Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AMBRA1 [cytosol]
Stable Identifier
R-HSA-1632831
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Activating molecule in BECN1-regulated autophagy protein 1, AMRA1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
AMBRA1 binds DYNLL1,DYNLL2 (Homo sapiens)
AMBRA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9C0C7 AMBRA1
Gene Names
AMBRA1, DCAF3, KIAA1736
Chain
chain:1-1298
Reference Genes
BioGPS Gene:55626 AMBRA1
COSMIC (genes):AMBRA1 AMBRA1
CTD Gene:55626 AMBRA1
dbSNP Gene:55626 AMBRA1
ENSEMBL:ENSG00000110497 AMBRA1
ENSEMBL_homo_sapiens_GENE:ENSG00000110497.15 AMBRA1
HGNC:25990 AMBRA1
KEGG Gene (Homo sapiens):55626 AMBRA1
Monarch:55626 AMBRA1
NCBI Gene:55626 AMBRA1
OMIM:611359 AMBRA1
UCSC:Q9C0C7 AMBRA1
Reference Transcript
RefSeq:NM_001267783.1 AMBRA1
RefSeq:XM_005253009.3 AMBRA1
RefSeq:XM_005253014.3 AMBRA1
RefSeq:NM_017749.3 AMBRA1
RefSeq:XM_005253011.3 AMBRA1
RefSeq:XM_006718259.2 AMBRA1
RefSeq:NM_001267782.1 AMBRA1
RefSeq:NM_001300731.1 AMBRA1
Other Identifiers
11741563_a_at
11748994_a_at
11752494_a_at
16737717
219141_PM_s_at
219141_s_at
234237_PM_s_at
234237_s_at
3371555
3371556
3371557
3371558
3371559
3371560
3371561
3371562
3371563
3371564
3371565
3371566
3371567
3371572
3371573
3371578
3371583
3371584
3371585
3371596
3371597
3371608
3371611
3371612
3371617
3371618
3371619
3371620
3371621
3371622
3371623
3371624
3371627
3371628
3371629
3371630
3371631
3371635
3371636
52731_PM_at
52731_at
55626
67932_at
7947652
A_23_P353742
A_33_P3293169
GE55434
GO:0000045
GO:0000209
GO:0000278
GO:0000423
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005739
GO:0005741
GO:0005773
GO:0005776
GO:0005783
GO:0005829
GO:0005856
GO:0005925
GO:0005929
GO:0005930
GO:0006351
GO:0006355
GO:0006357
GO:0006914
GO:0007005
GO:0007049
GO:0007155
GO:0007399
GO:0008285
GO:0009267
GO:0010508
GO:0010667
GO:0012501
GO:0016567
GO:0019903
GO:0021915
GO:0023052
GO:0030154
GO:0030163
GO:0031410
GO:0031625
GO:0031667
GO:0035307
GO:0036211
GO:0043161
GO:0043226
GO:0043231
GO:0043524
GO:0045335
GO:0045591
GO:0048471
GO:0048856
GO:0051020
GO:0051897
GO:0060090
GO:0065003
GO:0070161
GO:0080008
GO:0098780
GO:1901526
GO:1904544
GO:1990756
GO:2000045
HMNXSV003024170
ILMN_1662681
PH_hs_0032437
TC11001720.hg
g8923272_3p_s_at
Participates
as an input of
AMBRA1 binds DYNLL1,DYNLL2 (Homo sapiens)
as a component of
AMBRA1:DYNLL1,DYNLL2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-AMBRA1 [cytosol]
Inferred To
Ambra1 [cytosol]
(Mus musculus)
Ambra1 [cytosol]
(Rattus norvegicus)
Ghost homologue of AMBRA1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of AMBRA1 [cytosol]
(Drosophila melanogaster)
Ghost homologue of AMBRA1 [cytosol]
(Gallus gallus)
Ghost homologue of AMBRA1 [cytosol]
(Schizosaccharomyces pombe)
ambra1 [cytosol]
(Xenopus tropicalis)
ambra1b [cytosol]
(Danio rerio)
AMBRA1 [cytosol]
(Bos taurus)
AMBRA1 [cytosol]
(Canis familiaris)
AMBRA1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_005253068.1
,
XP_005253066.1
,
NP_060219.2
,
NP_001287660.1
,
NP_001254711.1
,
XP_005253071.1
,
NP_001254712.1
,
XP_006718322.1
OpenTargets
ENSG00000110497
GeneCards
Q9C0C7
HPA
ENSG00000110497-AMBRA1
Ensembl
ENST00000458649
,
ENST00000683756
,
ENST00000314845
,
ENSP00000415327
,
ENSG00000110497
,
ENSP00000318313
,
ENST00000534300
,
ENSP00000508322
,
ENST00000528950
,
ENSP00000431926
,
ENSP00000433945
PRO
Q9C0C7
Pharos - Targets
Q9C0C7
PDB
8WQR
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.868
9
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.659
10
UniProt:O75385 ULK1
7
ULK1 [recycling endosome]
(R-HSA-8854761)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
0.641
3
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.638
3
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.638
3
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.591
3
UniProt:P12504 VIF
0.558
5
UniProt:Q9BW61 DDA1
1
DDA1 [nucleoplasm]
(R-HSA-8863297)
0.527
3
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.527
2
UniProt:P61962 DCAF7
2
DCAF7 [nucleoplasm]
(R-HSA-8863312)
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text