170)	0.74	11
IntAct:EBI-15650351 H3TAIL			0.734	5
UniProt:O15047 SETD1A	1	SETD1A [nucleoplasm] (R-HSA-3239027)	0.725	4
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.708	5
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.69	4
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.69	5
UniProt:Q9NS73-5 MBIP			0.666	4
UniProt:Q6PEV8 F199X			0.666	4
UniProt:P54259 ATN1	1	ATN1 [nucleoplasm] (R-HSA-6807083)	0.659	3
UniProt:Q9H9L4 KANSL2	1	KANSL2 [nucleoplasm] (R-HSA-3321796)	0.656	3
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.643	3
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.643	3
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.643	5
UniProt:Q9UPS6 SETD1B	1	SETD1B [nucleoplasm] (R-HSA-5244714)	0.643	3
UniProt:Q9BTK6 PAGR1	1	PAGR1 [nucleoplasm] (R-HSA-5619374)	0.643	4
UniProt:Q8NEZ4 KMT2C	1	KMT2C [nucleoplasm] (R-HSA-1183224)	0.623	4
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.623	3
UniProt:Q9H7Z6 KAT8	1	KAT8 [nucleoplasm] (R-HSA-3321802)	0.597	4
UniProt:Q7Z434-1 MAVS			0.591	3
UniProt:O43823 AKAP8			0.576	3
UniProt:Q9D1P2	1	Kat8 [nucleoplasm] (R-MMU-3321802)	0.564	2
UniProt:O15151 MDM4	5	PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) MDM4 [nucleoplasm] (R-HSA-349430)	0.556	3
UniProt:A7MD48 SRRM4			0.556	3
UniProt:O76083-2 PDE9A			0.556	3
UniProt:Q9Y4F3 MARF1			0.556	6
UniProt:A2RRG2 A2RRG2			0.556	3
UniProt:Q9Y5X4 NR2E3			0.556	5
UniProt:Q9H891 Q9H891			0.556	3
UniProt:Q92794 KAT6A	3	p-T369-KAT6A [nucleoplasm] (R-HSA-6805633) KAT6A (1-1118) [nucleoplasm] (R-HSA-5603260) KAT6A [nucleoplasm] (R-HSA-480310)	0.556	4
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:Q9UJX6 ANAPC2	2	ANAPC2 [cytosol] (R-HSA-174229) ANAPC2 [nucleoplasm] (R-HSA-174141)	0.556	3
UniProt:P10074 TZAP			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q96PG8 BBC3B			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
IntAct:EBI-15662162 H3-8			0.544	2
UniProt:P58004 SESN2	1	SESN2 [cytosol] (R-HSA-5629143)	0.527	2
UniProt:O00255 MEN1	4	MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901) MEN1 [cytosol] (R-HSA-5672315) MEN1 [nucleoplasm] (R-HSA-2186626)	0.527	2
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.527	2
UniProt:O75461 E2F6	2	p-S12-E2F6 [nucleoplasm] (R-HSA-9007536) E2F6 [nucleoplasm] (R-HSA-8953089)	0.527	3
UniProt:Q6UXN9 WDR82			0.527	2
UniProt:Q9ULM3 YEATS2	1	YEATS2 [nucleoplasm] (R-HSA-3321976)	0.527	2
UniProt:Q9P2R6 RERE			0.527	2
UniProt:O15294 OGT	1	OGT [nucleoplasm] (R-HSA-3321845)	0.527	3
UniProt:Q6ZSY5 PPR3F			0.527	2
UniProt:P19784 CSNK2A2	2	CSNK2A2 [nucleoplasm] (R-HSA-6805065) CSNK2A2 [cytosol] (R-HSA-201721)	0.527	2
UniProt:Q8NFC6 BD1L1			0.527	2
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.527	3
UniProt:O15550 KDM6A	1	KDM6A [nucleoplasm] (R-HSA-4754224)	0.527	4
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.527	2
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.527	2
UniProt:Q9Y5Z7 HCFC2			0.527	2
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.527	2
UniProt:Q6NZQ4 Paxip1	2	Paxip1 [nucleoplasm] (R-MMU-5619395) Paxip1 [nucleoplasm] (R-MMU-5619398)	0.527	3
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) SUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.527	2
UniProt:Q9BVI0 PHF20	3	p-S291-PHF20 [nucleoplasm] (R-HSA-6805776) p-S291-PHF20 [cytosol] (R-HSA-6805794) PHF20 [nucleoplasm] (R-HSA-3222239)	0.527	2
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [plasma membrane] (R-HSA-936955) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845)	0.524	2
UniProt:Q13114 TRAF3	5	K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-5668444) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.524	2
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:Q9WTL8 Arntl	2	p-S-Arntl [nucleoplasm] (R-MMU-508690) Arntl [cytosol] (R-MMU-508660)	0.508	2