Reactome | DKC1 [nucleoplasm]

DKC1 [nucleoplasm]

Stable Identifier

R-HSA-163102

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Dyskerin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O60832 DKC1

Gene Names

DKC1, NOLA4

Chain

initiator methionine:1, chain:2-514

Reference Genes

BioGPS Gene:1736 DKC1

COSMIC (genes):DKC1 DKC1

CTD Gene:1736 DKC1

dbSNP Gene:1736 DKC1

ENSEMBL:ENSG00000130826 DKC1

HGNC:2890 DKC1

KEGG Gene (Homo sapiens):1736 DKC1

Monarch:1736 DKC1

NCBI Gene:1736 DKC1

OMIM:300126 DKC1

UCSC:O60832 DKC1

Reference Transcript

Other Identifiers

0000940452

11743467_at

11743468_at

11757159_at

17108500

17119802

1736

201478_s_at

201479_at

216212_s_at

34829_at

3996668

3996669

3996671

3996672

3996673

3996674

3996675

3996676

3996677

3996680

3996683

3996684

3996685

3996686

3996687

3996688

3996689

3996691

3996693

3996694

3996695

3996696

3996698

8170971

8170992

A_14_P126139

A_21_P0000338

A_23_P137143

A_32_P91906

GE54597

GO:0000455

GO:0000495

GO:0001522

GO:0001650

GO:0003674

GO:0003720

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005697

GO:0005730

GO:0005737

GO:0006259

GO:0006364

GO:0006396

GO:0007004

GO:0008150

GO:0009056

GO:0009058

GO:0009451

GO:0009982

GO:0015030

GO:0016779

GO:0016853

GO:0031118

GO:0031120

GO:0031429

GO:0032212

GO:0032991

GO:0033979

GO:0034513

GO:0034641

GO:0034655

GO:0042254

GO:0042592

GO:0043226

GO:0051276

GO:0051973

GO:0070034

GO:0072589

GO:0090661

GO:0090666

GO:0090669

GO:1904851

GO:1904871

GO:1904872

GO:1904874

GO:1990481

Hs.4747.1.S1_3p_a_at

ILMN_1671257

ILMN_3240280

PH_hs_0000480

TC0X000779.hg

g2737893_3p_a_at

g4503336_3p_at

Participant Of

hasComponent

input

Inferred To

dkc1 [nucleoplasm] (Danio rerio)

cbf5 [nucleoplasm] (Schizosaccharomyces pombe)

Nop60B [nucleoplasm] (Drosophila melanogaster)

Dkc1 [nucleoplasm] (Mus musculus)

Dkc1 [nucleoplasm] (Rattus norvegicus)

nola4 [nucleoplasm] (Dictyostelium discoideum)

DKC1 [nucleoplasm] (Bos taurus)

DKC1 [nucleoplasm] (Caenorhabditis elegans)

DKC1 [nucleoplasm] (Canis familiaris)

DKC1 [nucleoplasm] (Gallus gallus)

DKC1 [nucleoplasm] (Plasmodium falciparum)

DKC1 [nucleoplasm] (Sus scrofa)

DKC1 [nucleoplasm] (Xenopus tropicalis)

CBF5 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001275676.1, NP_001354.1, NP_001135935.1

Target Pathogen

5b354852be737e166372eb41

OpenTargets

ENSG00000130826

GeneCards

O60832

HPA

ENSG00000130826-DKC1

Ensembl

ENST00000620277, ENSG00000130826, ENSP00000358563, ENSP00000478387, ENST00000369550

PRO

O60832

Orphanet

15869

HMDB Protein

HMDBP01675

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96HR8 NAF1			0.826	8
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.774	9
UniProt:Q9BUR4 WRAP53	2	Unfolded WRAP53 [cytosol] (R-HSA-6813830) WRAP53 [nucleoplasm] (R-HSA-418386)	0.723	6
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.69	7
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.669	3
UniProt:Q9NPE3 NOP10	1	NOP10 [nucleoplasm] (R-HSA-6790665)	0.669	3
UniProt:Q6PI26 SHQ1	1	SHQ1 [nucleoplasm] (R-HSA-9671152)	0.564	2
UniProt:Q9NY12 GAR1	1	GAR1 [nucleoplasm] (R-HSA-6790707)	0.527	2
UniProt:Q6NT76 HMBX1			0.499	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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