Post-translational modification: synthesis of GPI-anchored proteins

Stable Identifier
R-HSA-163125
DOI
10.3180/REACT_1853.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Post-translational modification: synthesis of GPI-anchored proteins
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Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.

As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus.

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Event Information
Go Biological Process
C-terminal protein lipidation (0006501)
Orthologous Events
Post-translational modification: synthesis of GPI-anchored proteins (Bos taurus)
Post-translational modification: synthesis of GPI-anchored proteins (Caenorhabditis elegans)
Post-translational modification: synthesis of GPI-anchored proteins (Canis familiaris)
Post-translational modification: synthesis of GPI-anchored proteins (Danio rerio)
Post-translational modification: synthesis of GPI-anchored proteins (Dictyostelium discoideum)
Post-translational modification: synthesis of GPI-anchored proteins (Drosophila melanogaster)
Post-translational modification: synthesis of GPI-anchored proteins (Gallus gallus)
Post-translational modification: synthesis of GPI-anchored proteins (Mus musculus)
Post-translational modification: synthesis of GPI-anchored proteins (Plasmodium falciparum)
Post-translational modification: synthesis of GPI-anchored proteins (Rattus norvegicus)
Post-translational modification: synthesis of GPI-anchored proteins (Saccharomyces cerevisiae)
Post-translational modification: synthesis of GPI-anchored proteins (Schizosaccharomyces pombe)
Post-translational modification: synthesis of GPI-anchored proteins (Sus scrofa)
Post-translational modification: synthesis of GPI-anchored proteins (Xenopus tropicalis)
Created
D'Eustachio, P  (2005-04-18)
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