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DKC1 [nucleoplasm]
Stable Identifier
R-HSA-163102
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Dyskerin
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Biogenesis and assembly of the telomerase RNP (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
DKC1 binds SHQ1 (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
DKC1:SHQ1 [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Elongation Of The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Elongation of Extended Telomeric Chromosome End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Telomerase RNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
rRNA modification in the nucleus and cytosol (Homo sapiens)
Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA (Homo sapiens)
Box H/ACA snoRNP [nucleoplasm] (Homo sapiens)
DKC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60832 DKC1
Gene Names
DKC1, NOLA4
Chain
initiator methionine:1, chain:2-514
Reference Genes
BioGPS Gene:1736 DKC1
COSMIC (genes):DKC1 DKC1
CTD Gene:1736 DKC1
dbSNP Gene:1736 DKC1
ENSEMBL:ENSG00000130826 DKC1
HGNC:2890 DKC1
KEGG Gene (Homo sapiens):1736 DKC1
Monarch:1736 DKC1
NCBI Gene:1736 DKC1
OMIM:300126 DKC1
UCSC:O60832 DKC1
Reference Transcript
RefSeq:NM_001363.4 DKC1
RefSeq:NM_001142463.2 DKC1
RefSeq:NM_001288747.1 DKC1
Other Identifiers
0000940452
11743467_at
11743468_at
11757159_at
17108500
17119802
1736
201478_s_at
201479_at
216212_s_at
34829_at
3996668
3996669
3996671
3996672
3996673
3996674
3996675
3996676
3996677
3996680
3996683
3996684
3996685
3996686
3996687
3996688
3996689
3996691
3996693
3996694
3996695
3996696
3996698
8170971
8170992
A_14_P126139
A_21_P0000338
A_23_P137143
A_32_P91906
GE54597
GO:0000455
GO:0000495
GO:0001522
GO:0001650
GO:0003674
GO:0003720
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005697
GO:0005730
GO:0005737
GO:0006259
GO:0006364
GO:0006396
GO:0007004
GO:0008150
GO:0009056
GO:0009058
GO:0009451
GO:0009982
GO:0015030
GO:0016779
GO:0016853
GO:0031118
GO:0031120
GO:0031429
GO:0032212
GO:0032991
GO:0033979
GO:0034513
GO:0034641
GO:0034655
GO:0042254
GO:0042592
GO:0043226
GO:0051276
GO:0051973
GO:0070034
GO:0072589
GO:0090661
GO:0090666
GO:0090669
GO:1904851
GO:1904871
GO:1904872
GO:1904874
GO:1990481
Hs.4747.1.S1_3p_a_at
ILMN_1671257
ILMN_3240280
PH_hs_0000480
TC0X000779.hg
g2737893_3p_a_at
g4503336_3p_at
Participant Of
hasComponent
Box H/ACA snoRNP [nucleoplasm]
DKC1:SHQ1 [nucleoplasm]
Telomerase RNP [nucleoplasm]
input
Biogenesis and assembly of the telomerase RNP
DKC1 binds SHQ1
Inferred To
dkc1 [nucleoplasm] (Danio rerio)
cbf5 [nucleoplasm] (Schizosaccharomyces pombe)
Nop60B [nucleoplasm] (Drosophila melanogaster)
Dkc1 [nucleoplasm] (Mus musculus)
Dkc1 [nucleoplasm] (Rattus norvegicus)
nola4 [nucleoplasm] (Dictyostelium discoideum)
DKC1 [nucleoplasm] (Bos taurus)
DKC1 [nucleoplasm] (Caenorhabditis elegans)
DKC1 [nucleoplasm] (Canis familiaris)
DKC1 [nucleoplasm] (Gallus gallus)
DKC1 [nucleoplasm] (Plasmodium falciparum)
DKC1 [nucleoplasm] (Sus scrofa)
DKC1 [nucleoplasm] (Xenopus tropicalis)
CBF5 [nucleoplasm] (Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001275676.1
,
NP_001354.1
,
NP_001135935.1
Target Pathogen
5b354852be737e166372eb41
OpenTargets
ENSG00000130826
GeneCards
O60832
HPA
ENSG00000130826-DKC1
Ensembl
ENST00000620277
,
ENSG00000130826
,
ENSP00000358563
,
ENSP00000478387
,
ENST00000369550
PRO
O60832
Orphanet
15869
HMDB Protein
HMDBP01675
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96HR8 NAF1
0.826
8
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.774
9
UniProt:Q9BUR4 WRAP53
2
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
WRAP53 [nucleoplasm]
(R-HSA-418386)
0.723
6
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.69
7
UniProt:O14746 TERT
1
TERT [nucleoplasm]
(R-HSA-163076)
0.669
3
UniProt:Q9NPE3 NOP10
1
NOP10 [nucleoplasm]
(R-HSA-6790665)
0.669
3
UniProt:Q6PI26 SHQ1
1
SHQ1 [nucleoplasm]
(R-HSA-9671152)
0.564
2
UniProt:Q9NY12 GAR1
1
GAR1 [nucleoplasm]
(R-HSA-6790707)
0.527
2
UniProt:Q6NT76 HMBX1
0.499
2
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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